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Protein

Protein-tyrosine sulfotransferase

Gene

TPST1

Organism
Macaca nemestrina (Pig-tailed macaque)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.UniRule annotation

Catalytic activityi

3'-phosphoadenylyl sulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-tyrosine sulfotransferaseUniRule annotation (EC:2.8.2.20UniRule annotation)
Gene namesi
Name:TPST1Imported
OrganismiMacaca nemestrina (Pig-tailed macaque)Imported
Taxonomic identifieri9545 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000233120 Componenti: Whole Genome Shotgun Assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Belongs to the protein sulfotransferase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000006030

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR026634 TPST
PANTHERiPTHR12788 PTHR12788, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A2K6CSB1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGKLKQNLL LACLVISSVT VFYLGQHAME CHHRIEERSQ PVKLESTRTT
60 70 80 90 100
VRTGLDLKAN KTFAYHKDMP LIFIGGVPRS GTTLMRAMLD AHPDIRCGEE
110 120 130 140 150
TRVIPRILAL KQMWSRSSKE KIRLDEAGVT DEVLDSAMQA FLLEIIVKHG
160 170 180 190 200
EPAPYLCNKD PFALKSLTYL ARLFPNAKFL LMVRDGRASV HSMISRKVTI
210 220 230 240 250
AGFDLNSYRD CLTKWNRAIE TMYNQCMEVG YKKCMLVHYE QLVLHPERWM
260 270 280 290 300
RTLLKFLQIP WNHSVLHHEE MIGKAGGVSL SKVERSTDQV IKPVNVAALS
310 320 330 340 350
KWVGKIPPDV LQDMAVIAPM LAKLGYDPYA NPPNYGKPDP KILENTRRVY
360 370
KGEFQLPDFL KEKPQTEQVE
Length:370
Mass (Da):42,186
Last modified:March 28, 2018 - v1
Checksum:i16ABEF33D515ECD3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K6CSH8A0A2K6CSH8_MACNE
Protein-tyrosine sulfotransferase
TPST1
368Annotation score:

Sequence databases

RefSeqiXP_011713609.1, XM_011715307.1
XP_011713611.1, XM_011715309.1
XP_011713612.1, XM_011715310.1

Genome annotation databases

EnsembliENSMNET00000050836; ENSMNEP00000026550; ENSMNEG00000036719
GeneIDi105466322

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_011713609.1, XM_011715307.1
XP_011713611.1, XM_011715309.1
XP_011713612.1, XM_011715310.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMNET00000050836; ENSMNEP00000026550; ENSMNEG00000036719
GeneIDi105466322

Organism-specific databases

CTDi8460

Phylogenomic databases

GeneTreeiENSGT00390000006030

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR026634 TPST
PANTHERiPTHR12788 PTHR12788, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2K6CSB1_MACNE
AccessioniPrimary (citable) accession number: A0A2K6CSB1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: November 7, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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