Early growth response protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
• double-stranded methylated DNA binding Source: Ensembl
• hemi-methylated DNA-binding Source: Ensembl
• histone acetyltransferase binding Source: Ensembl
• promoter-specific chromatin binding Source: Ensembl
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: Ensembl
• zinc ion binding Source: Ensembl

GO - Biological processⁱ

• BMP signaling pathway Source: Ensembl
• cellular response to gamma radiation Source: Ensembl
• cellular response to interleukin-8 Source: Ensembl
• circadian regulation of gene expression Source: Ensembl
• circadian temperature homeostasis Source: Ensembl
• estrous cycle Source: Ensembl
• interleukin-1-mediated signaling pathway Source: Ensembl
• locomotor rhythm Source: Ensembl
• negative regulation of canonical Wnt signaling pathway Source: Ensembl
• negative regulation of transcription by RNA polymerase II Source: Ensembl
• positive regulation of chemokine production Source: Ensembl
• positive regulation of hormone biosynthetic process Source: Ensembl
• positive regulation of interleukin-1 beta production Source: Ensembl
• positive regulation of pri-miRNA transcription by RNA polymerase II Source: Ensembl
• regulation of apoptotic process Source: Ensembl
• regulation of progesterone biosynthetic process Source: Ensembl
• regulation of protein sumoylation Source: Ensembl
• regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: Ensembl
• response to glucose Source: Ensembl
• response to insulin Source: Ensembl
• response to ischemia Source: Ensembl
• skeletal muscle cell differentiation Source: Ensembl
• T cell differentiation Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• histone acetyltransferase binding Source: Ensembl

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MAAAKAEMQL MSPLQISDPF GSFPHSPTMD NYPKLEEMML LSNGAPQFLG 
        60         70         80         90        100
AAGAPEGSGS NSSSSSGGGG GGGGGSSSSS SSTFNPQADT GEQPYEHLTA 
       110        120        130        140        150
ESFPDISLNN EKVLVETSYP SQTTRLPPIT YTGRFSLEPA PNSGNTLWPE 
       160        170        180        190        200
PLFSLVSGLV SMTNPPASSS SAPSPAASSS SASQSPPLSC AVPSNDSSPI 
       210        220        230        240        250
YSAAPTFPTP NTDIFPEPQS QAFPGSAGTA LQYPPPAYPA AKGGFQVPMI 
       260        270        280        290        300
PDYLFPQQQG DLGLGTPDQK PFQGLESRTQ QPSLTPLSTI KAFATQSGSQ 
       310        320        330        340        350
DLKALNTSYQ SQLIKPSRMR KYPNRPSKTP PHERPYACPV ESCDRRFSRS 
       360        370        380        390        400
DELTRHIRIH TGQKPFQCRI CMRNFSRSDH LTTHIRTHTG EKPFACDICG 
       410        420        430        440        450
RKFARSDERK RHTKIHLRQK DKKADKSVVA SSATSSLSSY PSPVATSYPS 
       460        470        480        490        500
PVTTSYPSPA TTSYPSPVPT SFSSPGSSTY PSPVHSGFPS PSVATTYSSV 
       510        520        530        540 
PPAFPAQVSS FPSSAVTNSF SASTGLSDMT ATFSPRTIEI C          

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