ITGAV

Functionⁱ

GO - Molecular functionⁱ

C-X3-C chemokine binding Source: Ensembl
extracellular matrix binding Source: Ensembl
extracellular matrix protein binding Source: Ensembl
fibroblast growth factor binding Source: Ensembl
fibronectin binding Source: Ensembl
insulin-like growth factor I binding Source: Ensembl
integrin binding Source: Ensembl
neuregulin binding Source: Ensembl
opsonin binding Source: Ensembl
protease binding Source: Ensembl
protein kinase C binding Source: Ensembl
voltage-gated calcium channel activity Source: Ensembl

GO - Biological processⁱ

angiogenesis Source: Ensembl
apolipoprotein A-I-mediated signaling pathway Source: Ensembl
apoptotic cell clearance Source: Ensembl
cell adhesion mediated by integrin Source: Ensembl
cell-matrix adhesion Source: Ensembl
endodermal cell differentiation Source: Ensembl
ERK1 and ERK2 cascade Source: Ensembl
extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
heterotypic cell-cell adhesion Source: Ensembl
integrin-mediated signaling pathway Source: UniProtKB-KW
negative chemotaxis Source: Ensembl
negative regulation of entry of bacterium into host cell Source: Ensembl
negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
negative regulation of lipid storage Source: Ensembl
negative regulation of lipid transport Source: Ensembl
negative regulation of lipoprotein metabolic process Source: Ensembl
negative regulation of low-density lipoprotein receptor activity Source: Ensembl
negative regulation of macrophage derived foam cell differentiation Source: Ensembl
positive regulation of cell adhesion Source: Ensembl
positive regulation of cell migration Source: Ensembl
positive regulation of osteoblast proliferation Source: Ensembl
regulation of phagocytosis Source: Ensembl
regulation of transforming growth factor beta activation Source: Ensembl
substrate adhesion-dependent cell spreading Source: Ensembl
transforming growth factor beta production Source: Ensembl
viral entry into host cell Source: Ensembl

Keywordsⁱ

Molecular function	IntegrinUniRule annotationARBA annotation, ReceptorUniRule annotationARBA annotation
Biological process	Cell adhesionUniRule annotationARBA annotation
Ligand	CalciumARBA annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Integrin_alpha2 domain-containing proteinInterPro annotation
Gene namesⁱ	Name:ITGAVImported
Organismⁱ	Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana)Imported
Taxonomic identifierⁱ	61622 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Cercopithecoidea › Cercopithecidae › Colobinae › Rhinopithecus
Proteomesⁱ	UP000233200 Componentⁱ: Unplaced

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	994 – 1016	HelicalUniRule annotationAdd BLAST		23

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 30	UniRule annotationAdd BLAST		30
ChainⁱPRO_5014212084	31 – 1048	Integrin_alpha2 domain-containing proteinUniRule annotationAdd BLAST		1018

Keywords - PTMⁱ

GlycoproteinARBA annotation

Interactionⁱ

GO - Molecular functionⁱ

C-X3-C chemokine binding Source: Ensembl
extracellular matrix protein binding Source: Ensembl
fibroblast growth factor binding Source: Ensembl
fibronectin binding Source: Ensembl
insulin-like growth factor I binding Source: Ensembl
integrin binding Source: Ensembl
neuregulin binding Source: Ensembl
opsonin binding Source: Ensembl
protease binding Source: Ensembl
protein kinase C binding Source: Ensembl

Complete GO annotation on QuickGO ...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	32 – 98	FG-GAPPROSITE-ProRule annotationAdd BLAST	67
Repeatⁱ	109 – 170	FG-GAPPROSITE-ProRule annotationAdd BLAST	62
Repeatⁱ	173 – 225	FG-GAPPROSITE-ProRule annotationAdd BLAST	53
Repeatⁱ	237 – 291	FG-GAPPROSITE-ProRule annotationAdd BLAST	55
Repeatⁱ	292 – 357	FG-GAPPROSITE-ProRule annotationAdd BLAST	66
Repeatⁱ	358 – 415	FG-GAPPROSITE-ProRule annotationAdd BLAST	58
Repeatⁱ	419 – 482	FG-GAPPROSITE-ProRule annotationAdd BLAST	64
Domainⁱ	467 – 914	Integrin_alpha2InterPro annotationAdd BLAST	448

