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Protein

Deoxyribonuclease

Gene

DNASE1

Organism
Macaca nemestrina (Pig-tailed macaque)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei100UniRule annotation1
Active sitei162UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonucleaseUniRule annotation, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
DeoxyribonucleaseUniRule annotation
Gene namesi
Name:DNASE1Imported
OrganismiMacaca nemestrina (Pig-tailed macaque)Imported
Taxonomic identifieri9545 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000233120 Componenti: Whole Genome Shotgun Assembly

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501441952723 – 288DeoxyribonucleaseSequence analysisAdd BLAST266

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi123 ↔ 126UniRule annotation
Disulfide bondi201 ↔ 237Essential for enzymatic activityUniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 250Endo/exonuclease/phosphataseInterPro annotationAdd BLAST205

Sequence similaritiesi

Belongs to the DNase I family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00390000013146

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR018057 Deoxyribonuclease-1_AS
IPR016202 DNase_I
IPR033125 DNASE_I_2
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
PfamiView protein in Pfam
PF03372 Exo_endo_phos, 1 hit
PIRSFiPIRSF000988 DNase_I_euk, 1 hit
PRINTSiPR00130 DNASEI
SMARTiView protein in SMART
SM00476 DNaseIc, 1 hit
SUPFAMiSSF56219 SSF56219, 1 hit
PROSITEiView protein in PROSITE
PS00919 DNASE_I_1, 1 hit
PS00918 DNASE_I_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2K6BZS3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGMRLLGAL LALLALLQGA VSLKIAAFNI QTFGETKMSN ATLVSYIVQI
60 70 80 90 100
LSRYDIALVQ EVRDSHLTAV GKLLDNLNQD APDTYHYVVS EPLGRNSYKE
110 120 130 140 150
RYLFVYRPDQ VSVVDSYYYD DGCEPCGNDT FSREPAIVRF SCPFTGSGRC
160 170 180 190 200
TEVREFAIVP LHAAPEDAVA EIDALYDVYL DVQEKWGLQD VMLMGDFNAG
210 220 230 240 250
CSYVRPSQWS SIRLRTSPTF QWLIPDTADT TATSTHCAYD RIVVAGTLLQ
260 270 280
DAVVPDSALP FNFQAAYGLS DQLAQAISDH YPVEVMLK
Length:288
Mass (Da):32,008
Last modified:March 28, 2018 - v1
Checksum:iF90EBAB560D9EB41
GO

Sequence databases

RefSeqiXP_011715932.1, XM_011717630.1

Genome annotation databases

EnsembliENSMNET00000041128; ENSMNEP00000016906; ENSMNEG00000032465
GeneIDi105467855

Similar proteinsi

Entry informationi

Entry nameiA0A2K6BZS3_MACNE
AccessioniPrimary (citable) accession number: A0A2K6BZS3
Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: September 12, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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