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Entry version 14 (16 Oct 2019)
Sequence version 1 (28 Mar 2018)
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Protein

Histone-lysine N-methyltransferase

Gene
N/A
Organism
Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei3816S-adenosyl-L-methionineUniRule annotation1
Binding sitei3818S-adenosyl-L-methionineUniRule annotation1
Binding sitei3860S-adenosyl-L-methionineUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi3886ZincUniRule annotation1
Metal bindingi3934ZincUniRule annotation1
Binding sitei3935S-adenosyl-L-methionineUniRule annotation1
Metal bindingi3936ZincUniRule annotation1
Metal bindingi3941ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1136 – 1184CXXC-typePROSITE-ProRule annotationAdd BLAST49

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase
Biological processTranscription, Transcription regulationUniRule annotation
LigandMetal-binding, S-adenosyl-L-methionineUniRule annotationSAAS annotation, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseUniRule annotationSAAS annotation (EC:2.1.1.43UniRule annotationSAAS annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri61621 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeColobinaeRhinopithecus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000233180 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1136 – 1184CXXC-typeInterPro annotationAdd BLAST49
Domaini1420 – 1471PHD-typeInterPro annotationAdd BLAST52
Domaini1550 – 1614PHD-typeInterPro annotationAdd BLAST65
Domaini1690 – 1735BromoInterPro annotationAdd BLAST46
Domaini1847 – 1955PHD-typeInterPro annotationAdd BLAST109
Domaini1995 – 2051FYR N-terminalInterPro annotationAdd BLAST57
Domaini3643 – 3724FYR C-terminalInterPro annotationAdd BLAST82
Domaini3806 – 3922SETInterPro annotationAdd BLAST117
Domaini3930 – 3946Post-SETInterPro annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 97DisorderedSequence analysisAdd BLAST97
Regioni121 – 238DisorderedSequence analysisAdd BLAST118
Regioni291 – 342DisorderedSequence analysisAdd BLAST52
Regioni434 – 582DisorderedSequence analysisAdd BLAST149
Regioni702 – 937DisorderedSequence analysisAdd BLAST236
Regioni1026 – 1056DisorderedSequence analysisAdd BLAST31
Regioni1094 – 1154DisorderedSequence analysisAdd BLAST61
Regioni1189 – 1364DisorderedSequence analysisAdd BLAST176
Regioni1650 – 1700DisorderedSequence analysisAdd BLAST51
Regioni1783 – 1846DisorderedSequence analysisAdd BLAST64
Regioni2058 – 2110DisorderedSequence analysisAdd BLAST53
Regioni2122 – 2209DisorderedSequence analysisAdd BLAST88
Regioni2252 – 2310DisorderedSequence analysisAdd BLAST59
Regioni2350 – 2437DisorderedSequence analysisAdd BLAST88
Regioni2453 – 2595DisorderedSequence analysisAdd BLAST143
Regioni2624 – 2651DisorderedSequence analysisAdd BLAST28
Regioni2690 – 2760DisorderedSequence analysisAdd BLAST71
Regioni2961 – 3041DisorderedSequence analysisAdd BLAST81
Regioni3143 – 3222DisorderedSequence analysisAdd BLAST80
Regioni3441 – 3463DisorderedSequence analysisAdd BLAST23
Regioni3477 – 3620DisorderedSequence analysisAdd BLAST144
Regioni3762 – 3785DisorderedSequence analysisAdd BLAST24
Regioni3883 – 3884S-adenosyl-L-methionine bindingUniRule annotation2

