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Protein

Protein disulfide-isomerase A4

Gene

PDIA4

Organism
Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase A4UniRule annotation (EC:5.3.4.1UniRule annotation)
Alternative name(s):
Endoplasmic reticulum resident protein 72UniRule annotation
Gene namesi
Name:PDIA4Imported
OrganismiRhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana)Imported
Taxonomic identifieri61622 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeColobinaeRhinopithecus
Proteomesi
  • UP000233200 Componenti: Whole Genome Shotgun Assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24UniRule annotationAdd BLAST24
ChainiPRO_501420810225 – 643Protein disulfide-isomerase A4UniRule annotationAdd BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi204 ↔ 207Redox-activeUniRule annotation
Disulfide bondi553 ↔ 556Redox-activeUniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 154ThioredoxinInterPro annotationAdd BLAST135
Domaini156 – 299ThioredoxinInterPro annotationAdd BLAST144
Domaini503 – 634ThioredoxinInterPro annotationAdd BLAST132

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili31 – 60Sequence analysisAdd BLAST30

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Redox-active centerUniRule annotationSAAS annotation, RepeatSAAS annotation, SignalUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00930000150840
KOiK09582

Family and domain databases

InterProiView protein in InterPro
IPR005788 Disulphide_isomerase
IPR005792 Prot_disulphide_isomerase
IPR017068 Protein_diS-isomerase_A4
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 3 hits
PIRSFiPIRSF036862 Disulphide_isom_A4, 1 hit
SUPFAMiSSF52833 SSF52833, 5 hits
TIGRFAMsiTIGR01130 ER_PDI_fam, 1 hit
TIGR01126 pdi_dom, 3 hits
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 3 hits
PS51352 THIOREDOXIN_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A2K6RLF4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPRKAYLFL LLLGLAQLLA VAGAEGPDED SSNRENAIED EEEEEEDDEE
60 70 80 90 100
EDDLEVKEEN GVLVLNDANF DNFVADKDTV LLEFYAPWCG HCKQFAPEYE
110 120 130 140 150
KIANVLKDND PPIPVAKIDA TSASMLASRF DVSGYPTIKI LKKGQAVDYE
160 170 180 190 200
GSRTQEEIVA KVREVSQPDW TPPPEVTLVL TKENFDEVVN DADIILVEFY
210 220 230 240 250
APWCGHCKKL APEYEKAAKE LNKRSPPIPL AKVDATAETD LAKRFDVSGY
260 270 280 290 300
PTLKIFRKGR PFDYNGPREK YGIVDYMIEQ SGPPSKEILT LKQVQEFLKD
310 320 330 340 350
GDDVIIIGVF KGESDPAYQQ YQDAANNLRE DYKFHHAFST EIAKFLKVSQ
360 370 380 390 400
GQLVVMQPEK FQSKYEPRSH VMDVQGSTQD SAIKDFVLKY ALPLVGHRKA
410 420 430 440 450
SNEAKRYTRR PLVVVYYSVD FSFDYRAATQ FWRSKVLEVA KDFPEYTFAI
460 470 480 490 500
ADEEDYAGEV KDLGLSESGE DVNAAILDES GKKFAMEPEE FDSDTLREFV
510 520 530 540 550
TAFKKGKLKP VIKSQPVPKN NKGLVKVVVG KTFDSIVMDP KKDVLIEFYA
560 570 580 590 600
PWCGHCKQLE PVYSSLAKKY KGQKGLVIAK MDATANDVPS DRYKVEGFPT
610 620 630 640
IYFAPSGDKK NPVKFEGGDR DLEHLSKFIE EHATKLSRTK EEL
Length:643
Mass (Da):72,638
Last modified:March 28, 2018 - v1
Checksum:i0C9846F7826D124A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K6RLF9A0A2K6RLF9_RHIRO
Protein disulfide-isomerase A4
PDIA4
636Annotation score:
A0A2K6RLF5A0A2K6RLF5_RHIRO
Protein disulfide-isomerase A4
PDIA4
640Annotation score:

Sequence databases

RefSeqiXP_010367479.1, XM_010369177.1

Genome annotation databases

EnsembliENSRROT00000066356; ENSRROP00000041853; ENSRROG00000044093
GeneIDi104667011
KEGGirro:104667011

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_010367479.1, XM_010369177.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRROT00000066356; ENSRROP00000041853; ENSRROG00000044093
GeneIDi104667011
KEGGirro:104667011

Organism-specific databases

CTDi9601

Phylogenomic databases

GeneTreeiENSGT00930000150840
KOiK09582

Family and domain databases

InterProiView protein in InterPro
IPR005788 Disulphide_isomerase
IPR005792 Prot_disulphide_isomerase
IPR017068 Protein_diS-isomerase_A4
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 3 hits
PIRSFiPIRSF036862 Disulphide_isom_A4, 1 hit
SUPFAMiSSF52833 SSF52833, 5 hits
TIGRFAMsiTIGR01130 ER_PDI_fam, 1 hit
TIGR01126 pdi_dom, 3 hits
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 3 hits
PS51352 THIOREDOXIN_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2K6RLF4_RHIRO
AccessioniPrimary (citable) accession number: A0A2K6RLF4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: November 7, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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