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Entry version 16 (02 Jun 2021)
Sequence version 1 (28 Mar 2018)
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Protein
Submitted name:

APC regulator of WNT signaling pathway 2

Gene

APC2

Organism
Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processWnt signaling pathwayARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
APC regulator of WNT signaling pathway 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APC2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri61622 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeColobinaeRhinopithecus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000233200 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

MicrotubuleARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 57APC_N_CCInterPro annotationAdd BLAST52
Domaini1786 – 1969APC_basicInterPro annotationAdd BLAST184

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni94 – 120DisorderedSequence analysisAdd BLAST27
Regioni247 – 270DisorderedSequence analysisAdd BLAST24
Regioni741 – 765DisorderedSequence analysisAdd BLAST25
Regioni868 – 912DisorderedSequence analysisAdd BLAST45
Regioni955 – 992DisorderedSequence analysisAdd BLAST38
Regioni1010 – 1033DisorderedSequence analysisAdd BLAST24
Regioni1070 – 1152DisorderedSequence analysisAdd BLAST83
Regioni1173 – 1228DisorderedSequence analysisAdd BLAST56
Regioni1307 – 1337DisorderedSequence analysisAdd BLAST31
Regioni1381 – 1686DisorderedSequence analysisAdd BLAST306
Regioni1700 – 1977DisorderedSequence analysisAdd BLAST278

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili8 – 28Sequence analysisAdd BLAST21
Coiled coili131 – 151Sequence analysisAdd BLAST21
Coiled coili840 – 860Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1173 – 1207Polar residuesSequence analysisAdd BLAST35
Compositional biasi1208 – 1222Pro residuesSequence analysisAdd BLAST15
Compositional biasi1389 – 1412Polar residuesSequence analysisAdd BLAST24
Compositional biasi1533 – 1547Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1651 – 1684Basic and acidic residuesSequence analysisAdd BLAST34
Compositional biasi1700 – 1729Polar residuesSequence analysisAdd BLAST30
Compositional biasi1737 – 1756Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1867 – 1884Polar residuesSequence analysisAdd BLAST18
Compositional biasi1885 – 1908Pro residuesSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adenomatous polyposis coli (APC) family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysisARBA annotation, RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063749

Identification of Orthologs from Complete Genome Data

More...
OMAi
MCAIMKL

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026837, APC2
IPR009234, APC_basic_dom
IPR026831, APC_dom
IPR026818, Apc_fam
IPR032038, APC_N
IPR036149, APC_N_sf
IPR041257, APC_rep
IPR009223, APC_rpt
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR000225, Armadillo
IPR009224, SAMP

