Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 8 (31 Jul 2019)
Sequence version 1 (28 Mar 2018)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Anion exchange protein

Gene

SLC4A2

Organism
Macaca nemestrina (Pig-tailed macaque)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transportUniRule annotation, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Anion exchange proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC4A2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacaca nemestrina (Pig-tailed macaque)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9545 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000233120 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Whole Genome Shotgun Assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei706 – 727HelicalUniRule annotationAdd BLAST22
Transmembranei748 – 771HelicalUniRule annotationAdd BLAST24
Transmembranei791 – 816HelicalUniRule annotationAdd BLAST26
Transmembranei823 – 841HelicalUniRule annotationAdd BLAST19
Transmembranei898 – 915HelicalUniRule annotationAdd BLAST18
Transmembranei931 – 951HelicalUniRule annotationAdd BLAST21
Transmembranei988 – 1007HelicalUniRule annotationAdd BLAST20
Transmembranei1028 – 1052HelicalUniRule annotationAdd BLAST25
Transmembranei1088 – 1107HelicalUniRule annotationAdd BLAST20
Transmembranei1113 – 1133HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini349 – 616Band_3_cytoInterPro annotationAdd BLAST268
Domaini672 – 1165HCO3_cotranspInterPro annotationAdd BLAST494

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 245DisorderedSequence analysisAdd BLAST245
Regioni284 – 317DisorderedSequence analysisAdd BLAST34
Regioni446 – 466DisorderedSequence analysisAdd BLAST21
Regioni476 – 495DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi32 – 99PolyampholyteSequence analysisAdd BLAST68
Compositional biasi141 – 157PolarSequence analysisAdd BLAST17
Compositional biasi303 – 317PolyampholyteSequence analysisAdd BLAST15

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158259

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.930.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001717 Anion_exchange
IPR002978 Anion_exchange_2
IPR018241 Anion_exchange_CS
IPR013769 Band3_cytoplasmic_dom
IPR011531 HCO3_transpt_C
IPR003020 HCO3_transpt_euk
IPR016152 PTrfase/Anion_transptr

