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Protein
Submitted name:

Sidekick cell adhesion molecule 2

Gene

SDK2

Organism
Macaca nemestrina (Pig-tailed macaque)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Sidekick cell adhesion molecule 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SDK2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacaca nemestrina (Pig-tailed macaque)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9545 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000233120 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Whole Genome Shotgun Assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1930 – 1953HelicalSequence analysisAdd BLAST24

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501433119421 – 2172Sequence analysisAdd BLAST2152

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 108Ig-likeInterPro annotationAdd BLAST83
Domaini141 – 200Ig-likeInterPro annotationAdd BLAST60
Domaini215 – 294Ig-likeInterPro annotationAdd BLAST80
Domaini308 – 396Ig-likeInterPro annotationAdd BLAST89
Domaini402 – 491Ig-likeInterPro annotationAdd BLAST90
Domaini496 – 585Ig-likeInterPro annotationAdd BLAST90
Domaini592 – 688Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini693 – 789Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini794 – 893Fibronectin type-IIIInterPro annotationAdd BLAST100
Domaini897 – 991Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini995 – 1094Fibronectin type-IIIInterPro annotationAdd BLAST100
Domaini1099 – 1197Fibronectin type-IIIInterPro annotationAdd BLAST99
Domaini1202 – 1299Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini1303 – 1397Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini1402 – 1499Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini1504 – 1621Fibronectin type-IIIInterPro annotationAdd BLAST118
Domaini1626 – 1722Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini1726 – 1821Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini1824 – 1923Fibronectin type-IIIInterPro annotationAdd BLAST100