The PANTHER Classification System

More...
PANTHERi
PTHR12607, PTHR12607, 1 hit
PTHR12607:SF3, PTHR12607:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05956, APC_basic, 1 hit
PF16689, APC_N_CC, 1 hit
PF05923, APC_r, 3 hits
PF18797, APC_rep, 1 hit
PF00514, Arm, 1 hit
PF05924, SAMP, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00185, ARM, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit
SSF58050, SSF58050, 1 hit
SSF82931, SSF82931, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2K6PXN4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSVAPYEQ LVRQVEALKA ENSHLRQELR DNSSHLSKLE TETSGMKEVL
60 70 80 90 100
KHLQGKLEQE ARVLVSSGQT EVLEQLKALQ MDITSLYNLK FQPPALGPEP
110 120 130 140 150
ASRTPEGSPV HGSGPSKDSF GELSRATIRL LEELDRERCF LLNEIEKEEK
160 170 180 190 200
EKLWYYSQLQ GLSKRLDELP HVETQFSMQM DLIRQQLEFE AQHIRSLMEE
210 220 230 240 250
RFGTSDEMVQ RAQIRASRLE QIDKELLEAQ DRVQQTEPQA LLAVKSVPVD
260 270 280 290 300
EDPETEVPTH PEDGTPQPGN SKVEVVFWLL SMLATRDQED TARTLLAMSS
310 320 330 340 350
SPESCVAMRR SGCLPLLLQI LHGTEAAAGG RAGAPGAPGA KDARMRANAA
360 370 380 390 400
LHNIVFSQPD QGLARKEMRV LHVLEQIRAY CETCWDWLQA RDGAPEGGGA
410 420 430 440 450
SGAPVPIEPQ ICQATCAVMK LSFDEEYRRA MNELGGLQAV AELLQVDYEM
460 470 480 490 500
HKMTRDPLNL ALRRYAGMTL TNLTFGDVAN KATLCACRGC MEAIVAQLAS
510 520 530 540 550
DSEELHQVVS SILRNLSWRA DINSKKVLRE AGSVTALVQC VLRATKESTL
560 570 580 590 600
KSVLSALWNL SAHSTENKAA ICQVDGALGF LVSTLTYKCQ SNSLAIIESG
610 620 630 640 650
GGILRNVSSL IATREDYRQV LRDHNCLQTL LQHLTSHSLT IVSNACGTLW
660 670 680 690 700
NLSARSARDQ ELLWDLGAVG MLRNLVHSKH KMIAMGSAAA LRNLLAHRPA
710 720 730 740 750
KHQAAATAVS PGSCVPSLYV RKQRALEAEL DARHLAQALE HLEKHRPPAA
760 770 780 790 800
EATTKKPLPP LRHLDGLAQD YASDSGCFDD DDAPSSLAAA AATGEPASPA
810 820 830 840 850
ALSLFLGSPF LQGQALARTP PTRRGGKEAE KDASGEAAVA AKAKAKLALA
860 870 880 890 900
VARIDQLVED ISALHTSSDD SFSLSSGDPG QEVPREGRAQ SCSPCRGPDA
910 920 930 940 950
GRREAGSRAH PLLRLKAAHA SLSNDSLNSG SASDGYCPRE HMLPCPLAAL
960 970 980 990 1000
ASRREDPRCG QPRPSRLDLD LPGSQAEPPA REATSADARV RTIKLSPTYQ
1010 1020 1030 1040 1050
HVPLLEGASR VGAEPLAGPG TSPGARKQAW LPADHLSKVP EKLAAAPLSV
1060 1070 1080 1090 1100
ASKALQKLVA QEGPLSLSRC SSLSSLSSAG RPGPSEGGDL DDTDSSLEGL
1110 1120 1130 1140 1150
EEAGPGEAEL DSVWRAPGAT SLPVAIPAPR RNRGRGLGVE DATPSSSSEN
1160 1170 1180 1190 1200
YVQETPLVLS RCSSVSSLGS FESPSIASSI PSDPCSGQGS GTISPSELPD
1210 1220 1230 1240 1250
SPGQTMPPSR SKTPPLAPAP QGPPEASQFS LQWESYVKRF LDIADCRERC
1260 1270 1280 1290 1300
RLPSELDAGS VRFTVEKPDE NFSCASSLSA LALHEHYVQQ DVELRLLPSA
1310 1320 1330 1340 1350
CPERGGGAGG AGLHFAGHRR REEGPAPTGS RPRGAADQEL ELLRECLGTA
1360 1370 1380 1390 1400
VPARLRKVAS ALVPGRRALP VPVYMLVPAP APAQEDDSCT DSAEGTPVNF
1410 1420 1430 1440 1450
SSAASLSDET LQGPPRDQPG GPAGRQRPTG RPTSARQAVG HRHKAGGAGR
1460 1470 1480 1490 1500
SAEQARGTGK NRAGLELPLG RPPSAPADKD DSKPGRTRGD GALQSLCLTT
1510 1520 1530 1540 1550
PTEEAVYCFY GNDSDEEPPA AAPTPTHRRT SAIPRALTRE RLQGRKEVPA
1560 1570 1580 1590 1600
PSKATPSAPP PARAQPSLIA DETPPCYSLS SSASSLSEPE PPEPPSVSPR
1610 1620 1630 1640 1650
GREPAVTKDP GPGGGRDSSP SPRAAEELLQ RCISSALPRR RPPVSSLRRR
1660 1670 1680 1690 1700
KPRATRLDER PAEGSREHGE EAAGSDRASD LDSVEWRAIQ EGANSIVTWL
1710 1720 1730 1740 1750
HQAAAATREP SSESDSILSF VSGLSVGSTL QPPKHRKGRQ AGGEMGSARR
1760 1770 1780 1790 1800
PEKRGAASAK TSGSPRSPAG PEKPRGTQKT TPGVPAVLRG RTVIYVPSPA
1810 1820 1830 1840 1850
PRAQPKGTPG PRVTPRKVAP PCLAQSAAPA KVPSSGQQRS RSLHRPGKTS
1860 1870 1880 1890 1900
ELAALSQPPR SATPPARLAK TPSSSSSQTS PASQPLPRKR PPVTQAAGPL
1910 1920 1930 1940 1950
PGPGASPVPK TPARTLLAKQ HKTQRSPVRI PFMQKPARRG PPPLARAVPE
1960 1970 1980 1990 2000
PGPRGRAGTE AGPGARGGRX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
2010 2020 2030 2040 2050
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
2060 2070 2080 2090 2100
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
2110
XXXXXXXXXX XXXXXXXXX
Length:2,119
Mass (Da):226,100
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF8F75D646C2883C9
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRROT00000045481; ENSRROP00000021292; ENSRROG00000034571

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Genome annotation databases

EnsembliENSRROT00000045481; ENSRROP00000021292; ENSRROG00000034571

Phylogenomic databases

GeneTreeiENSGT00530000063749
OMAiMCAIMKL

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR026837, APC2
IPR009234, APC_basic_dom
IPR026831, APC_dom
IPR026818, Apc_fam
IPR032038, APC_N
IPR036149, APC_N_sf
IPR041257, APC_rep
IPR009223, APC_rpt
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR000225, Armadillo
IPR009224, SAMP
PANTHERiPTHR12607, PTHR12607, 1 hit
PTHR12607:SF3, PTHR12607:SF3, 1 hit
PfamiView protein in Pfam
PF05956, APC_basic, 1 hit
PF16689, APC_N_CC, 1 hit
PF05923, APC_r, 3 hits
PF18797, APC_rep, 1 hit
PF00514, Arm, 1 hit
PF05924, SAMP, 2 hits
SMARTiView protein in SMART
SM00185, ARM, 6 hits
SUPFAMiSSF48371, SSF48371, 1 hit
SSF58050, SSF58050, 1 hit
SSF82931, SSF82931, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K6PXN4_RHIRO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K6PXN4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: June 2, 2021
This is version 16 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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