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Protein

Tissue factor pathway inhibitor

Gene

TFPI

Organism
Macaca nemestrina (Pig-tailed macaque)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei64 – 65Reactive bondUniRule annotation2
Sitei135 – 136Reactive bondUniRule annotation2
Sitei227 – 228Reactive bondUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitorUniRule annotation
Biological processBlood coagulationUniRule annotation, Hemostasis

Names & Taxonomyi

Protein namesi
Recommended name:
Tissue factor pathway inhibitorUniRule annotation
Gene namesi
Name:TFPIImported
OrganismiMacaca nemestrina (Pig-tailed macaque)Imported
Taxonomic identifieri9545 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000233120 Componenti: Whole Genome Shotgun Assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28UniRule annotationAdd BLAST28
ChainiPRO_501421294329 – 304Tissue factor pathway inhibitorUniRule annotationAdd BLAST276

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 104BPTI/Kunitz inhibitorInterPro annotationAdd BLAST51
Domaini125 – 175BPTI/Kunitz inhibitorInterPro annotationAdd BLAST51
Domaini217 – 267BPTI/Kunitz inhibitorInterPro annotationAdd BLAST51

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00740000114929

Family and domain databases

CDDicd00109 KU, 3 hits
Gene3Di4.10.410.10, 3 hits
InterProiView protein in InterPro
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR020901 Prtase_inh_Kunz-CS
IPR008296 TFPI-like
IPR029864 TFPI1
PANTHERiPTHR10083:SF317 PTHR10083:SF317, 1 hit
PfamiView protein in Pfam
PF00014 Kunitz_BPTI, 3 hits
PIRSFiPIRSF001620 TFPI, 1 hit
PRINTSiPR00759 BASICPTASE
SMARTiView protein in SMART
SM00131 KU, 3 hits
SUPFAMiSSF57362 SSF57362, 3 hits
PROSITEiView protein in PROSITE
PS00280 BPTI_KUNITZ_1, 3 hits
PS50279 BPTI_KUNITZ_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A2K6CMM4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIYTMKKVHA LWVSICLMLN LAPAPLNADS EEDEEYTIIT DTELPPLKLM
60 70 80 90 100
HSFCAFKPDD GPCKAIMKRF FFNIFTRQCE EFIYGGCGGN QNRFESMEEC
110 120 130 140 150
KKVCTRDNVN RIIQTALQQE KPDFCFLEED PGICRGYITR YFYNNQSKQC
160 170 180 190 200
ERFKYGGCLG NMNNFETLEE CKNTCEDGLN GFQVDNYGTQ LNAVNNSQTP
210 220 230 240 250
QSTKVPSFFE FHGPSWCLAP ADRGLCRANE NRFYYNSVIG KCRPFKYSGC
260 270 280 290 300
GGNENNFTSK RECLRACKKG FIQRISKGGL IKTKRKRKKQ RVKIAYEEVF

VKNM
Length:304
Mass (Da):35,062
Last modified:March 28, 2018 - v1
Checksum:iB8E6A704535B1E8B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K6CMM5A0A2K6CMM5_MACNE
Tissue factor pathway inhibitor
TFPI
251Annotation score:

Sequence databases

RefSeqiXP_011716655.1, XM_011718353.1

Genome annotation databases

EnsembliENSMNET00000049175; ENSMNEP00000024903; ENSMNEG00000035955
GeneIDi105468250

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_011716655.1, XM_011718353.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMNET00000049175; ENSMNEP00000024903; ENSMNEG00000035955
GeneIDi105468250

Organism-specific databases

CTDi7035

Phylogenomic databases

GeneTreeiENSGT00740000114929

Family and domain databases

CDDicd00109 KU, 3 hits
Gene3Di4.10.410.10, 3 hits
InterProiView protein in InterPro
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR020901 Prtase_inh_Kunz-CS
IPR008296 TFPI-like
IPR029864 TFPI1
PANTHERiPTHR10083:SF317 PTHR10083:SF317, 1 hit
PfamiView protein in Pfam
PF00014 Kunitz_BPTI, 3 hits
PIRSFiPIRSF001620 TFPI, 1 hit
PRINTSiPR00759 BASICPTASE
SMARTiView protein in SMART
SM00131 KU, 3 hits
SUPFAMiSSF57362 SSF57362, 3 hits
PROSITEiView protein in PROSITE
PS00280 BPTI_KUNITZ_1, 3 hits
PS50279 BPTI_KUNITZ_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2K6CMM4_MACNE
AccessioniPrimary (citable) accession number: A0A2K6CMM4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: September 12, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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