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155761

Database of Orthologous Groups

More...
OrthoDBi
134749at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 13 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 19 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 13 hits
PF07679 I-set, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 13 hits
SM00409 IG, 6 hits
SM00408 IGc2, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 5 hits
SSF49265 SSF49265, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 13 hits
PS50835 IG_LIKE, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2K6DS99-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWGFLIWTLL TLHQIRAARA QDDVSPYFKT EPVRTQVHLE GNRLVLTCMA
60 70 80 90 100
EGSWPLEFKW LHNSRELTKF SLEYRYMITS LDRTHAGFYR CIVRNRMGAL
110 120 130 140 150
LQRQTEVQVA YMGSFEEGEK HQSVSHGEAA VIHAPRIASF PRPQVTWFRD
160 170 180 190 200
GRKIPPSSRI AITLENTLVI LSTVAPDAGR YYVQAVNDKN GDNKTSQPIT
210 220 230 240 250
LAVENVGGPA DPIAPTIIIP PKNTSVVAGT SEVTLECVAN ARPLIKLHII
260 270 280 290 300
WKKDGMLLSG GISDHNRRLT IPNPTGSDAG YYECEAVLRS SSVPSVVRGA
310 320 330 340 350
YLSVLEPPQF VKEPERHITA EMEKVVDIPC RAKGVPPPSI TWYKDAAVVE
360 370 380 390 400
VEKLARFRQR SDGGLQISGL VPDDTGMFQC FARNAAGEVQ TSTYLAVTSI
410 420 430 440 450
APNITRGPLD STVIDGMSVV LACETSGAPR PAITWQKGER ILASGSVQLP
460 470 480 490 500
RFTPLESGSL LISPTHISDA GTYTCLATNS RGVDEASADL VVWARTRITK
510 520 530 540 550
PPQDQSVIKG TQASMVCGVS HDPRVTVRYI WEKDGATLGV ESNPRIRLDR
560 570 580 590 600
NGSLHISQTW SGDIGTYTCR VISAGGNDSR SAHLRVRQLP HAPEHPVATL
610 620 630 640 650
STVERRAINL TWTKPFDGNS PLLRYVLEMS ENNAPWTILL ASVDPKATSV
660 670 680 690 700
TVKGLVPARS YQFRLCAVND VGKGQFSKDT ERVSLPEEPP TAPPQNVIAS
710 720 730 740 750
GRTNQSIMIQ WQPPPESHQN GILKGYIIRY CLAGLPVGYQ FKNITDADVN
760 770 780 790 800
NLLLEDLIIW TNYEIEVAAY NSAGLGVYSS KVTEWTLQGV PTVPPGNVHA
810 820 830 840 850
EATNSTTIRF TWNAPSPQFI NGINQGYKLI AWEPEQEEEV TMVTARPNFQ
860 870 880 890 900
DSIHVGFVSG LKKFTEYFTS VLCFTTPGDG PRSAPQLVRT HEDVPGPVGH
910 920 930 940 950
LSFSEILDTS LKVSWQEPGE KNGILTGYRI SWEEYNRTNT RVTHYLPNVT
960 970 980 990 1000
LEYRVTGLTA LTTYTIEVAA MTSKGQGQVS ASTISSGVPP ELPGPPTNLG
1010 1020 1030 1040 1050
ISNIGPRSVT LQFRPGYDGK TSISRWLVEA QVGVVGEGEE WLLIHQLSNE
1060 1070 1080 1090 1100
PDARSMEVPD LNPFTYYSFR MRQVNIVGTS PPSQPSRKIQ TLQAPPDMAP
1110 1120 1130 1140 1150
ANVSLRTASE TSLWLRWMPL PEMEYNGNPE SVGYKIKYSR SDGHGKTLSH
1160 1170 1180 1190 1200
VVQDRVEREY TIEDLEEWTE YRVQVQAFNA IGSGPWSQTV VGRTRESVPS
1210 1220 1230 1240 1250
SGPTNVSALA TTSSSMLVRW SEVPEADRNG LVLGYKVIYK EKDSDAQPRF
1260 1270 1280 1290 1300
WLVEGNSSRS AQLTGLGKYV LYEVQVLAFT RIGDGSPSHP PILERTLDDV
1310 1320 1330 1340 1350
PGPPMGILFP EVRTTSVRLI WQPPAAPNGI ILAYQITHRL NTTTANTATV
1360 1370 1380 1390 1400
EVLAPSARQY TATGLKPESV YLFRITAQTR KGWGDAAEAL VVTTEKRDRP
1410 1420 1430 1440 1450
QPPSRPVVQQ EDVRARSVLL SWEPGSDGLS PVRYYTIQTR ELPSGRWTLH
1460 1470 1480 1490 1500
SASVSHNASS FIVDRLKPFT SYKFRVKATN DIGDSEFSEE SESLTTLQAA
1510 1520 1530 1540 1550
PDEAPTILSV TPHTTTSVLI RWQPPAEDKI NGILLGFRIR YRELLYEGLR
1560 1570 1580 1590 1600
GFTLRGINNP GATWAELTSM YSMRNLSRPS LTQYELDNLN KHRRYEIRMS
1610 1620 1630 1640 1650
VYNAVGEGPS STPQEVFVGE AVPTAAPRNV VVHGATATQL DVTWEPPPLD
1660 1670 1680 1690 1700
SHNGDIQGYK IYFWEAQRGN FTERVKTLFL AENSVKLKNL TGYTAYMVSV
1710 1720 1730 1740 1750
AAFNAAGDGP RSTPTQGQTQ QAAPSAPSSV KFSELTTTSV NVSWEAPQFP
1760 1770 1780 1790 1800
NGILEGYRLV YEPCSPVDGV SKIVTVDVKG NSPLWLKVKD LAEGVTYRFR
1810 1820 1830 1840 1850
IRAKTFTYGP EIEANVTTGP GEGAPGPPGV PIIVRYSSAI AIHWSSGDPG
1860 1870 1880 1890 1900
KGPITRYVIE ARPSDEGLWD ILIKDIPKEV SSYTFSMDIL KPGVSYDFRV
1910 1920 1930 1940 1950
IAVNDYGFGT PSSPSQSVPA QKANPFYEEW WFLVVIALVG LIFILLLVFV
1960 1970 1980 1990 2000
LIIRGQSKKY AKKTDSGNSA KSGALGHSEM MSLDESSFPA LELNNRRLSV
2010 2020 2030 2040 2050
KNSFCRKNGL YTRSPPRPSP GSLHYSDEDV TKYNDLIPAE SSSLTEKPSE
2060 2070 2080 2090 2100
ISDSQGSDSE YEVDSNHQKA HSFVNHYISD PTYYNSWRRQ QKGISRAQAY
2110 2120 2130 2140 2150
SYTESDSGEP DHAAVTNSTS TQQGSLFRPK ASRTPTPQNP PNPPSQQSTL
2160 2170
YRPPSSLAPG SRAPIAGFSS FV
Length:2,172
Mass (Da):239,329
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3C3C160EAF26939B
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_011717998.1, XM_011719696.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMNET00000063286; ENSMNEP00000038803; ENSMNEG00000042378

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
105469102

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_011717998.1, XM_011719696.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMNET00000063286; ENSMNEP00000038803; ENSMNEG00000042378
GeneIDi105469102

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54549

Phylogenomic databases

GeneTreeiENSGT00940000155761
OrthoDBi134749at2759

Family and domain databases

CDDicd00063 FN3, 13 hits
Gene3Di2.60.40.10, 19 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 13 hits
PF07679 I-set, 4 hits
SMARTiView protein in SMART
SM00060 FN3, 13 hits
SM00409 IG, 6 hits
SM00408 IGc2, 6 hits
SUPFAMiSSF48726 SSF48726, 5 hits
SSF49265 SSF49265, 7 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 13 hits
PS50835 IG_LIKE, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K6DS99_MACNE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K6DS99
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: January 16, 2019
This is version 10 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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