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili362 – 382Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi70 – 92PolarSequence analysisAdd BLAST23
Compositional biasi173 – 192PolarSequence analysisAdd BLAST20
Compositional biasi193 – 215PolyampholyteSequence analysisAdd BLAST23
Compositional biasi314 – 340PolyampholyteSequence analysisAdd BLAST27
Compositional biasi434 – 484PolarSequence analysisAdd BLAST51
Compositional biasi524 – 545PolarSequence analysisAdd BLAST22
Compositional biasi546 – 565Pro-richSequence analysisAdd BLAST20
Compositional biasi702 – 720PolarSequence analysisAdd BLAST19
Compositional biasi736 – 834PolarSequence analysisAdd BLAST99
Compositional biasi835 – 887PolyampholyteSequence analysisAdd BLAST53
Compositional biasi1035 – 1050PolarSequence analysisAdd BLAST16
Compositional biasi1223 – 1237PolarSequence analysisAdd BLAST15
Compositional biasi1238 – 1261PolyampholyteSequence analysisAdd BLAST24
Compositional biasi1267 – 1290PolarSequence analysisAdd BLAST24
Compositional biasi1291 – 1306Pro-richSequence analysisAdd BLAST16
Compositional biasi1799 – 1824Pro-richSequence analysisAdd BLAST26
Compositional biasi2073 – 2095PolarSequence analysisAdd BLAST23
Compositional biasi2123 – 2151PolarSequence analysisAdd BLAST29
Compositional biasi2166 – 2209PolarSequence analysisAdd BLAST44
Compositional biasi2252 – 2297PolarSequence analysisAdd BLAST46
Compositional biasi2379 – 2395PolarSequence analysisAdd BLAST17
Compositional biasi2396 – 2422PolyampholyteSequence analysisAdd BLAST27
Compositional biasi2503 – 2537PolarSequence analysisAdd BLAST35
Compositional biasi2544 – 2571PolarSequence analysisAdd BLAST28
Compositional biasi2698 – 2723PolarSequence analysisAdd BLAST26
Compositional biasi2724 – 2760PolyampholyteSequence analysisAdd BLAST37
Compositional biasi2988 – 3041PolarSequence analysisAdd BLAST54
Compositional biasi3143 – 3160PolarSequence analysisAdd BLAST18
Compositional biasi3172 – 3199PolarSequence analysisAdd BLAST28
Compositional biasi3207 – 3222PolarSequence analysisAdd BLAST16
Compositional biasi3477 – 3507PolarSequence analysisAdd BLAST31
Compositional biasi3540 – 3583PolarSequence analysisAdd BLAST44
Compositional biasi3592 – 3606PolarSequence analysisAdd BLAST15

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1136 – 1184CXXC-typePROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

BromodomainPROSITE-ProRule annotation, Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160099

