Homeobox domain-containing protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cysteine-type endopeptidase activator activity involved in apoptotic process Source: Ensembl
• estrogen receptor activity Source: Ensembl
• estrogen receptor binding Source: Ensembl
• histone deacetylase binding Source: Ensembl
• MADS box domain binding Source: Ensembl
• nuclear receptor activity Source: Ensembl
• protein self-association Source: Ensembl
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl

GO - Biological processⁱ

• androgen receptor signaling pathway Source: Ensembl
• branching involved in prostate gland morphogenesis Source: Ensembl
• branching morphogenesis of an epithelial tube Source: Ensembl
• cellular response to drug Source: Ensembl
• cellular response to hypoxia Source: Ensembl
• cellular response to interleukin-1 Source: Ensembl
• cellular response to tumor necrosis factor Source: Ensembl
• dorsal aorta development Source: Ensembl
• epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
• heart development Source: Ensembl
• male gonad development Source: Ensembl
• metanephros development Source: Ensembl
• mitotic cell cycle arrest Source: Ensembl
• negative regulation of epithelial cell proliferation involved in prostate gland development Source: Ensembl
• negative regulation of estrogen receptor binding Source: Ensembl
• negative regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
• negative regulation of transcription, DNA-templated Source: Ensembl
• pharyngeal system development Source: Ensembl
• positive regulation of androgen secretion Source: Ensembl
• positive regulation of cell division Source: Ensembl
• positive regulation of cell population proliferation Source: Ensembl
• positive regulation of DNA-binding transcription factor activity Source: Ensembl
• positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
• positive regulation of mitotic cell cycle Source: Ensembl
• positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
• positive regulation of protein phosphorylation Source: Ensembl
• positive regulation of response to DNA damage stimulus Source: Ensembl
• positive regulation of transcription by RNA polymerase II Source: Ensembl
• protein kinase B signaling Source: Ensembl
• regulation of protein localization Source: Ensembl
• response to testosterone Source: Ensembl
• somitogenesis Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• estrogen receptor binding Source: Ensembl
• histone deacetylase binding Source: Ensembl
• MADS box domain binding Source: Ensembl
• protein self-association Source: Ensembl

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Coiled coil

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MLRATEPLPG EAKAEGAARP TPSKPLTSFL IQDILRDGAQ RRGGHTGSPR 
        60         70         80         90        100
RRDPEPEPEP EGGRGPAGVQ NDQLSPRPRA APEEAETLAE TEPERHLGSY 
       110        120        130        140        150
LLDCENTSGS LPSLPQTPKQ PQKRSRAAFS HTQVIELERK FSHQKYLSAP 
       160        170        180        190        200
ERAHLAKNLK LTETQVKIWF QNRRYKTKRK QLSSELGDLE KHSSLPALKE 
       210        220        230 
EAFSRASLVS LYNNYPYYPY LYCVGSWSPA FW                    

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