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UniProtKB - A0A2K6BN16 (A0A2K6BN16_MACNE)

Entry version 16 (10 Feb 2021)
Sequence version 1 (28 Mar 2018)
Previous versions | rss
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Protein
Submitted name:

Uncharacterized protein

Gene

AFDN

Organism
Macaca nemestrina (Pig-tailed macaque)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesionARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AFDNImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacaca nemestrina (Pig-tailed macaque)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9545 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000233120 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini58 – 153Ras-associatingInterPro annotationAdd BLAST96
Domaini266 – 368Ras-associatingInterPro annotationAdd BLAST103
Domaini673 – 920DiluteInterPro annotationAdd BLAST248
Domaini1019 – 1105PDZInterPro annotationAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni148 – 214DisorderedSequence analysisAdd BLAST67
Regioni369 – 398DisorderedSequence analysisAdd BLAST30
Regioni544 – 600DisorderedSequence analysisAdd BLAST57
Regioni1119 – 1202DisorderedSequence analysisAdd BLAST84
Regioni1214 – 1235DisorderedSequence analysisAdd BLAST22
Regioni1247 – 1540DisorderedSequence analysisAdd BLAST294
Regioni1581 – 1836DisorderedSequence analysisAdd BLAST256

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi163 – 214PolyampholyteSequence analysisAdd BLAST52
Compositional biasi369 – 389PolyampholyteSequence analysisAdd BLAST21
Compositional biasi549 – 573PolarSequence analysisAdd BLAST25
Compositional biasi1142 – 1157PolarSequence analysisAdd BLAST16
Compositional biasi1166 – 1181PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1182 – 1202PolarSequence analysisAdd BLAST21
Compositional biasi1286 – 1312PolyampholyteSequence analysisAdd BLAST27
Compositional biasi1314 – 1352PolarSequence analysisAdd BLAST39
Compositional biasi1372 – 1387Pro-richSequence analysisAdd BLAST16
Compositional biasi1418 – 1454PolyampholyteSequence analysisAdd BLAST37
Compositional biasi1455 – 1504PolarSequence analysisAdd BLAST50
Compositional biasi1526 – 1540PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1602 – 1688PolyampholyteSequence analysisAdd BLAST87
Compositional biasi1694 – 1723Pro-richSequence analysisAdd BLAST30
Compositional biasi1774 – 1788PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1805 – 1820PolarSequence analysisAdd BLAST16
Compositional biasi1821 – 1836PolyampholyteSequence analysisAdd BLAST16

