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Protein
Submitted name:

Laminin subunit alpha 2

Gene

LAMA2

Organism
Macaca nemestrina (Pig-tailed macaque)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Laminin subunit alpha 2Imported
Gene namesi
Name:LAMA2Imported
OrganismiMacaca nemestrina (Pig-tailed macaque)Imported
Taxonomic identifieri9545 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000233120 Componenti: Whole Genome Shotgun Assembly

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501438437523 – 3122Sequence analysisAdd BLAST3100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi309 ↔ 318PROSITE-ProRule annotation
Disulfide bondi381 ↔ 390PROSITE-ProRule annotation
Disulfide bondi414 ↔ 426PROSITE-ProRule annotation
Disulfide bondi444 ↔ 453PROSITE-ProRule annotation
Disulfide bondi488 ↔ 497PROSITE-ProRule annotation
Disulfide bondi776 ↔ 785PROSITE-ProRule annotation
Disulfide bondi835 ↔ 844PROSITE-ProRule annotation
Disulfide bondi889 ↔ 898PROSITE-ProRule annotation
Disulfide bondi901 ↔ 915PROSITE-ProRule annotation
Disulfide bondi918 ↔ 930PROSITE-ProRule annotation
Disulfide bondi920 ↔ 937PROSITE-ProRule annotation
Disulfide bondi939 ↔ 948PROSITE-ProRule annotation
Disulfide bondi967 ↔ 979PROSITE-ProRule annotation
Disulfide bondi987 ↔ 996PROSITE-ProRule annotation
Disulfide bondi1032 ↔ 1041PROSITE-ProRule annotation
Disulfide bondi1060 ↔ 1072PROSITE-ProRule annotation
Disulfide bondi1062 ↔ 1079PROSITE-ProRule annotation
Disulfide bondi1081 ↔ 1090PROSITE-ProRule annotation
Disulfide bondi1106 ↔ 1118PROSITE-ProRule annotation
Disulfide bondi1136 ↔ 1145PROSITE-ProRule annotation
Disulfide bondi1439 ↔ 1448PROSITE-ProRule annotation
Disulfide bondi1497 ↔ 1506PROSITE-ProRule annotation
Disulfide bondi1527 ↔ 1539PROSITE-ProRule annotation
Disulfide bondi1529 ↔ 1546PROSITE-ProRule annotation
Disulfide bondi1548 ↔ 1557PROSITE-ProRule annotation
Disulfide bondi2683 ↔ 2710PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 286Laminin N-terminalInterPro annotationAdd BLAST252
Domaini287 – 343Laminin EGF-likeInterPro annotationAdd BLAST57
Domaini344 – 413Laminin EGF-likeInterPro annotationAdd BLAST70
Domaini414 – 468Laminin EGF-likeInterPro annotationAdd BLAST55
Domaini469 – 517Laminin EGF-likeInterPro annotationAdd BLAST49
Domaini538 – 723Laminin IV type AInterPro annotationAdd BLAST186
Domaini757 – 806Laminin EGF-likeInterPro annotationAdd BLAST50
Domaini807 – 864Laminin EGF-likeInterPro annotationAdd BLAST58
Domaini865 – 917Laminin EGF-likeInterPro annotationAdd BLAST53
Domaini918 – 966Laminin EGF-likeInterPro annotationAdd BLAST49
Domaini967 – 1013Laminin EGF-likeInterPro annotationAdd BLAST47
Domaini1014 – 1059Laminin EGF-likeInterPro annotationAdd BLAST46
Domaini1060 – 1105Laminin EGF-likeInterPro annotationAdd BLAST46
Domaini1106 – 1165Laminin EGF-likeInterPro annotationAdd BLAST60
Domaini1180 – 1379Laminin IV type AInterPro annotationAdd BLAST200
Domaini1420 – 1468Laminin EGF-likeInterPro annotationAdd BLAST49
Domaini1469 – 1526Laminin EGF-likeInterPro annotationAdd BLAST58
Domaini1527 – 1573Laminin EGF-likeInterPro annotationAdd BLAST47
Domaini2145 – 2328LAM_G_DOMAINInterPro annotationAdd BLAST184
Domaini2340 – 2521LAM_G_DOMAINInterPro annotationAdd BLAST182
Domaini2526 – 2710LAM_G_DOMAINInterPro annotationAdd BLAST185
Domaini2763 – 2934LAM_G_DOMAINInterPro annotationAdd BLAST172
Domaini2939 – 3119LAM_G_DOMAINInterPro annotationAdd BLAST181