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1027 – 1048	DisorderedSequence analysisAdd BLAST		22

Sequence similaritiesⁱ

Belongs to the integrin alpha chain family.UniRule annotationARBA annotation

Keywords - Domainⁱ

RepeatARBA annotation, SignalUniRule annotationARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000158361
OMAⁱ	IANWQPK
Database of Orthologous Groups More...OrthoDBⁱ	743479at2759

Family and domain databases

Gene3Dⁱ	2.130.10.130, 1 hit
InterProⁱ	View protein in InterPro IPR013517, FG-GAP IPR013519, Int_alpha_beta-p IPR000413, Integrin_alpha IPR013649, Integrin_alpha-2 IPR018184, Integrin_alpha_C_CS IPR028994, Integrin_alpha_N IPR032695, Integrin_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01839, FG-GAP, 3 hits PF00357, Integrin_alpha, 1 hit PF08441, Integrin_alpha2, 1 hit
PRINTSⁱ	PR01185, INTEGRINA
SMARTⁱ	View protein in SMART SM00191, Int_alpha, 5 hits
SUPFAMⁱ	SSF69179, SSF69179, 3 hits
PROSITEⁱ	View protein in PROSITE PS51470, FG_GAP, 7 hits PS00242, INTEGRIN_ALPHA, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

A0A2K6NBD3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASPPRRRLR LGPRGLPLLL SGLLLPLCRA FNLDVDSPAE YSGPEGSYFG 
        60         70         80         90        100
FAVDFFVPSA SSRMFLLVGA PKANTTQPGI VEGGQVLKCD WSSTRRCQPI 
       110        120        130        140        150
EFDATGNRDY AKDDPLEFKS HQWFGASVRS KQDKILACAP LYHWRTELKQ 
       160        170        180        190        200
EREPVGTCFL QDGTKTVEYA PCRSQDIDAD GQGFCQGGFS IDFTKADRVL 
       210        220        230        240        250
LGGPGSFYWQ GQLISDQVAE IVSKYDPNVY SIKYNNQLAT RTAQAIFDDS 
       260        270        280        290        300
YLGYSVAVGD FNGDGIDDFV SGVPRAARTL GMVYIYDGKN MSSIYNFTGD 
       310        320        330        340        350
QMAAYFGFSV AATDINGDDY ADVFIGAPLF MDRGSDGKLQ EVGQVSVSLQ 
       360        370        380        390        400
RASGDFQTTK LNGFEVFARF GSAIAPLGDL DQDGFNDIAI AAPYGGEDKK 
       410        420        430        440        450
GIVYIFNGRS TGLNAVPSQI LEGQWAARSM PPSFGYSMKG ATDIDKNGYP 
       460        470        480        490        500
DLIVGAFGVD RAILYRARPV ITVNAGLEVY PSILNQDNKT CSLPGTALKV 
       510        520        530        540        550
SCFNVRFCLK ADGKGVLPRK LNFQVELLLD KLKQKGAIRR ALFFYSRSPS 
       560        570        580        590        600
HSKNMTISRG GLMQCEELIA YLRDESEFRD KLTPITIFME YWLDYRTAAD 
       610        620        630        640        650
TTGLQPILNQ FTPANISRQA HILLDCGEDN VCKPKLEVFV DSDQKKIYIG 
       660        670        680        690        700
DDNPLTLIVK AQNQGEGAYE AELIVSIPLQ ADFIGVVRNS EALARLSCAF 
       710        720        730        740        750
KTENQTRQVV CDLGNPMKAG TQLLAGLRFS VHQQSEMDTS VKFDLQIQSS 
       760        770        780        790        800
NLFDKVSPVV SHKVDLAVLA AVEIRGVSSP DHIFLPIPNW EHKENPETEE 
       810        820        830        840        850
DVGPVVQHIY ELRNNGPSSF NKAMLHLQWP YKYNNNTLLY ILHYDIDGPM 
       860        870        880        890        900
NCTSDMEINP LRIKISSLQT TEKNDTVAGQ GERDHLITKR DLALSEGDIH 
       910        920        930        940        950
TLGCGVAQCL KIVCQVGRLD RGKSAILYVK SLLWTETFMN KENQNHSYSL 
       960        970        980        990       1000
KSSASFNVIE FPYKNLPIED ITNSTLVTTN VTWGIQPAPM PVPVWVIILA 
      1010       1020       1030       1040 
VLAGLLLLAV LVFVMYRMGF FKRVRPPQEE QEREQLQPHE NGEGNSET