Identification of Orthologs from Complete Genome Data

More...
OMAi
KSGVMYF

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15693 ePHD_KMT2A, 1 hit
cd15588 PHD1_KMT2A, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001487 Bromodomain
IPR034732 EPHD
IPR003889 FYrich_C
IPR003888 FYrich_N
IPR037927 KMT2A
IPR041958 KMT2A_ePHD
IPR042023 KMT2A_PHD1
IPR016569 MeTrfase_trithorax
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR002857 Znf_CXXC
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR45838:SF2 PTHR45838:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05965 FYRC, 1 hit
PF05964 FYRN, 1 hit
PF00628 PHD, 1 hit
PF00856 SET, 1 hit
PF02008 zf-CXXC, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF010354 Methyltransferase_trithorax, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297 BROMO, 1 hit
SM00542 FYRC, 1 hit
SM00541 FYRN, 1 hit
SM00249 PHD, 3 hits
SM00508 PostSET, 1 hit
SM00317 SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50014 BROMODOMAIN_2, 1 hit
PS51805 EPHD, 1 hit
PS51543 FYRC, 1 hit
PS51542 FYRN, 1 hit
PS50868 POST_SET, 1 hit
PS50280 SET, 1 hit
PS51058 ZF_CXXC, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2K6KJ04-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHSCRWRFP PDPGTPGRRR RGRPGPRGAP RQRVPALLLP PGPRSRAAGA
60 70 80 90 100
PSPRVAAGSG AGVPGGAAAA SAASSSSASS SSSSSSSASS GPALLRVGPG
110 120 130 140 150
FDAALQVSAA IGTNLRRFRA VFGESGGGGG SGEDEQFLGF GSDEEVRVRS
160 170 180 190 200
PTRSPSVKTS PRKPRGRPRS GSDRNSAILS DPSVFSPLNK SETKSGDKIK
210 220 230 240 250
KKDSKSIEKK RGRPPTFPGV KIKITHGKDI SELPKGNKED NLKKIKRTPS
260 270 280 290 300
ATFQQATKIK KLRAGKLSPL KSKFKTGKLQ IGRKGVQIVR RRGRPPSTER
310 320 330 340 350
IKTPSGLLIN SELEKPQKVR KDKEGTPPLT KEDKTVVRQS PRRIKPVRII
360 370 380 390 400
PSSKRTDATI AKQLLQRAKK GAQKKIEKEA AQLQGRKVKT QVKNIRQFIM
410 420 430 440 450
PVVSAISSRI IKTPRRFIED EDYDPPIKIA RLESTPNSRF SAPSCGSSEK
460 470 480 490 500
SSAASQHSSQ MSSDSSRSSS PSVDTSTDSQ ASEEIQVLPE ERSDTPEVHT
510 520 530 540 550
PLPISQSPEN ESNDRRSRRY SVSERSFGSR TTKKLSTLQS APQQQTSSSP
560 570 580 590 600
PPPLLTPPPP LQPASSISDH TPWLMPPTIP LASPFLPAST APMQGKRKSI
610 620 630 640 650
LREPTFRWTS LKHSRSEPQY FSSAKYAKEG LIRKPIFDNF RPPPLTPEDV
660 670 680 690 700
GFASGFSASG TATSARLFSP LHSGTRFDMH KRSPLLRAPR FTPSEAHSRI
710 720 730 740 750
FESVTLPSNR TSAGTSSSGV SNRKRKRKVF SPIRSEPRSP SHSMRTRSGR
760 770 780 790 800
LSTSELSPLT PPSSVSSSLS ISVSPLATSA LNPTFTFPSH SLTQSGESAE
810 820 830 840 850
KNQRPRKQTS APPEPFSSSS PTPLFPWFTP GSQTERGRNK DKAPEELSKD
860 870 880 890 900
RDADKSVEKD KSRERDRERE KENKRESRKE KRKKGSEIQS SSALYPVGRV
910 920 930 940 950
SKEKVVGEDV ATSSSAKKAT GRKKSSSHDS GTDITSVTLG DTTAVKTKIL
960 970 980 990 1000
IKKGRGNLEK NNLDLGPTAP SLEKEKTLCL STPSSSTVKH STSSIGSMLA
1010 1020 1030 1040 1050
QADKLPMTDK RVASLLKKAK AQLCKIEKSK SLKQTDQPKA QGQESDSSET
1060 1070 1080 1090 1100
SVRGPRIKHV CRRAAVALGR KRAVFPDDMP TLSALPWEER EKILSSMGND
1110 1120 1130 1140 1150
DKSSIAGSED AEPLAPPIKP IKPVTRNKAP QEPPVKKGRR SRRCGQCPGC
1160 1170 1180 1190 1200
QVPEDCGVCT NCLDKPKFGG RNIKKQCCKM RKCQNLQWMP SKAYLQKQAK
1210 1220 1230 1240 1250
AVKKKEKKSK TSEKKESKES SVVKNVVDSS QKPTPSTRED PAPKKSSSEP
1260 1270 1280 1290 1300
PPRKPVEEKS EEGNVSAPGP ESKQATIPAS RKSSKQVSQP APVIPPQPPT
1310 1320 1330 1340 1350
TGPPRKEVPK TTPSEPKKKQ PPPPESGPEQ SKQKKVAPRP SIPVKQKPKE
1360 1370 1380 1390 1400
KEKPPPVNKQ ENAGTLNILS TLSNGNSSKQ KIPADGVHRI RVDFKEDCEA
1410 1420 1430 1440 1450
ENVWEMGGLG ILTSVPITPR VVCFLCASSG HVEFVYCQVC CEPFHKFCLE
1460 1470 1480 1490 1500
ENERPLEDQL ENWCCRRCKF CHVCGRQHQA TKVQNLLDLC VSGSCLCTLC
1510 1520 1530 1540 1550
EQTFSCHYFL NNTCVRCKSC GSTTPGKGWD AQWSHDFSLC HDCAKLFAKG
1560 1570 1580 1590 1600
NFCPLCDKCY DDDDYESKMM QCGKCDRWVH SKCENLSGTE DEMYEILSNL
1610 1620 1630 1640 1650
PESVAYTCVN CTERHPAEWR LALEKELQIS LKQVLTALLN SRTTSHLLRY
1660 1670 1680 1690 1700
RQAAKPPDLN PETEESIPSR SSPEGPDPPV LTEVSKQDDQ QPLDLEGVKR
