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Protein

Inhibin alpha chain

Gene

INHA

Organism
Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionGrowth factorUniRule annotationSAAS annotation, HormoneUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibin alpha chainUniRule annotation
Gene namesi
Name:INHAImported
OrganismiRhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)Imported
Taxonomic identifieri61621 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeColobinaeRhinopithecus
Proteomesi
  • UP000233180 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_501444509119 – 367Inhibin alpha chainSequence analysisAdd BLAST349

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini230 – 367TGF_BETA_2InterPro annotationAdd BLAST138

Sequence similaritiesi

Belongs to the TGF-beta family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00390000005935
KOiK05500

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR017175 Inhibin_asu
IPR001839 TGF-b_C
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PTHR11848:SF117 PTHR11848:SF117, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PIRSFiPIRSF037328 Inhibin_alpha_subunit, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2K6LJS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLPLLLFLL LAPQGGHSCQ GPELARELVL AKVRALFLDA LGSPVVTREG
60 70 80 90 100
GDPGVRRLPR RHALGGFTRR GSEPEEEEED VSQAILFPAT GASCEDKPTA
110 120 130 140 150
GGLAQEAEEG LFTYMFRPSQ HTRSRQVTSA QLWFHTGLDR QGTAASNSSE
160 170 180 190 200
PLLGLLALSP AGPVAVPMSL GHAPPRWAVL HLATSAFSLL THPVLVLLLR
210 220 230 240 250
CPVCTCSAQP EATPFLVAHT RTRPPSGGER ARRSTPPMSW PWSPSALRLL
260 270 280 290 300
QRPPEEPAAH ANCHRVALNI SFQELGWERW IVYPPSFIFH YCHGGCGLHI
310 320 330 340 350
PPNLPLPVPG APPTPAQPPS LLPGAQPCCA ALPGTMRPLR VRTTSDGGYS
360
FKYETVPNLL TQHCACI
Length:367
Mass (Da):39,550
Last modified:March 28, 2018 - v1
Checksum:iDF90587E770D9F53
GO

Sequence databases

RefSeqiXP_017712272.1, XM_017856783.1

Genome annotation databases

EnsembliENSRBIT00000047664; ENSRBIP00000023767; ENSRBIG00000035797
GeneIDi108518433
KEGGirbb:108518433

Similar proteinsi

Entry informationi

Entry nameiA0A2K6LJS4_RHIBE
AccessioniPrimary (citable) accession number: A0A2K6LJS4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: July 18, 2018
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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