Length:1,048

Mass (Da):116,084

Last modified:March 28, 2018 - v1

Checksum:ⁱ22DCBBDE5E230771

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A2K6NBE6	A0A2K6NBE6_RHIRO	Integrin_alpha2 domain-containing p... Integrin_alpha2 domain-containing protein	ITGAV	1,012	Annotation score:
A0A2K6NBF2	A0A2K6NBF2_RHIRO	Integrin_alpha2 domain-containing p... Integrin_alpha2 domain-containing protein	ITGAV	1,002	Annotation score:
A0A2K6NBH0	A0A2K6NBH0_RHIRO	Integrin_alpha2 domain-containing p... Integrin_alpha2 domain-containing protein	ITGAV	1,023	Annotation score:

Sequence databases

NCBI Reference Sequences More...RefSeqⁱ	XP_010368605.1, XM_010370303.1

RefSeqⁱ

XP_010368605.1, XM_010370303.1

Genome annotation databases

Ensemblⁱ	ENSRROT00000007158; ENSRROP00000001590; ENSRROG00000005817
GeneIDⁱ	104667754
KEGGⁱ	rro:104667754

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A0A2K6NBD3	Integrin alpha-V	)	HUMAN		1048	UniRef90_P06756
Integrin alpha-V		BOVIN		1048
LOW QUALITY PROTEIN: integrin alpha-V		PTEVA		1052
Integrin subunit alpha V		MACMU		1051
Integrin subunit alpha V		RHIFE		1048
+252

Protein	Similar proteins		Species	Score	Length	Source
A0A2K6NBD3	Integrin alpha-V	)	HUMAN		1048	UniRef50_P06756
Integrin alpha-V		BOVIN		1048
Integrin alpha-V		CHICK		1034
LOW QUALITY PROTEIN: integrin alpha-V		PTEVA		1052
Integrin subunit alpha V		MACMU		1051
+505

Cross-referencesⁱ

Sequence databases

RefSeqⁱ	XP_010368605.1, XM_010370303.1

RefSeqⁱ

XP_010368605.1, XM_010370303.1

3D structure databases

ModBaseⁱ	Search...
SWISS-MODEL-Workspaceⁱ	Submit a new modelling project...

Genome annotation databases

Ensemblⁱ	ENSRROT00000007158; ENSRROP00000001590; ENSRROG00000005817
GeneIDⁱ	104667754
KEGGⁱ	rro:104667754

Organism-specific databases

CTDⁱ	3685

CTDⁱ

3685

Phylogenomic databases

GeneTreeⁱ	ENSGT00940000158361
OMAⁱ	IANWQPK
OrthoDBⁱ	743479at2759

Family and domain databases

Gene3Dⁱ	2.130.10.130, 1 hit
InterProⁱ	View protein in InterPro IPR013517, FG-GAP IPR013519, Int_alpha_beta-p IPR000413, Integrin_alpha IPR013649, Integrin_alpha-2 IPR018184, Integrin_alpha_C_CS IPR028994, Integrin_alpha_N IPR032695, Integrin_dom_sf
Pfamⁱ	View protein in Pfam PF01839, FG-GAP, 3 hits PF00357, Integrin_alpha, 1 hit PF08441, Integrin_alpha2, 1 hit
PRINTSⁱ	PR01185, INTEGRINA
SMARTⁱ	View protein in SMART SM00191, Int_alpha, 5 hits
SUPFAMⁱ	SSF69179, SSF69179, 3 hits
PROSITEⁱ	View protein in PROSITE PS51470, FG_GAP, 7 hits PS00242, INTEGRIN_ALPHA, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A2K6NBD3_RHIRO
Accessionⁱ	A0A2K6NBD3Primary (citable) accession number: A0A2K6NBD3
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 28, 2018
	Last sequence update:	March 28, 2018
	Last modified:	February 10, 2021
	This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A0A2K6NBD3 (A0A2K6NBD3_RHIRO)

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Integrin_alpha2 domain-containing protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