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Protein
Submitted name:

Uncharacterized protein

Gene

ADGRG6

Organism
Macaca nemestrina (Pig-tailed macaque)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:ADGRG6Imported
OrganismiMacaca nemestrina (Pig-tailed macaque)Imported
Taxonomic identifieri9545 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000233120 Componenti: Whole Genome Shotgun Assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei865 – 888HelicalSequence analysisAdd BLAST24
Transmembranei900 – 921HelicalSequence analysisAdd BLAST22
Transmembranei927 – 949HelicalSequence analysisAdd BLAST23
Transmembranei969 – 990HelicalSequence analysisAdd BLAST22
Transmembranei1018 – 1044HelicalSequence analysisAdd BLAST27
Transmembranei1065 – 1087HelicalSequence analysisAdd BLAST23
Transmembranei1093 – 1116HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 37Sequence analysisAdd BLAST37
ChainiPRO_501432109238 – 1249Sequence analysisAdd BLAST1212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi94 ↔ 111PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 149CUBInterPro annotationAdd BLAST109
Domaini799 – 851GPSInterPro annotationAdd BLAST53
Domaini863 – 1117G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST255

Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00930000150821

Family and domain databases

CDDicd00041 CUB, 1 hit
Gene3Di2.60.120.290, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000859 CUB_dom
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR001759 Pentraxin-related
IPR035914 Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF00431 CUB, 1 hit
PF01825 GPS, 1 hit
PF00354 Pentaxin, 1 hit
PRINTSiPR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00042 CUB, 1 hit
SM00303 GPS, 1 hit
SM00159 PTX, 1 hit
SUPFAMiSSF49854 SSF49854, 1 hit
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS51828 PTX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A2K6D7H2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMFRSDRMWS CHWKWKPSPL LFLFALYIMC VPHSVWGCAN CRVVLSNPSG
60 70 80 90 100
TFTSPCYPND YPNSQACMWT LRAPTGYIIQ ITFNDFDIEE APNCIYDSLS
110 120 130 140 150
LDNGESQTKF CGATAKGLSF NSSANEMHVS FSSDFSIQKK GFNASYIRVA
160 170 180 190 200
VSLRNQKVIL PQISDAYQVS VAKSVSIPEL SAFTLCFEAT KVGHEDNDWT
210 220 230 240 250
AFSYSNASFT QLLSFGKAKS GYFLSISDSK CLLNNALPVK EKEDIFAESF
260 270 280 290 300
EQLCLVWNNS LGSIGVNFKR NYETVPCDST ISKVIPGNGK LLLGSNQNEI
310 320 330 340 350
VSLKGDIYNF RLWNFTMNAK ILSNLSCNMK GNVVDWQNDF WNIPNLALKA
360 370 380 390 400
ESNLSCGSYL IPLPAAELAS CADLGTLCQA TVNSPSTTPP TVTTNMPVTN
410 420 430 440 450
RIDKQRNDGI IYRISVVIQN ILRHPEVKVQ SKVAEWLNST FENWNYTVYV
460 470 480 490 500
INISFHLSGG EDKIKVKRSI ENEPRLVLWA LLVYNATNNT NLEGKIIQQK
510 520 530 540 550
LLKNNESLDE GLRLHTVNVR QLGYCLAVEE PKGYYWPSIQ PSEYVLPCPD
560 570 580 590 600
KPDFSASRIC YDNATNPSVA YWGPPDISSC SKANEVANQI LDLTADGQNL
610 620 630 640 650
TSANITNIVE QVKRIVNKEE NIDITLGSTL MNIFSNILSS SDSDLLESSS
660 670 680 690 700
EALKTIDELA FKIDLNSTSH VNITTRNLAL GVSSLLPGTN AISNFSIGLP
710 720 730 740 750
SNNESYFQMD FESGQVDPLA SVILPPNLLE NLSQEDSVLV RRAQFTFFNK
760 770 780 790 800
TGLFQDVGPQ RKTLVSYVMA CSIGNITIQN LKDPVQIKIK HTRTQEVHHP
810 820 830 840 850
ICAFWDLNKN KSFGGWNTSG CVAHRDSDAS ETVCLCNHFT HFGVLMDLPR
860 870 880 890 900
SASQLDARNT KVLTFISYIG CGISAIFSAA TLLTYVAFEK LRRDYPSKIL
910 920 930 940 950
MNLSAALLFL NLLFLLDGWI TSFNVDGLCI AVAVLLHFFL LATFTWMGLE
960 970 980 990 1000
AIHMYIALVK VFNTYIRRYI LKFCIIGWGL PALVVSIVLA SRNKNEVYGK
1010 1020 1030 1040 1050
ESYGKEKGDE FCWIQDPVIF YVTCAGYFGV MFFLNIAMFI VVMVQICGRN
1060 1070 1080 1090 1100
GKRSNRTLRE EVLRNLRSVV SLTFLLGMTW GFAFFAWGPL NIAFMYLFSI
1110 1120 1130 1140 1150
FNSLQGLFIF IFHCAMKENV QKQWRRHLCC GRFRLADNSD WSKTATNIIK
1160 1170 1180 1190 1200
KSSDNLGKSL SSSSIGSNST YLTSKSKSSS TTYFKRNSHT DNASMDKSLS
1210 1220 1230 1240
KLAHADGDQT SIIPVHQVID KVKGYCNAHS DNFYKNIIMS DTFSHSTKF
Length:1,249
Mass (Da):139,767
Last modified:March 28, 2018 - v1
Checksum:iEBFFD5B9EA0F33F9
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K6D7E6A0A2K6D7E6_MACNE
Uncharacterized protein
ADGRG6
1,220Annotation score:
A0A2K6D7I9A0A2K6D7I9_MACNE
Uncharacterized protein
ADGRG6
1,198Annotation score:
A0A2K6D7J8A0A2K6D7J8_MACNE
Uncharacterized protein
ADGRG6
557Annotation score:

Sequence databases

RefSeqiXP_011712616.1, XM_011714314.1

Genome annotation databases

EnsembliENSMNET00000056286; ENSMNEP00000031854; ENSMNEG00000039210
GeneIDi105465745

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_011712616.1, XM_011714314.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMNET00000056286; ENSMNEP00000031854; ENSMNEG00000039210
GeneIDi105465745

Organism-specific databases

CTDi57211

Phylogenomic databases

GeneTreeiENSGT00930000150821

Family and domain databases

CDDicd00041 CUB, 1 hit
Gene3Di2.60.120.290, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000859 CUB_dom
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR001759 Pentraxin-related
IPR035914 Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF00431 CUB, 1 hit
PF01825 GPS, 1 hit
PF00354 Pentaxin, 1 hit
PRINTSiPR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00042 CUB, 1 hit
SM00303 GPS, 1 hit
SM00159 PTX, 1 hit
SUPFAMiSSF49854 SSF49854, 1 hit
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS51828 PTX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2K6D7H2_MACNE
AccessioniPrimary (citable) accession number: A0A2K6D7H2
Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: November 7, 2018
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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