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UniProtKB - A0A2K6PIP2 (A0A2K6PIP2_RHIRO)

Entry version 13 (10 Feb 2021)
Sequence version 1 (28 Mar 2018)
Previous versions | rss
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Protein
Submitted name:

Uncharacterized protein

Gene

TNRC6A

Organism
Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRNA-mediated gene silencingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNRC6AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri61622 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Colobinae › Rhinopithecus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000233200 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1065 – 1193Ago_hookInterPro annotationAdd BLAST129
Domaini1497 – 1770TNRC6-PABC_bdgInterPro annotationAdd BLAST274

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 144DisorderedSequence analysisAdd BLAST144
Regioni165 – 286DisorderedSequence analysisAdd BLAST122
Regioni427 – 446DisorderedSequence analysisAdd BLAST20
Regioni486 – 508DisorderedSequence analysisAdd BLAST23
Regioni550 – 691DisorderedSequence analysisAdd BLAST142
Regioni710 – 1133DisorderedSequence analysisAdd BLAST424
Regioni1150 – 1188DisorderedSequence analysisAdd BLAST39
Regioni1241 – 1264DisorderedSequence analysisAdd BLAST24
Regioni1315 – 1362DisorderedSequence analysisAdd BLAST48
Regioni1416 – 1448DisorderedSequence analysisAdd BLAST33
Regioni1569 – 1628DisorderedSequence analysisAdd BLAST60
Regioni1716 – 1742DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 54PolyampholyteSequence analysisAdd BLAST54
Compositional biasi58 – 110PolarSequence analysisAdd BLAST53
Compositional biasi111 – 125Pro-richSequence analysisAdd BLAST15
Compositional biasi165 – 222PolarSequence analysisAdd BLAST58
Compositional biasi246 – 286PolarSequence analysisAdd BLAST41
Compositional biasi550 – 668PolarSequence analysisAdd BLAST119
Compositional biasi669 – 691PolyampholyteSequence analysisAdd BLAST23
Compositional biasi710 – 729PolarSequence analysisAdd BLAST20
Compositional biasi741 – 774PolarSequence analysisAdd BLAST34
Compositional biasi793 – 810PolarSequence analysisAdd BLAST18
Compositional biasi824 – 942PolarSequence analysisAdd BLAST119
Compositional biasi974 – 996PolyampholyteSequence analysisAdd BLAST23
Compositional biasi1003 – 1049PolarSequence analysisAdd BLAST47
Compositional biasi1086 – 1111PolarSequence analysisAdd BLAST26
Compositional biasi1150 – 1164PolarSequence analysisAdd BLAST15
Compositional biasi1315 – 1357PolarSequence analysisAdd BLAST43
Compositional biasi1718 – 1732Pro-richSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GW182 family.ARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158180

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019486, Argonaute_hook_dom
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR032226, TNRC6_PABC-bd
IPR033501, TNRC6A

