Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 10 (05 Jun 2019)
Sequence version 1 (28 Mar 2018)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein
Submitted name:

Uncharacterized protein

Gene

PPL

Organism
Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPLImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPropithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri379532 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesStrepsirrhiniLemuriformesIndriidaePropithecus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000233160 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Whole Genome Shotgun Assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini399 – 455SH3InterPro annotationAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 22DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili24 – 51Sequence analysisAdd BLAST28
Coiled coili256 – 283Sequence analysisAdd BLAST28
Coiled coili357 – 384Sequence analysisAdd BLAST28
Coiled coili590 – 624Sequence analysisAdd BLAST35
Coiled coili697 – 717Sequence analysisAdd BLAST21
Coiled coili760 – 780Sequence analysisAdd BLAST21
Coiled coili791 – 818Sequence analysisAdd BLAST28
Coiled coili892 – 926Sequence analysisAdd BLAST35
Coiled coili950 – 991Sequence analysisAdd BLAST42
Coiled coili1003 – 1051Sequence analysisAdd BLAST49
Coiled coili1070 – 1111Sequence analysisAdd BLAST42
Coiled coili1130 – 1164Sequence analysisAdd BLAST35
Coiled coili1188 – 1222Sequence analysisAdd BLAST35
Coiled coili1248 – 1282Sequence analysisAdd BLAST35
Coiled coili1308 – 1356Sequence analysisAdd BLAST49
Coiled coili1375 – 1447Sequence analysisAdd BLAST73
Coiled coili1466 – 1493Sequence analysisAdd BLAST28
Coiled coili1509 – 1592Sequence analysisAdd BLAST84
Coiled coili1619 – 1639Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153578

