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Protein

Claudin

Gene

CLDN4

Organism
Macaca nemestrina (Pig-tailed macaque)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
ClaudinUniRule annotation
Gene namesi
Name:CLDN4Imported
OrganismiMacaca nemestrina (Pig-tailed macaque)Imported
Taxonomic identifieri9545 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000233120 Componenti: Whole Genome Shotgun Assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei79 – 99HelicalUniRule annotationAdd BLAST21
Transmembranei119 – 140HelicalUniRule annotationAdd BLAST22
Transmembranei160 – 183HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Cell junction, Cell membraneUniRule annotationSAAS annotation, Membrane, Tight junctionUniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118928

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003550 Claudin4
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01379 CLAUDIN4
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2K6CYJ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASMGLQVTG IALAVLGWLA VMLCCALPMW RVTAFIGSNI VTSQTIWEGL
60 70 80 90 100
WMNCVVQSTG QMQCKVYDSL LALPQDLQAA RALVIISIIV AALGVLLSVV
110 120 130 140 150
GGKCTNCLED ESAKAKTMIV AGVVFLLAGL LVIVPVSWTA HNIIQDFYNP
160 170 180 190 200
LVASGQKREM GASLYVGWAA SGLLLLGGGL LCCNCPPRTD KPYSAKYSAA

RSAAASNYV
Length:209
Mass (Da):22,029
Last modified:March 28, 2018 - v1
Checksum:i474DB3099F95289E
GO

Sequence databases

RefSeqiXP_011713660.1, XM_011715358.1

Genome annotation databases

EnsembliENSMNET00000053088; ENSMNEP00000028732; ENSMNEG00000037828
GeneIDi105466374

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_011713660.1, XM_011715358.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMNET00000053088; ENSMNEP00000028732; ENSMNEG00000037828
GeneIDi105466374

Organism-specific databases

CTDi1364

Phylogenomic databases

GeneTreeiENSGT00760000118928

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003550 Claudin4
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01379 CLAUDIN4
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2K6CYJ4_MACNE
AccessioniPrimary (citable) accession number: A0A2K6CYJ4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: November 7, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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