1710 1720 1730 1740 1750
KMDQGNYTSV LEFSDDIVKI IQAAINSDGG QPEIKKANSM VKSFFIRCQK
1760 1770 1780 1790 1800
SRFWEPNKVS SNSGMLPNAV LPPSLDHNYA QWQEREENSH TEQPPLMKKI
1810 1820 1830 1840 1850
IPAPKPKGPG EPDSPTPLHP PTPPILSTDR SREDSPELNP PPGIEDNRQC
1860 1870 1880 1890 1900
ALCLTYGDDS ANDAGRLLYI GQNEWTHVNC ALWSAEVFED DDGSLKNVHM
1910 1920 1930 1940 1950
AVIRGKQLRC EFCQKPGATV GCCLTSCTSN YHFMCSRAKN CVFLDDKKVY
1960 1970 1980 1990 2000
CQRHRDLIKG EVVPENGFEV FRRVFVDFEG ISLRRKFLNG LEPENIHMMI
2010 2020 2030 2040 2050
GSMTIDCLGI LNDLSDCEDK LFPIGYQCSR VYWSTTDARK RCVYTCKIVE
2060 2070 2080 2090 2100
CRPPVVEPDI NSTVEHDENR TIAHSPTSFT ESSSKENQNT TEIISPPSPD
2110 2120 2130 2140 2150
RPPHSQTSGS CYYHVISKVP RIRTPSYSPT QRSPGCRPLP SAGSPTPTTH
2160 2170 2180 2190 2200
EIVTVGDPLL SSGLRSIGSR RHSTSSLSPQ RSKLRIMSPM RTGNTYSRNN
2210 2220 2230 2240 2250
VSSGSTIGTA TDLESSAKAV DHVLGPLNSS TSLGQNTSTS SNLQRTVVTV
2260 2270 2280 2290 2300
GNKNSHLDGS SSSEMKQSSA SDLASKSSSL KGEKTKVLSS KSSEGSAHNV
2310 2320 2330 2340 2350
AYPGIPKLAP QVHNTTSREL NVSKIGSFAE PSSVSFSSKE ALSFPHLHLR
2360 2370 2380 2390 2400
GQRNDRDQHT DSTQSANPSP DEDTEVKTLK LSGMSNRSSI INEHMGSSSR
2410 2420 2430 2440 2450
DRRQKGKKSC KETFKEKHSS KSFLEPGQVT TGEEGNLKPE FMDEVLTSEY
2460 2470 2480 2490 2500
MGQRPCNNVS SDKIGDKGLS MPGVPKAPPM QVEGSAKELQ APRKRTVKVT
2510 2520 2530 2540 2550
LTPLKMENES QSKNTLKESS PASPLQIEST SPPEPISASE NPADGPVAQP
2560 2570 2580 2590 2600
SPNNTSCQDS QSNNYQTLPV QDRNLMLPDG PKPQEDGSFK RRYPRRSARA
2610 2620 2630 2640 2650
RSNMFFGLTP LYGVRSYGEE DIPFYSSSTG KKRGKRSAEG QVDGADDLST
2660 2670 2680 2690 2700
SDEDDLYYYN FTRTVISSGG EERLASHNLF REEEQCDLPK ISQLDGVDDG
2710 2720 2730 2740 2750
TESDTSVTAT TRKSSQIPKR NGKENGTENL KIDRPEDAGE KEHVIKSSVG
2760 2770 2780 2790 2800
HKNEPKMDNC HSVSRVKTQG QDSLEAQLSS LESSRRVHTS TPSDKNLLDT
2810 2820 2830 2840 2850
YNTELLKSDS DNNNSDDCGN ILPSDIMDFV LKNTPSMQAL GESPESSSSE
2860 2870 2880 2890 2900
LLNLGEGLGL DSNREKDMGL FEVFSQQLPT TEPVDSSVSS SISAEEQFEL
2910 2920 2930 2940 2950
PLELPSDLSV LTTRSPTVPS QNPSRLAVIS DSGEKRVTIT EKSVASSEGD
2960 2970 2980 2990 3000
PALLSPGVDP APEGHMTPDH FIQGHMDADH ISSPPCGSVE QGHGNNQDLT
3010 3020 3030 3040 3050
RNSSTPGLQV PVSPTVPIQN QKYVPNSTDS PGPSQISNAA VQTTPPHLKP
3060 3070 3080 3090 3100
ATEKLIVVNQ NMQPLYVLQT LPNGVTQKIQ LTSSVSSTPS VMETNTSVLG
3110 3120 3130 3140 3150
PMGSGLTLTT GLNPSLPTSQ SLFPSASKGL LPMSHHQHLH SFPAATQSSF
3160 3170 3180 3190 3200
PPNISSPPSG LLIGVQPPPD PQLLVSESSQ RTDLSTTVAT PSSGLKKRPI
3210 3220 3230 3240 3250
SRLQTRKNKK LAPSSTPSNI APSDVVSNMT LINFTPSQLP NHPNLLDLGS
3260 3270 3280 3290 3300
LNTSSHRTVP NIIKRSKSSI MYFEPAPLLP QSVGGTAATA SGTSTISQDT
3310 3320 3330 3340 3350
SHLTSGSVSG LASSSSVLNV VSMQTTTTPT SSASVPGHVT LTNPRLLGTP
3360 3370 3380 3390 3400
DIGSISNLLI KASQQSLGIQ DQPVALPPSS GMFPQLGTSQ TPSTAAMTAA
3410 3420 3430 3440 3450
SSICVLPSTQ TTGITAASPS GEADEHYQLQ HVNQLLASKT GIHSSQRDLD
3460 3470 3480 3490 3500
SASGPQVSNF TQTVDAPNSV GLEQNKALSS AVQASSTSPG GSPSSPSSGQ
3510 3520 3530 3540 3550
RSASPSVPGP TKPKPKTKRF QLPLDKGNGK KHKVSHLRTS SSEAHIPDQE
3560 3570 3580 3590 3600
ATSLTSGTGT PGAEAEQQDT ANVEQSSQKE CGQPAGQVAA LPEVQVTQNP
3610 3620 3630 3640 3650
ANEQESTEPK TVEEEESNFS SPLMLWLQQE QKRKENITEK KPKKGLVFEI
3660 3670 3680 3690 3700
SSDDGFQICA ESIEDAWKSL TDKVQEARSN ARLKQLSFAG VNGLRMLGIL
3710 3720 3730 3740 3750
HDAVVFLIEQ LSGAKHCRNY KFRFHKPEEA NEPPLNPHGS ARAEVHLRKS
3760 3770 3780 3790 3800
AFDMFNFLAS KHRQPPEYNP NDEEEEEVQL KSARRATSMD LPMPMRFRHL
3810 3820 3830 3840 3850
KKTSKEAVGV YRSPIHGRGL FCKRNIDAGE MVIEYAGNVI RSIQTDKREK
3860 3870 3880 3890 3900
YYDSKGIGCY MFRIDDSEVV DATMHGNAAR FINHSCEPNC YSRVINIDGQ
3910 3920 3930 3940
KHIVIFAMRK IYRGEELTYD YKFPIEDASN KLPCNCGAKK CRKFLN
Length:3,946
Mass (Da):429,932
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i50306A15109D3F7E
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSRBIT00000034892; ENSRBIP00000011239; ENSRBIG00000029481