The PANTHER Classification System

More...PANTHERi		PTHR13020:SF28, PTHR13020:SF28, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10427, Ago_hook, 1 hit
PF16608, TNRC6-PABC_bdg, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928, SSF54928, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A2K6PIP2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRELEAKATK DVERNLSRDL VQEEEQLMEE KKKKKDDKKK KEAAQKKATE 
        60         70         80         90        100
QKIKVPEQIK PSVSQPQPAN SNNGTSTATS TNNNAKRATA NNQQPQQQPQ 
       110        120        130        140        150
QQQQPQQQPQ QQPQPQQPQA LPRYPREVPP RFRHQEHKQL LKRGQHFPVI 
       160        170        180        190        200
AANLGSAVKV LNSQSESSAL TNQQPQNNGE VQNSKNQSDI NHSTSGSHYE 
       210        220        230        240        250
NSQRGLVSST SDSSTNCKNA VVSDLSEKEA WPSVPGSDTE LASECMDADS 
       260        270        280        290        300
ASSSESERNI TIMASGNTGG EKDGLRNSTG LGSQNKFVVG SSSNNVGHGS 
       310        320        330        340        350
STGPWGFSHG AIISTCQVSV DAPESKSESS NNRMNAWGTV SSSSNGGLNP 
       360        370        380        390        400
STLNSASNHG AWPVLENNGL ALKGPVGSGS SGINIQCSTI GQMPNNQSIN 
       410        420        430        440        450
SKVSGGSTHG TWGSLQETCE SEVSGTQKVS FSGQPQNITT EMTGPNNTTN 
       460        470        480        490        500
FMTSSLPNSG SVQNNELPSS NTGAWRVSTM NHPQMQAPSG MNGTSLSHLS 
       510        520        530        540        550
NGESKSGGSY GTTWGAYGSN YSGDKCSGPN GQANGDTVNA TLMQPGVNGP 
       560        570        580        590        600
MGTNFQVNTN KGGGVWESGA ANSQSASWGS GNGANSGGSR RGWGTPAQNT 
       610        620        630        640        650
GTNLPSGEWN KLPSNQHSND SANGNGKKFT NGWKSTEEED QGSATSQTNE 
       660        670        680        690        700
QSSVWAKTGG TVESDGSTES TGRLEEKGTG ESQSRDRRKI DQHTLLQSIV 
       710        720        730        740        750
NRTDLDPRVL SNSGWGQTPI KQNTAWDTET SPRGERKTDN GTEAWGSSAT 
       760        770        780        790        800
QTFNSGACID KTSPNSNDTS SVSGWGDPKP ALRWGDSKGS NCQGGWEDDS 
       810        820        830        840        850
AATGMVKSNQ WGNCKEEKAA WNDSQKNKQG WGDGQKSSQG WSVSASDNWG 
       860        870        880        890        900
ETSRSNHWGE ANKKSSSGGS DSDRSVSGWN ELGKTSSFTW GNNINPNNSS 
       910        920        930        940        950
GWDESSKPTP SQGWGDPPKS NQSLGWGDSS KPVSSPDWNK QQDIVGSWGI 
       960        970        980        990       1000
PPATGKPPGT GWLGGPIPAP TKEEEPTGWE EPSPESIRRK MEIDDGTSAW 
      1010       1020       1030       1040       1050
GDPSKYNYKN VNMWNKNVPN GNSRSDQQAQ VHQLLTPASA ISNKEASSGS 
      1060       1070       1080       1090       1100
GWGEPWGEPS TPATTVDNGT SAWGKPIDSG PSWGEPIAAA SSTSTWGSSS 
      1110       1120       1130       1140       1150
VGPQALSKSG PKSMQDGWCG DDMPLPGNRP TGWEEEEDVE IGMWNSNSSQ 
      1160       1170       1180       1190       1200
ELNSSLNWPP YTKKMSSKGL SGKKRRRERG MMKGGNKQEE AWINPFVKQF 
      1210       1220       1230       1240       1250
SNISFSRDSP EENVQSNKMD LSGGMLQDKR MEIDKHSLNI GDYNRTVGKG 
      1260       1270       1280       1290       1300
PGSRPQISKE SSMERNPYFD KDGIVADESQ NMQFMSSQSM KLPPSNSALP 
      1310       1320       1330       1340       1350
NQALGSIAGL GMQNLNSVRQ NGNPSMFGVG NTAAQPRGMQ QPPAQPLSSS 
      1360       1370       1380       1390       1400
QPNLRAQVPP PLLSPQVPVS LLKYAPNNGG LNPLFGPQQV AMLNQLSQLN 
      1410       1420       1430       1440       1450
QLSQISQLQR LLAQQQRAQS QRSVPSGNRP QQDQQGRPLS VQQQMMQQSR 
      1460       1470       1480       1490       1500
QLDPNLLVKQ QTPPSQQQPL HQPAMKSFLD NVMPHTTPEL QKGPSPINAF 
      1510       1520       1530       1540       1550
SNFPIGLNSN LNVNMDMNSI KEPQSRLRKW TTVDSISVNT SLDQNSSKHG 
      1560       1570       1580       1590       1600
AISSGFRLEE SPFVPYDFMN SSTSPASPPG SIGDGWPRAK SPNGSSSVNW 
      1610       1620       1630       1640       1650
PPEFRPGEPW KGYPNIDPET DPYVTPGSVI NNLSVNTVRE VDHLRDRNSG 
      1660       1670       1680       1690       1700
SSSSLNTTLP STSAWSSIRA SNYNVPLSST AQSTSARNSD SKLTWSPGSV 
      1710       1720       1730       1740       1750
TNTSLAHELW KVPLPPKNIT APSRPPPGLT GQKPPLSTWD NSPLRVGGGW 
      1760       1770       1780       1790       1800
GNSDARYTPG SSWGESSSGR ITNWLVLKNL TPQIDGSTLR TLCMQHGPLI 
      1810       1820       1830       1840       1850
TFHLNLPHGN ALVRYSSKEE VVKAQKSLHM VSLWISAHCN LRLPGSKDSR 
      1860       1870       1880       1890       1900
PSAFQVAGIT GTYHRIWLSF AFLIEMGFHH VAQAGLKLLS SSNLPISASQ 
      1910       1920       1930       1940       1950
SAGITGVSHC AWPHRHLYIF KYPSLFCSPG CVSSSDEPQL LHSAMLSTLK 
      1960 
RLEDSLPWTS FP
Length:1,962
Mass (Da):210,850
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD887CA1B6C7ED26
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K6PIY7A0A2K6PIY7_RHIRO
Uncharacterized protein
TNRC6A
1,952Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K6PIQ3A0A2K6PIQ3_RHIRO
Uncharacterized protein
TNRC6A
1,954Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K6PIP7A0A2K6PIP7_RHIRO
Uncharacterized protein
TNRC6A
1,913Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRROT00000040564; ENSRROP00000016418; ENSRROG00000032360

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSRROT00000040564; ENSRROP00000016418; ENSRROG00000032360

Phylogenomic databases

GeneTreeiENSGT00940000158180

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR019486, Argonaute_hook_dom
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR032226, TNRC6_PABC-bd
IPR033501, TNRC6A
PANTHERiPTHR13020:SF28, PTHR13020:SF28, 1 hit
PfamiView protein in Pfam
PF10427, Ago_hook, 1 hit
PF16608, TNRC6-PABC_bdg, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K6PIP2_RHIRO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K6PIP2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: February 10, 2021
This is version 13 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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