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1633 – 1653Sequence analysisAdd BLAST21
Coiled coili1682 – 1702Sequence analysisAdd BLAST21
Coiled coili1707 – 1757Sequence analysisAdd BLAST51
Coiled coili1765 – 1785Sequence analysisAdd BLAST21
Coiled coili1811 – 1845Sequence analysisAdd BLAST35
Coiled coili1867 – 1887Sequence analysisAdd BLAST21
Coiled coili1931 – 1955Sequence analysisAdd BLAST25
Coiled coili1981 – 2008Sequence analysisAdd BLAST28
Coiled coili2034 – 2075Sequence analysisAdd BLAST42
Coiled coili2092 – 2140Sequence analysisAdd BLAST49

Keywords - Domaini

Coiled coilSequence analysis, Laminin EGF-like domainPROSITE-ProRule annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00780000121851

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR009030 Growth_fac_rcpt_cys_sf
IPR009254 Laminin_aI
IPR010307 Laminin_dom_II
IPR002049 Laminin_EGF
IPR001791 Laminin_G
IPR000034 Laminin_IV
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
PfamiView protein in Pfam
PF00052 Laminin_B, 2 hits
PF00053 Laminin_EGF, 16 hits
PF00054 Laminin_G_1, 4 hits
PF02210 Laminin_G_2, 1 hit
PF06008 Laminin_I, 1 hit
PF06009 Laminin_II, 1 hit
PF00055 Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 7 hits
SM00180 EGF_Lam, 16 hits
SM00281 LamB, 2 hits
SM00282 LamG, 5 hits
SM00136 LamNT, 1 hit
SUPFAMiSSF49899 SSF49899, 5 hits
SSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS01248 EGF_LAM_1, 6 hits
PS50027 EGF_LAM_2, 15 hits
PS50025 LAM_G_DOMAIN, 5 hits
PS51115 LAMININ_IVA, 2 hits
PS51117 LAMININ_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2K6BZP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGAAGVLLL LLLSGGLRGG QAQRPQQQRR PQAHQQRGLF PAVLNLASNA
60 70 80 90 100
LITTNATCGE KGPEMYCKLV EHVPGQPVRN PQCRICNQNS SNPNQRHPIT
110 120 130 140 150
NAIDGKNTWW QSPSIKNGIE YHYVTITLDL QQVFQIAYVI VKAANSPRPG
160 170 180 190 200
NWILERSLDD VEYKPWQYHA VTDTECLTLY NIYPRTGPPS YAKDDEVICT
210 220 230 240 250
SFYSKIHPLE NGEIHISLIN GRPSADDPSP ELLEFTSARY IRLRFQRIRT
260 270 280 290 300
LNADLMMFAH KDPREIDPIV TRRYYYSVKD ISVGGMCICY GHARACPLDP
310 320 330 340 350
ATNKSRCECE HNTCGDSCDQ CCPGFHQKPW RAGTFLTKTE CEACNCHGKA
360 370 380 390 400
EECYYDENVA RRSLSLNIHG KYIGGGVCIN CTQNTAGINC ETCIDGFFRP
410 420 430 440 450
KGVSPNYPRP CQPCHCNPIG SLNEVCVKDE KHARRGLAPG SCHCKTGFGG
460 470 480 490 500
VSCDRCARGY TGYPDCKACN CSGLGSKNED PCFGPCNCKE NVEGGDCSRC