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSRBIT00000034892; ENSRBIP00000011239; ENSRBIG00000029481

Phylogenomic databases

GeneTreeiENSGT00940000160099
OMAiKSGVMYF

Family and domain databases

CDDicd15693 ePHD_KMT2A, 1 hit
cd15588 PHD1_KMT2A, 1 hit
Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR034732 EPHD
IPR003889 FYrich_C
IPR003888 FYrich_N
IPR037927 KMT2A
IPR041958 KMT2A_ePHD
IPR042023 KMT2A_PHD1
IPR016569 MeTrfase_trithorax
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR002857 Znf_CXXC
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR45838:SF2 PTHR45838:SF2, 1 hit
PfamiView protein in Pfam
PF05965 FYRC, 1 hit
PF05964 FYRN, 1 hit
PF00628 PHD, 1 hit
PF00856 SET, 1 hit
PF02008 zf-CXXC, 1 hit
PIRSFiPIRSF010354 Methyltransferase_trithorax, 1 hit
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SM00542 FYRC, 1 hit
SM00541 FYRN, 1 hit
SM00249 PHD, 3 hits
SM00508 PostSET, 1 hit
SM00317 SET, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50014 BROMODOMAIN_2, 1 hit
PS51805 EPHD, 1 hit
PS51543 FYRC, 1 hit
PS51542 FYRN, 1 hit
PS50868 POST_SET, 1 hit
PS50280 SET, 1 hit
PS51058 ZF_CXXC, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K6KJ04_RHIBE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K6KJ04
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: October 16, 2019
This is version 14 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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