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Entry version 10 (10 Apr 2019)
Sequence version 1 (28 Mar 2018)
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Protein
Submitted name:

Uncharacterized protein

Gene

CR2

Organism
Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CR2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri61622 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeColobinaeRhinopithecus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000233200 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Whole Genome Shotgun Assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1033 – 1058HelicalSequence analysisAdd BLAST26

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501437441321 – 1093Sequence analysisAdd BLAST1073

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi155 ↔ 198PROSITE-ProRule annotation
Disulfide bondi184 ↔ 211PROSITE-ProRule annotation
Disulfide bondi380 ↔ 407PROSITE-ProRule annotation
Disulfide bondi411 ↔ 454PROSITE-ProRule annotation
Disulfide bondi440 ↔ 467PROSITE-ProRule annotation
Disulfide bondi496 ↔ 523PROSITE-ProRule annotation
Disulfide bondi631 ↔ 658PROSITE-ProRule annotation
Disulfide bondi662 ↔ 705PROSITE-ProRule annotation
Disulfide bondi691 ↔ 718PROSITE-ProRule annotation
Disulfide bondi779 ↔ 822PROSITE-ProRule annotation
Disulfide bondi876 ↔ 903PROSITE-ProRule annotation
Disulfide bondi911 ↔ 954PROSITE-ProRule annotation
Disulfide bondi940 ↔ 967PROSITE-ProRule annotation
Disulfide bondi972 ↔ 1015PROSITE-ProRule annotation
Disulfide bondi1001 ↔ 1028PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 84SushiInterPro annotationAdd BLAST64
Domaini89 – 149SushiInterPro annotationAdd BLAST61
Domaini153 – 213SushiInterPro annotationAdd BLAST61
Domaini214 – 274SushiInterPro annotationAdd BLAST61
Domaini275 – 345SushiInterPro annotationAdd BLAST71
Domaini350 – 408SushiInterPro annotationAdd BLAST59
Domaini409 – 469SushiInterPro annotationAdd BLAST61
Domaini470 – 525SushiInterPro annotationAdd BLAST56
Domaini526 – 596SushiInterPro annotationAdd BLAST71
Domaini601 – 659SushiInterPro annotationAdd BLAST59
Domaini660 – 720SushiInterPro annotationAdd BLAST61
Domaini739 – 776SushiInterPro annotationAdd BLAST38
Domaini777 – 841SushiInterPro annotationAdd BLAST65
Domaini846 – 905SushiInterPro annotationAdd BLAST60
Domaini909 – 969SushiInterPro annotationAdd BLAST61
Domaini970 – 1030SushiInterPro annotationAdd BLAST61

Keywords - Domaini

SignalSequence analysis, SushiPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161110

KEGG Orthology (KO)

More...
KOi
K04012

Database of Orthologous Groups

More...
OrthoDBi
46968at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033 CCP, 14 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00084 Sushi, 14 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032 CCP, 15 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57535 SSF57535, 16 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50923 SUSHI, 16 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A2K6RIT0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAAGLLGVF LALVAPGVLG ISCGSPPPIL NGRISHHSTP IALGTVVRYT
60 70 80 90 100
CSTGFRLIGE KNTLCITKDQ VVGIWDKPAP KCEYFNKYST CPEPIVPGGY
110 120 130 140 150
KTRGSVPPYI HGDFVTFACK TNFSMNGNKS VWCQANSRWG PTRLPTCESV
160 170 180 190 200
FPLECPALPM IHNGHHTSEN VRSIAPGLSV TYSCESGYLL VGEKIINCLS
210 220 230 240 250
SGKWSAVPPT CEEARCKPLG RFPNGKVKEP PILQVGVTAN FFCDEGYQLQ
260 270 280 290 300
GPSSSRCVIA GQGVAWTKMP VCKEIFCPPP PPILNGRHTG NSLANVSYGS
310 320 330 340 350
IVTYTCDPDP EEGVNFILIG ENTLRCTVDS QKTGTWSGPA PRCELSTSAV
360 370 380 390 400
QCPHPQILRG RIVSAQKDRY TYNDTVIFAC MFGFTLKGSK QIRCNAQGTW
410 420 430 440 450
EPSAPVCEKE CQAPPNILNG QKEDRHMVRF APGTSIKYSC NPGYVLVGEE
460 470 480 490 500
SIQCTSEGIW TPPVPQCKVA VCEATEKQLL TKPQHQFIRP DVNSSCEEGY
510 520 530 540 550
KLSGSVYQEC QGTTPWFMEI RLCKEITCPP PPVIYNGAHT GSSLEDFPYG
560 570 580 590 600
TTVTYTCNSG PEGEVEFSLI GESTIRCTSN DQERGTWSGP APLCELSLLA
610 620 630 640 650
VQCSRVHVAN GYKISGKEAP YFYNDTVTFK CFNGFTLKGS SQIRCKANNT
660 670 680 690 700
WDPEIPVCEK GCQPPPGLHH GRHTGGNTVF FVSGMTVDYT CDPGYLLVGN
710 720 730 740 750
KSIHCMPSGN WSPSAPRCEE TCQPVREDLQ ELPVGSRVEL VNTSCQDGYR
760 770 780 790 800
LTGHTYHKCQ DAENGIWFKK IPLCKVIHCH PPPMIVNGKH TGMMAENFLY
810 820 830 840 850
GNEVSYECDQ GFYLLGEKKL QCRSDSKGRG SWSGPSPQCL QSPPVTRCPN
860 870 880 890 900
PEVKHGYKLN KTLSAYSHND IVYVDCHPGF IMNGSRVIRC HTDNTWVPGV
910 920 930 940 950
PTCIKKAFIA CQPPPKTPNG NHTGGNIARF SPGMSILYSC DQGYLLVGEA
960 970 980 990 1000
LLLCTHEGTW NRPAPHCKEV NCSSPADMDG IQKGLEPRKM YQYGAVVTLE
1010 1020 1030 1040 1050
CEDGYMLEGS SQSQCQADHQ WNPPLAVCRS RSLAPVLSGI AAGLILLIFL
1060 1070 1080 1090
IVVTLCMISK HRERNYYTNT SQKEAFRLEA REVYSIDPYN PAS
Length:1,093
Mass (Da):119,665
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8EAD3F09F7FF42A9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K6RIT4A0A2K6RIT4_RHIRO
Uncharacterized protein
CR2
1,034Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K6RIU8A0A2K6RIU8_RHIRO
Uncharacterized protein
CR2
972Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K6RIU4A0A2K6RIU4_RHIRO
Uncharacterized protein
CR2
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_010363934.1, XM_010365632.1
XP_010363935.1, XM_010365633.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRROT00000065426; ENSRROP00000040933; ENSRROG00000043679

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
104664178

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rro:104664178

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_010363934.1, XM_010365632.1
XP_010363935.1, XM_010365633.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRROT00000065426; ENSRROP00000040933; ENSRROG00000043679
GeneIDi104664178
KEGGirro:104664178

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1380

Phylogenomic databases

GeneTreeiENSGT00940000161110
KOiK04012
OrthoDBi46968at2759

Family and domain databases

CDDicd00033 CCP, 14 hits
InterProiView protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00084 Sushi, 14 hits
SMARTiView protein in SMART
SM00032 CCP, 15 hits
SUPFAMiSSF57535 SSF57535, 16 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 16 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K6RIT0_RHIRO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K6RIT0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: April 10, 2019
This is version 10 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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