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Protein

Putative hydroxypyruvate isomerase

Gene

HYI

Organism
Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).UniRule annotation

Catalytic activityi

Hydroxypyruvate = 2-hydroxy-3-oxopropanoate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei150Proton donor/acceptorUniRule annotation1
Active sitei249Proton donor/acceptorUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionIsomeraseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Putative hydroxypyruvate isomeraseUniRule annotation (EC:5.3.1.22UniRule annotation)
Gene namesi
Name:HYIImported
OrganismiRhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)Imported
Taxonomic identifieri61621 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeColobinaeRhinopithecus
Proteomesi
  • UP000233180 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_501441459320 – 290Putative hydroxypyruvate isomeraseSequence analysisAdd BLAST271

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 220AP_endonuc_2InterPro annotationAdd BLAST197

Sequence similaritiesi

Belongs to the hyi family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00390000005462

Family and domain databases

InterProiView protein in InterPro
IPR026040 HyI-like
IPR036237 Xyl_isomerase-like_sf
IPR013022 Xyl_isomerase-like_TIM-brl
PfamiView protein in Pfam
PF01261 AP_endonuc_2, 1 hit
PIRSFiPIRSF006241 HyI, 1 hit
SUPFAMiSSF51658 SSF51658, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A2K6L7R6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAALRFSANL SWLFPELLGL PARLRAAGSS GFEAVEVAWP YAEPPEVLAR
60 70 80 90 100
AAREAGLRLV LINTPPGDQE KGEMGLGAVP GRQAAFRQGL EQAVRYAKAL
110 120 130 140 150
GCPRIHLMAG RVPQGADRRA VKAEMEIVFL ENLRHAAGVL AQEDLVGLLE
160 170 180 190 200
PINTRITDPQ YFLDTPQQAA AILQKVGRPN LQLQMDIFHW QIMDGNLTGN
210 220 230 240 250
IREFLPIVGH VQVAQVPGRG EPSSPGELNF PYLFQLLEDE GYKGFVGCEY
260 270 280 290
QPQGDTVEGL SWLRSYWDRR GHPEVASEGL HTTHMPLDSE
Length:290
Mass (Da):31,949
Last modified:March 28, 2018 - v1
Checksum:iF4747B8A15B52CC0
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K6L7T5A0A2K6L7T5_RHIBE
Putative hydroxypyruvate isomerase
HYI
300Annotation score:
A0A2K6L7U5A0A2K6L7U5_RHIBE
Putative hydroxypyruvate isomerase
HYI
296Annotation score:
A0A2K6L7W5A0A2K6L7W5_RHIBE
Uncharacterized protein
HYI
313Annotation score:

Sequence databases

RefSeqiXP_017737410.1, XM_017881921.1

Genome annotation databases

EnsembliENSRBIT00000043440; ENSRBIP00000019566; ENSRBIG00000033761
GeneIDi108535697

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_017737410.1, XM_017881921.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRBIT00000043440; ENSRBIP00000019566; ENSRBIG00000033761
GeneIDi108535697

Organism-specific databases

CTDi81888

Phylogenomic databases

GeneTreeiENSGT00390000005462

Family and domain databases

InterProiView protein in InterPro
IPR026040 HyI-like
IPR036237 Xyl_isomerase-like_sf
IPR013022 Xyl_isomerase-like_TIM-brl
PfamiView protein in Pfam
PF01261 AP_endonuc_2, 1 hit
PIRSFiPIRSF006241 HyI, 1 hit
SUPFAMiSSF51658 SSF51658, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2K6L7R6_RHIBE
AccessioniPrimary (citable) accession number: A0A2K6L7R6
Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: July 18, 2018
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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