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Protein
Submitted name:

Uncharacterized protein

Gene

LAMB2

Organism
Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:LAMB2Imported
OrganismiPropithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli)Imported
Taxonomic identifieri379532 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesStrepsirrhiniLemuriformesIndriidaePropithecus
Proteomesi
  • UP000233160 Componenti: Whole Genome Shotgun Assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_501445513328 – 1793Sequence analysisAdd BLAST1766

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi307 ↔ 316PROSITE-ProRule annotation
Disulfide bondi372 ↔ 381PROSITE-ProRule annotation
Disulfide bondi435 ↔ 444PROSITE-ProRule annotation
Disulfide bondi488 ↔ 497PROSITE-ProRule annotation
Disulfide bondi500 ↔ 514PROSITE-ProRule annotation
Disulfide bondi517 ↔ 529PROSITE-ProRule annotation
Disulfide bondi519 ↔ 536PROSITE-ProRule annotation
Disulfide bondi538 ↔ 547PROSITE-ProRule annotation
Disulfide bondi778 ↔ 790PROSITE-ProRule annotation
Disulfide bondi780 ↔ 797PROSITE-ProRule annotation
Disulfide bondi799 ↔ 808PROSITE-ProRule annotation
Disulfide bondi826 ↔ 838PROSITE-ProRule annotation
Disulfide bondi828 ↔ 845PROSITE-ProRule annotation
Disulfide bondi847 ↔ 856PROSITE-ProRule annotation
Disulfide bondi891 ↔ 900PROSITE-ProRule annotation
Disulfide bondi951 ↔ 960PROSITE-ProRule annotation
Disulfide bondi1005 ↔ 1014PROSITE-ProRule annotation
Disulfide bondi1062 ↔ 1071PROSITE-ProRule annotation
Disulfide bondi1090 ↔ 1102PROSITE-ProRule annotation
Disulfide bondi1092 ↔ 1109PROSITE-ProRule annotation
Disulfide bondi1111 ↔ 1120PROSITE-ProRule annotation
Disulfide bondi1138 ↔ 1150PROSITE-ProRule annotation
Disulfide bondi1140 ↔ 1157PROSITE-ProRule annotation
Disulfide bondi1159 ↔ 1168PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 277Laminin N-terminalInterPro annotationAdd BLAST240
Domaini278 – 341Laminin EGF-likeInterPro annotationAdd BLAST64
Domaini342 – 404Laminin EGF-likeInterPro annotationAdd BLAST63
Domaini405 – 464Laminin EGF-likeInterPro annotationAdd BLAST60
Domaini465 – 516Laminin EGF-likeInterPro annotationAdd BLAST52
Domaini517 – 557Laminin EGF-likeInterPro annotationAdd BLAST41
Domaini556 – 772Laminin IV type BInterPro annotationAdd BLAST217
Domaini778 – 825Laminin EGF-likeInterPro annotationAdd BLAST48
Domaini826 – 871Laminin EGF-likeInterPro annotationAdd BLAST46
Domaini872 – 921Laminin EGF-likeInterPro annotationAdd BLAST50
Domaini922 – 980Laminin EGF-likeInterPro annotationAdd BLAST59
Domaini981 – 1032Laminin EGF-likeInterPro annotationAdd BLAST52
Domaini1033 – 1089Laminin EGF-likeInterPro annotationAdd BLAST57
Domaini1090 – 1137Laminin EGF-likeInterPro annotationAdd BLAST48
Domaini1138 – 1184Laminin EGF-likeInterPro annotationAdd BLAST47

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1196 – 1216Sequence analysisAdd BLAST21
Coiled coili1257 – 1298Sequence analysisAdd BLAST42
Coiled coili1472 – 1520Sequence analysisAdd BLAST49
Coiled coili1568 – 1612Sequence analysisAdd BLAST45
Coiled coili1627 – 1654Sequence analysisAdd BLAST28
Coiled coili1719 – 1774Sequence analysisAdd BLAST56

Keywords - Domaini

Coiled coilSequence analysis, Laminin EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00780000121851