The PANTHER Classification System

More...
PANTHERi
PTHR11453 PTHR11453, 1 hit
PTHR11453:SF14 PTHR11453:SF14, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07565 Band_3_cyto, 1 hit
PF00955 HCO3_cotransp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00165 ANIONEXCHNGR
PR01188 ANIONEXHNGR2
PR01231 HCO3TRNSPORT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55804 SSF55804, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00834 ae, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00219 ANION_EXCHANGER_1, 1 hit
PS00220 ANION_EXCHANGER_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A2K6DHG0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSAPRCPTK GADSFRTPEP ESLGPGTPGF PEQEEDELHR TLGVERFEEI
60 70 80 90 100
LHEAGSRGGE EPGRSYGEED FEYHRQSSHH IHHPLSTHLP PDARRRKTPQ
110 120 130 140 150
GPGRKPRRRP GASPTGETPT IEEGEEDEDE AIEAEGARAV TQPSPASTPS
160 170 180 190 200
SVQFFLQEDD SADRKAERTS PSSPAPLPHQ EATPRASKGA QAGTQVEEAV
210 220 230 240 250
AVVASGTAGG DDGGASGRPL PKAQPGHRSY NLQERRRIGS MTGAEQALLP
260 270 280 290 300
RVPTDESEAQ TLATADLDLM KSHRFEDVPG VRRHLVRKNA KGSTQSGREG
310 320 330 340 350
REPGPTPRAR PRAPHKPHEV FVELNELLLD KNQEPQWRET ARWIKFEEDV
360 370 380 390 400
EEETERWGKP HVASLSFRSL LELRRTLAHG AVLLDLDQQT LPGVAHQVVE
410 420 430 440 450
QMVISDQIKA EDRANVLRAL LLKHSHPSDE KDFSFPRNIS AGSLGSLLGH
460 470 480 490 500
HHGQGAESDP HVTEPLIGGV PETRLEVERE RELPPPAPPG GITRSKSKHE
510 520 530 540 550
LKLLEKIPEN AEATVVLVGC VEFLSRPTMA FVRLREAVEL DAVLEVPVPV
560 570 580 590 600
RFLFLLLGPS SANMDYHEIG RSISTLMSDK QFHEAAYLAD ERDDLLTAIN
610 620 630 640 650
AFLDCSVVLP PSEVQGEELL RSVAHFQRQM LKKREEQGRL LPTGAGLEPK
660 670 680 690 700
SAQDKALLQM VEAAGAAEDD PLRRTGRPFG GLIRDVRRRY PHYLSDFRDA
710 720 730 740 750
LDPQCLAAVI FIYFAALSPA ITFGGLLGEK TQDLIGVSEL IMSTALQGVV
760 770 780 790 800
FCLLGAQPLL VIGFSGPLLV FEEAFFSFCS SNHLEYLVGR VWIGFWLVLL
810 820 830 840 850
ALLMVALEGS FLVRFVSRFT QEIFAFLISL IFIYETFYKL VKIFQEHPLH
860 870 880 890 900
GCSASNSSEV DGGENMTWAG ARPTLGPGNR SLAGQSGQGK PRGQPNTALL
910 920 930 940 950
SLVLMAGTFF IAFFLRKFKN SRFFPGRIRR VIGDFGVPIA ILIMVLVDYS
960 970 980 990 1000
IEDTYTQKLS VPSGFSVTAP EKRGWVINPL GEKSPFPVWM MVASLLPAIL
1010 1020 1030 1040 1050
VFILIFMETQ ITTLIISKKE RMLQKGSGFH LDLLLIVAMG GICALFGLPW
1060 1070 1080 1090 1100
LAAATVRSVT HANALTVMSK AVAPGDKPKI QEVKEQRVTG LLVALLVGLS
1110 1120 1130 1140 1150
IVIGDLLRQI PLAVLFGIFL YMGVTSLNGI QFYERLHLLL MPPKHHPDVT
1160 1170 1180 1190 1200
YVKKVRTLRM HLFTALQLLC LALLWAVMST AASLAFPFIL ILTVPLRMVV
1210 1220 1230 1240
LTRIFTEREM KCVSPPACLP QSLLPPCGSG KVPHPPLPFL TTPHPTVGC
Length:1,249
Mass (Da):137,386
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0D151CE12035C7A1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K6DHG7A0A2K6DHG7_MACNE
Anion exchange protein
SLC4A2
1,238Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K6DHK4A0A2K6DHK4_MACNE
Anion exchange protein
SLC4A2
1,224Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K6DHK1A0A2K6DHK1_MACNE
Anion exchange protein
SLC4A2
1,155Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMNET00000059829; ENSMNEP00000035372; ENSMNEG00000040841

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMNET00000059829; ENSMNEP00000035372; ENSMNEG00000040841

Phylogenomic databases

GeneTreeiENSGT00940000158259

Family and domain databases

Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR001717 Anion_exchange
IPR002978 Anion_exchange_2
IPR018241 Anion_exchange_CS
IPR013769 Band3_cytoplasmic_dom
IPR011531 HCO3_transpt_C
IPR003020 HCO3_transpt_euk
IPR016152 PTrfase/Anion_transptr
PANTHERiPTHR11453 PTHR11453, 1 hit
PTHR11453:SF14 PTHR11453:SF14, 1 hit
PfamiView protein in Pfam
PF07565 Band_3_cyto, 1 hit
PF00955 HCO3_cotransp, 1 hit
PRINTSiPR00165 ANIONEXCHNGR
PR01188 ANIONEXHNGR2
PR01231 HCO3TRNSPORT
SUPFAMiSSF55804 SSF55804, 1 hit
TIGRFAMsiTIGR00834 ae, 1 hit
PROSITEiView protein in PROSITE
PS00219 ANION_EXCHANGER_1, 1 hit
PS00220 ANION_EXCHANGER_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K6DHG0_MACNE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K6DHG0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: July 31, 2019
This is version 8 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again