Database of Orthologous Groups

More...
OrthoDBi
35436at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041615 Desmoplakin_SH3
IPR035915 Plakin_repeat_sf
IPR001101 Plectin_repeat
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17902 SH3_10, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00250 PLEC, 2 hits
SM00150 SPEC, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF75399 SSF75399, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2K6GRT1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSLFKKRNK GKYSPSVQTR SISNKELSEL IEQLQKNADQ VEKNIVDTEA
60 70 80 90 100
KMQSDLARLQ EGRQPEHRDV ALQKVSDSEK LLYVLEADAA IAKHMKHPQG
110 120 130 140 150
DMIAEDIRQL KERVTNLRGK HKQIYNLAVK EVDPQVNWAA LVEEKLDKLS
160 170 180 190 200
SQSFGTDLPL VDHQVEQHNI FHNEVKAIGP HLAKDGDKEQ NSELRAQYQK
210 220 230 240 250
LLAASQARQQ HLSSLQDYMQ RCTNELYWLD QQAKGRMQYD WSDHNLDYPS
260 270 280 290 300
RRRQYENFIN RNLEAKEERI NKLHSEGDQL LAAEHPGRNS IEAHMEAVHA
310 320 330 340 350
DWKEYLNLLI CEESHLKYME DYHQFHRDVK DAQELLHKVD SDLDQKYSPD
360 370 380 390 400
FKDQYQIELL LRELDDQEKA LDKYEDVVRG LQKRGQQVVP LKYRRETPLK
410 420 430 440 450
PIPVEALCDF ESDQGLISRG YSYTLQKNNG ESWELVDSAG NKLTAPAVCF
460 470 480 490 500
MIPPTDPEAL ALADSLGSQY LSVRQKAAGS KRALQQRHEV LKTENPGDAS
510 520 530 540 550
DLQGRQLLAG LDKVASDLDR QEKAITGILR PPLEQGRAVQ DSAERAKDLK
560 570 580 590 600
NITNELLRIK PEKTRSTAEC EAFVQALPGS GTVPLLRTRV EDTNRKYERL
610 620 630 640 650
VQLLDSAQEK VDMANRLEKS LQQAWELLAT HENQLGQDDT VPESGRALDS
660 670 680 690 700
KRQELAAMAS ELQAKKSLLG EVERNLQAAK QCSSMLASRF QEHCPDLERQ
710 720 730 740 750
EAEVHKLGQR FDNLRQQVER RAQSLHSAGA AYADYCSGRD HVLQFLSNIP
760 770 780 790 800
TYEPQETDSL SQVETKVKNQ KNLLDEIAGR EQEVQKVYTS SQRYQQAVKD
810 820 830 840 850
YELEAEKLRT LLDLENGRNS HMNKRARLQS PAAKVKEEEA ALATKFTEVN
860 870 880 890 900
AINRQRLQNL EFALNLLRQQ PEAEVAHETL QGSEPGRRVE EAWKIRKELE
910 920 930 940 950
EETERRQQLE NEVRSAQEEI RTLRNQRPQE SVVRKEVLKK VPDPALEESF
960 970 980 990 1000
QQLQRTLAEE QHKNQLLQEE LEALQLRLRT LEQETRDGGQ EYVVKEVLRI
1010 1020 1030 1040 1050
EPDRAQADEV QHLREELEVL RRQKGAREAE VLLLQQRVAT LAEEKSRAQE
1060 1070 1080 1090 1100
KVTEREVVKL QNDPQLEAEY RQLQEDHQRE GKLREKQEEE LSFLQDKLKR
1110 1120 1130 1140 1150
LEKERAMAEG KITVKEVLKV EKDVAAEREV SDLTRQYEDE AAKARASQRE
1160 1170 1180 1190 1200
KTELLRKIWA LEEENAKVVV QEKVREIVRP DPKAESEVAN LRLELVEQER
1210 1220 1230 1240 1250
KYRGAEEQLK SYQSELEDLK RRGPQVEVKE VTKEVIKYRT DPEMEKELQR
1260 1270 1280 1290 1300
LREEIVDKTR LIERCDLEIY QLKQEIQSLK DTKPQVQTKE VIQEILQFQE
1310 1320 1330 1340 1350
DPQTKEEVES LRAKLTEEQK KQVDLERERA SQEERIARKE EELSQVKERV
1360 1370 1380 1390 1400
VQQEVVRYEE EPGLRAEVTA FGESIDVELR QIDKLRAELR RLQRRRAELE
1410 1420 1430 1440 1450
RQLEDLERER QGRREAEREV QRLQQRLAEL EQEETAAREK VTRKQKVVLQ
1460 1470 1480 1490 1500
QDPQQAREHT LLRLQLEEEQ HRRQLLEGEL ETLRQKLAAL EKAEVKEKVV
1510 1520 1530 1540 1550
FSESVQVDKG DTEQEIQKLK HSLEEESRSK RELDAEVNRL EAKLSELEFH
1560 1570 1580 1590 1600
NSKSSKELDF LREENHKLQL ERQNLQLETR RLQSEIEIAA TETRDLRNVA
1610 1620 1630 1640 1650
TADSGTNLDS RLWSLERELD DLKKLSKDKD LEIDELQKRL GSVAVKREQR
1660 1670 1680 1690 1700
ENHLRRSIVV IDPDTGRELS PEEAHRAGLI DWNMFVKLRS QECDWEEISV
1710 1720 1730 1740 1750
KGPNGESSVI HDRKSGKKFS IEEALQSGRL TPAQYDRYVN KDMSIQELAV

LVSGQK
Length:1,756
Mass (Da):204,395
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC6466C874B552B61
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_012503264.1, XM_012647810.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSPCOT00000039875; ENSPCOP00000028940; ENSPCOG00000027149

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
105813171

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_012503264.1, XM_012647810.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPCOT00000039875; ENSPCOP00000028940; ENSPCOG00000027149
GeneIDi105813171

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5493

Phylogenomic databases

GeneTreeiENSGT00940000153578
OrthoDBi35436at2759

Family and domain databases

InterProiView protein in InterPro
IPR041615 Desmoplakin_SH3
IPR035915 Plakin_repeat_sf
IPR001101 Plectin_repeat
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
PfamiView protein in Pfam
PF17902 SH3_10, 1 hit
SMARTiView protein in SMART
SM00250 PLEC, 2 hits
SM00150 SPEC, 3 hits
SUPFAMiSSF75399 SSF75399, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K6GRT1_PROCO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K6GRT1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: June 5, 2019
This is version 10 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again