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR013015 Laminin_IV_B
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
PfamiView protein in Pfam
PF00053 Laminin_EGF, 13 hits
PF00055 Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 10 hits
SM00180 EGF_Lam, 13 hits
SM00136 LamNT, 1 hit
PROSITEiView protein in PROSITE
PS01248 EGF_LAM_1, 6 hits
PS50027 EGF_LAM_2, 13 hits
PS51116 LAMININ_IVB, 1 hit
PS51117 LAMININ_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2K6EH06-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERGRRQPLL WELRLGLLLS VLATTLAQAL APDVPGCSRG SCYPATGDLL
60 70 80 90 100
VGRADRLTAS STCGLNSPQP YCIVSHLQDE KKCFLCDSRR PFSAQDNPHS
110 120 130 140 150
HRIQNVVTSF APQRRAAWWQ SENGIPEVTI QLDLEAEFHF THLIMTFKTF
160 170 180 190 200
RPAAMLVERS ADFGRTWHVY RYFSYDCGAD FPGVPLAPPR HWDDVVCESR
210 220 230 240 250
YSEIEPSTEG EVIYRVLDPA IPIPDPYSSR IQNLLKITNL RVNLTRLHTL
260 270 280 290 300
GDNLLDPRRE IREKYYYALY ELVVRGNCFC YGHASQCAPA PGAPAHAEGM
310 320 330 340 350
VHGACICKHN TRGLNCEQCQ DFYHDLPWHP AEDGHSHACR KCECHGHTRS
360 370 380 390 400
CHFDMAIYLA SGNVSGGVCD GCQHNTAGHH CELCRPFFYR DPTKDLQDPA
410 420 430 440 450
VCRSCDCDPM GSQDGGRCDS HDDPALGLVS GQCRCKEHVV GTRCQQCRDG
460 470 480 490 500
FFGLSASDPL GCQRCQCNTR GTVPGGTPCD PKSGTCFCKR LVTGHGCNHC
510 520 530 540 550
LPGHWGLSHD LLGCRPCDCD VGGALDPQCN EATGQCRCRQ HMVGRRCEQV
560 570 580 590 600
QPGYFRPFLD HLTWEAEDAR GQVLDVVERL VTTQETPSWT GSGFVRLREG
610 620 630 640 650
QVLEFLVASV PRAMDYDLLL RLEPQVPEQW AEMELTVQRP GPVPAHSPCG
660 670 680 690 700
HVLPKDDHIQ GTLQPDTRYM VFPSPVCLEP GISYKLHLKL VRTGGSTQPE
710 720 730 740 750
TPYSGPGLLI DSLVLLPRVL VLEMFSGGDA AALERHATFE HYRCHEEGLV
760 770 780 790 800
PRKTPPSEAC APLLISLSTQ IYNGALPCQC NPQGSLSSEC NPHGGQCLCK
810 820 830 840 850
PGVVGRRCDL CAPGYYGFGP TGCQACQCSP EGALSSLCEG TSGQCPCRTG
860 870 880 890 900
AFGLRCDRCQ RGQWGFPSCR PCACNGRADE CDTHTGACLG CRDHTGGEHC
910 920 930 940 950
ERCIAGFHGD PRLPYGGQCR PCPCPEGPGS QRHFATSCHR DEYSQQIVCH
960 970 980 990 1000
CRAGYTGLRC EACAPGHFGD PSRPGGRCQL CECSGNIDPM DPDACDPHTG
1010 1020 1030 1040 1050
QCLRCLHHTE GPHCAHCKPG FHGQATRQSC HRCTCNLLGT NPQQCPSADR
1060 1070 1080 1090 1100
CQCDPSSGQC PCLPNVQGLS CDRCAPNFWN LTSGHGCQPC ACHLSRARGP
1110 1120 1130 1140 1150
TCNEFTGQCH CRAGFGGRTC SECQELHWGD PGLQCRACDC DPRGIDTPQC
1160 1170 1180 1190 1200
HRSTGHCSCR PGVSGVRCNQ CARGFSGVFP ACHPCHACFG DWDRVVQDLA
1210 1220 1230 1240 1250
TRTRRLEQRA QDLQQTGVLG AFESSFRHMQ EKLGTVQGIV GAHNTSAAST
1260 1270 1280 1290 1300
AQLVKATEEL RREIGEATEH LTQLEAELTD VQDENFNANH ALSDLERDGL
1310 1320 1330 1340 1350
ALNLTLRQLD QHLDLLKHSN FLGAYDSIRH AHSQSAEAER RANTSALAVP
1360 1370 1380 1390 1400
SPVSNSAGIR HRTEVLMDAR REDFNSKHMA NQRALDELSA RTHTLSLTGI
1410 1420 1430 1440 1450
NELVCGAPGD APCATSPCGG AGCRDEDGQP RCGGLSCNGA AATADLALGR
1460 1470 1480 1490 1500
ARHTQAELQR ALTEGGGILS QVAETRRQAG EAQQRAQAAL DKANASRGQV
1510 1520 1530 1540 1550
EQTNQELREL IQSVKDFLNQ EGADPDSIEM VATRVLELSI PASPEQIQHL
1560 1570 1580 1590 1600
AGAIAERVRS LADVDMILAR TMGDVRRAEQ LLQDAQRARN RAEGEKQKAA
1610 1620 1630 1640 1650
TVQAALEEAQ RAQNAAQGAI RGAVADTQDT EQTLHQVQER MAGAEQALSS
1660 1670 1680 1690 1700
AGERARQLDA LLEALKLKRA GNSLAASTAE ETAGSAQGRA REAEQLLQGP
1710 1720 1730 1740 1750
LGDQYQTVKA LAERKAQGVL AAQARAEQLR DEARDLLQAA QDKLQRLQEL
1760 1770 1780 1790
EDTYEENERA LEGKAAQLDG LEARMRSVLQ AINLQVQIYN TCQ
Length:1,793
Mass (Da):195,529
Last modified:March 28, 2018 - v1
Checksum:i105B10B2CBD51DDB
GO

Sequence databases

RefSeqiXP_012520852.1, XM_012665398.1

Genome annotation databases

EnsembliENSPCOT00000003624; ENSPCOP00000001013; ENSPCOG00000003248
GeneIDi105827311

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_012520852.1, XM_012665398.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPCOT00000003624; ENSPCOP00000001013; ENSPCOG00000003248
GeneIDi105827311

Organism-specific databases

CTDi3913

Phylogenomic databases

GeneTreeiENSGT00780000121851

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR013015 Laminin_IV_B
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
PfamiView protein in Pfam
PF00053 Laminin_EGF, 13 hits
PF00055 Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 10 hits
SM00180 EGF_Lam, 13 hits
SM00136 LamNT, 1 hit
PROSITEiView protein in PROSITE
PS01248 EGF_LAM_1, 6 hits
PS50027 EGF_LAM_2, 13 hits
PS51116 LAMININ_IVB, 1 hit
PS51117 LAMININ_NTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2K6EH06_PROCO
AccessioniPrimary (citable) accession number: A0A2K6EH06
Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: October 10, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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