510 520 530 540 550
KSGFFNLQED NWKGCDECFC SGVSNRCQSS YWTYGKIQDM SGWYLTDLSG
560 570 580 590 600
RIRVAPQQDD SDSPQQISIS NAEARQALPH SYYWSAPAPY LGNKLPAVGG
610 620 630 640 650
QLTFTISYDL EEEEEDTEHV LQFMIILEGN DLRISTAQDE VYLHPSEEHV
660 670 680 690 700
NVLLLKEESF TIHGTHFPVS RKEFMTVLAN LKRVLLQITY SFGMDAIFRL
710 720 730 740 750
SSVNLESAVS YPTDGSVAAA VEVCQCPPGY TGSSCESCWP RHRRVNGTIF
760 770 780 790 800
GGICEPCQCF GHAESCDDVT GECLNCKDHT DGPYCDKCLP GFYGDPTKGT
810 820 830 840 850
SEDCQPCACP LNIPSNNFSP TCHLDRSLGL ICDGCPVGYT GPRCERCAEG
860 870 880 890 900
YFGQPSVPGG SCQPCQCNDN LDFSIPGSCD SLSGSCLICK PGTTGRYCEL
910 920 930 940 950
CADGYFGDAV DARNCQPCRC NANGSFSEIC HSQTGRCECR ANVQGQRCDK
960 970 980 990 1000
CKPGTFGLQS ARGCVPCNCN SFGSKSFDCE ENGQCWCQPG VTGKKCDRCA
1010 1020 1030 1040 1050
HGYFSFQEGG CTACECSHLG NNCDPKTGQC ICPPNTIGEK CSKCAPNTWG
1060 1070 1080 1090 1100
HSITTGCKAC NCSTVGSLDF QCNVNTGQCN CHPKFSGAKC TECSRGHWNY
1110 1120 1130 1140 1150
PRCNLCDCFL PGTDATTCDS ETKKCSCSDQ TGQCTCKVNV EGIHCDRCQP
1160 1170 1180 1190 1200
GKFGLVAKNP LGCSSCYCFG TTTQCSEAKG LIRTWVTLKA EQTILPLVDE
1210 1220 1230 1240 1250
ALQHTTTKGI VFQHPEIVAH MDLMREDLHW EPFYWKLPEQ FEGKKLMAYG
1260 1270 1280 1290 1300
GKLKYAIYFE AREETGFSTY NPQVIIRGGT PTHARIIVRH MAAPLIGQLT
1310 1320 1330 1340 1350
RHEIEMTEKE WKYYGDDPRV HRTVTREDFL DILYDIHYIL IKATYGNFMR
1360 1370 1380 1390 1400
QSRISEISME VAEQGRRTAV TPPAHLIEKC DCPLGYSGLS CEACLPGFYR
1410 1420 1430 1440 1450
LRSQPGGRTP GPTLGTCVPC QCNGHSSLCD PETSICQNCQ HHTAGDFCER
1460 1470 1480 1490 1500
CALGYYGIVK GLPNDCQQCA CPLISSSNNF SPSCVTEGLD DYRCTACPRG
1510 1520 1530 1540 1550
YEGQYCERCA PGYTGSPSSP GGSCQECECD PYGSLPVPCD PVTGICTCRP
1560 1570 1580 1590 1600
GATGRKCDGC KHWHAREGWE CVFCGDECTG LLLGDLARLE QMVMSINLTG
1610 1620 1630 1640 1650
PLPAPYKMLY GLENMTQELK HLLSPQRAPE RLIQLAEGNL NTLVTEMNEL
1660 1670 1680 1690 1700
LTRATKVTAD GEQTGQDAER TNTRAKSLGE FIKELARDAE AVNEKAIKLN
1710 1720 1730 1740 1750
ETLGTRDEAF ERNLEGLQKE IDQMIKELRR KNLETQKEIA EDELVAAEGL
1760 1770 1780 1790 1800
LKKVKKLFGE SRGKNEEMEK DLREKLADYK NKVDDAWDLL REATNKIREA
1810 1820 1830 1840 1850
NRLFAVNQKN MTALEKKKEA VESGKRQIEN TLKEGNDILD EANRLADEIN
1860 1870 1880 1890 1900
SIIDYVEDIQ TKLPPMSEEL NNKIDDLSQE IKDRKLAEKV SQAESHAAQL
1910 1920 1930 1940 1950
NDSSAVLDGI LDEAKNISFN ATAAFKAYSN IKDYIDEAEK VAKEAKDLAH
1960 1970 1980 1990 2000
EATKLATGPR GLLKEDAKGS LQKSFRILNE AKKLANDVKE NEDHLNGLKT
2010 2020 2030 2040 2050
RIENADARNG DLLRALNDTL GKLSAIPNDT AAKLQAVKDK ARQANDTAKD
2060 2070 2080 2090 2100
VLAQIKELHQ NLDGLKKNYD KLADSVAKTN AVVKDPSKNK IIAHADATVK
2110 2120 2130 2140 2150
NLEQEADRLI DKLKPIKELE DNLKKNISEI KELINQARKQ ANSIKVSVSS
2160 2170 2180 2190 2200
GGDCIRTYKP EIKKGSYNNI VVNVKTAVAD NLLFYLGSAK FIDFLAIEMR
2210 2220 2230 2240 2250
KGKVSFLWDV GSGVGRVEYP DLTIDDSYWY RIMASRTGRN GTISVRALDG
2260 2270 2280 2290 2300
PKASIVPSTY HSTSPPGYTI LDVDANAMLF VGGLTGKLKK ADAVRVITFT
2310 2320 2330 2340 2350
GCMGETYFDN KPIGLWNFRE KEGDCKGCTV SPQVEDSEGT IQFDGEGYAL
2360 2370 2380 2390 2400
VSRPIRWYPN ISTVMFKFRT FSSSALLMYL ATRDLRDFMS VELTDGHIKV
2410 2420 2430 2440 2450
SYDLGSGMAS VVSNQNHNDG KWKSFTLSRI QKQANISIVD IDTNQEENIA
2460 2470 2480 2490 2500
TSSSGNNFGL DLKADDKIYF GGLPTLRNLS MKARPEVNLK KYSGCLKDIE
2510 2520 2530 2540 2550
ISRTPYNILS SPDYVGVTKG CSLENVYTVS FPKPGFVELS PVPIDVGTEI
2560 2570 2580 2590 2600
NLSFSTKNES GIILLGSGGT PAPPRRKRRQ TGQAYYAILL NRGRLEVHLS
2610 2620 2630 2640 2650
TGARTMRKIV VRPEPNLFHD GREHSVHVER TRGIFTVQVD ENRRYMQNLT
2660 2670 2680 2690 2700
VEQPLEVKKL FVGGAPPEFQ PSPLRNIPPF EGCVWNLVIN SVPMDFARPV
2710 2720 2730 2740 2750
SFKNADIGRC VHQKLHEDED GAAPAEIVIQ PEPVPTPAFP TPTPVLTHGP
2760 2770 2780 2790 2800
CAAESEPDLL MGSKQFGLSR NSHIAIAFDD TKVKNRLTIE LEVRTEAESG
2810 2820 2830 2840 2850
LLFYMARINH ADFATVQLRN GLPYFSYDLG SGDTNTMIPT KINDGQWHKI
2860 2870 2880 2890 2900
KIMRSKQEGI LYVDGASNRT ISPRKADILD VVGMLYVGGL PINYTTRRIG
2910 2920 2930 2940 2950
PVTYSIDGCI RNLHMAEAPA DLEEPTSSFH IGTCFANAQR GTYFDGTGFA
2960 2970 2980 2990 3000
KAVGGFKVGL DLLVEFEFRT TRTTGVLLGI SSQKMDGMGI EMIDEKLMFH
3010 3020 3030 3040 3050
VDNGAGRFTA VYDAGVPGHL CDGQWHKVTA NKIKHRIELT VDGNQVEAQS
3060 3070 3080 3090 3100
LNPASTSADT NDPVFVGGFP DDLKQFGLTT SIPFRGCVRS LKLTKGTGKP
3110 3120
LEVNFAKALE LRGVQPVSCP AN
Length:3,122
Mass (Da):344,365
Last modified:March 28, 2018 - v1
Checksum:i2C97C04419F5299F
GO

Sequence databases

RefSeqiXP_011712392.1, XM_011714090.1

Genome annotation databases

EnsembliENSMNET00000041085; ENSMNEP00000016865; ENSMNEG00000032185
GeneIDi105465590

Similar proteinsi

Entry informationi

Entry nameiA0A2K6BZP0_MACNE
AccessioniPrimary (citable) accession number: A0A2K6BZP0
Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: July 18, 2018
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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