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155237

Family and domain databases

Conserved Domains Database

More...CDDi		cd00060, FHA, 1 hit
cd15471, Myo5p-like_CBD_afadin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037977, CBD_Afadin
IPR002710, Dilute_dom
IPR000253, FHA_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000159, RA_dom
IPR008984, SMAD_FHA_dom_sf
IPR029071, Ubiquitin-like_domsf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01843, DIL, 1 hit
PF00498, FHA, 1 hit
PF00595, PDZ, 1 hit
PF00788, RA, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01132, DIL, 1 hit
SM00240, FHA, 1 hit
SM00228, PDZ, 1 hit
SM00314, RA, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49879, SSF49879, 1 hit
SSF50156, SSF50156, 1 hit
SSF54236, SSF54236, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51126, DILUTE, 1 hit
PS50106, PDZ, 1 hit
PS50200, RA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A2K6BN16-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQAGNRTPP RKGVPSPPLG LRGGALCGGL CPEGGAGPVL APREEEEITL 
        60         70         80         90        100
SPGLDLEFHG VMRFYFQDKA AGNFATKCIR VSSTATTQDV IETLAEKFRP 
       110        120        130        140        150
DMRMLSSPKY SLYEVHVSGE ERRLDIDEKP LVVQLNWNKD DREGRFVLKN 
       160        170        180        190        200
ENDAIPPKKA QSNGPEKQEK EGVIQNFKRT LSKKEKKEKK KREKEALRQA 
       210        220        230        240        250
SDKDDRPFQG EDVENSRLAA EVYKDMPETS FTRTISNPEV VMKRRRQQKL 
       260        270        280        290        300
EKRMQEFRSS DGRPDSGGTL RIYADSLKPN IPYKTILLST TDPADFAVAE 
       310        320        330        340        350
ALEKYGLEKE NPKDYCIARV MLPPGAQHSD EKGAKEIILD DDECPLQIFR 
       360        370        380        390        400
EWPSDKGILV FQLKRRPPDH IPKKTKKHLE GKTPKGKERA DGSGYGSALP 
       410        420        430        440        450
PEKLPYLVEL SPDGSDSRDK PKLYRLQLSV TEVGTEKLDD SSIQLFGPGI 
       460        470        480        490        500
QPHHCDLTNM DGVVTVTPRS MDAETYVEGQ RISETTMLQS GMKVQFGASH 
       510        520        530        540        550
VFKFVDPSQD HALAKRSVDG GLMVKGPRHK PGIVQETTFD LGGDIHSGTA 
       560        570        580        590        600
LPTSKSTTRL DSDRVSSASS TAERGMVKPM IRVEQQPDYR RQESRTQDAS 
       610        620        630        640        650
GPELILPASI EFRESSEDSF LSAIINYTNS STVHFKLSPT YVLYMACRYV 
       660        670        680        690        700
LSNQYRPDIS PTERTHKVIA VVNKMVSMME GVIQEVDQVD QKQKNIAGAL 
       710        720        730        740        750
AFWMANASEL LNFIKQDRDL SRITLDAQDV LAHLVQMAFK YLVHCLQSEL 
       760        770        780        790        800
NNYMPAFLDD PEENSLQRPK IDDVLHTLTG AMSLLRRCRV NAALTIQLFS 
       810        820        830        840        850
QLFHFINMWL FNRLVTDPDS GLCSHYWGAI IRQQLGHIEA WAEKQGLELA 
       860        870        880        890        900
ADCHLSRIVQ ATTLLTMDKY APDDIPNINS TCFKLNSLQL QALLQNYHCA 
       910        920        930        940        950
PDEPFIPTDL IENVVAVAEN TADELARSDG REVQLEEDPD LQLPFLLPED 
       960        970        980        990       1000
GYSCDVVRNI PNGLQEFLDP LCQRGFCRLI PHTRSPGTWT IYFEGADYES 
      1010       1020       1030       1040       1050
HLLRENTELA QPLRKEPEII TVTLKKQNGM GLSIVAAKGA GQDKLGIYVK 
      1060       1070       1080       1090       1100
SVVKGGAADV DGRLAAGDQL LSVDGRSLVG LSQERAAELM TRTSSVVTLE 
      1110       1120       1130       1140       1150
VAKQGAIYHG LATLLNQPSP MMQRISDRRG SGKPRPKSEG FELYNNSAQN 
      1160       1170       1180       1190       1200
GSPESPQLPW AEYSEPKKLP GDDRLTKNRA DHRSSPNVAN QPPSPGGKSA 
      1210       1220       1230       1240       1250
YASGTAAKIT SVSTGNLCTE EQTPPPRPEA YPIPTQTYTR EYFTFPASKS 
      1260       1270       1280       1290       1300
QDRMAPPQNQ WPNYEEKPHM HTDSNHSSIA IQRVTRSQEE LREDKAYQLE 
      1310       1320       1330       1340       1350
RHRIEAAMDR KSDSDMWINQ SSSLDSSTSS QEHLNHSSKS VTPASTLTKS 
      1360       1370       1380       1390       1400
GPGRWKTPAA IPATPVAVSQ PIRTDLPPPP PPPPVHYAGD FDGMSMDLPL 
      1410       1420       1430       1440       1450
PPPPSTNQIG LPSAQVAAAE RKKREEHQRW YEKEKARLEE ERERKRREQE 
      1460       1470       1480       1490       1500
RKLGQMRTQS LNPAPFSPLT TQQMKPEKPS TLQRPQETVI RELQPQQQPR 
      1510       1520       1530       1540       1550
TIERRDLQYI TVSKEELSSG DSLSPDPWKR DAKEKLEKQQ QMHIVDMLSK 
      1560       1570       1580       1590       1600
EIQELQSKPD RSAEESDRLR KLMLEWQFQK RLQESKQKDE DDEEEEDDDV 
      1610       1620       1630       1640       1650
DTMLIMQRLE AERRARLQDE ERRRQQQLEE MRKREAEDRA RQEEERRRQE 
      1660       1670       1680       1690       1700
EERTKRDAEE KRRQEEGYYS RLEAERRRQH DEAARRLLEP EAPGLCRPPL 
      1710       1720       1730       1740       1750
PRDYEPPSPS PAPGAPPPPP QRNASYLKTQ VLSPDSLFTA KFVAYNEEEE 
      1760       1770       1780       1790       1800
EEDCSLAGPN SYPGSAGAAV GAHDAYRDAK EKRSKSQDAD LPGSSGAPEN 
      1810       1820       1830 
LTFKERQRLF SQGQDVSNKV KASRKLTELE NELNTK
Length:1,836
Mass (Da):206,912
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF0836AD42E68164
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K6BN46A0A2K6BN46_MACNE
Uncharacterized protein
AFDN
1,781Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K6BN02A0A2K6BN02_MACNE
Uncharacterized protein
AFDN
1,799Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K6BN94A0A2K6BN94_MACNE
Uncharacterized protein
AFDN
1,796Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMNET00000036968; ENSMNEP00000012770; ENSMNEG00000030609

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSMNET00000036968; ENSMNEP00000012770; ENSMNEG00000030609

Phylogenomic databases

GeneTreeiENSGT00940000155237

Family and domain databases

CDDicd00060, FHA, 1 hit
cd15471, Myo5p-like_CBD_afadin, 1 hit
Gene3Di2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR037977, CBD_Afadin
IPR002710, Dilute_dom
IPR000253, FHA_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000159, RA_dom
IPR008984, SMAD_FHA_dom_sf
IPR029071, Ubiquitin-like_domsf
PfamiView protein in Pfam
PF01843, DIL, 1 hit
PF00498, FHA, 1 hit
PF00595, PDZ, 1 hit
PF00788, RA, 2 hits
SMARTiView protein in SMART
SM01132, DIL, 1 hit
SM00240, FHA, 1 hit
SM00228, PDZ, 1 hit
SM00314, RA, 2 hits
SUPFAMiSSF49879, SSF49879, 1 hit
SSF50156, SSF50156, 1 hit
SSF54236, SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS51126, DILUTE, 1 hit
PS50106, PDZ, 1 hit
PS50200, RA, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K6BN16_MACNE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K6BN16
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: February 10, 2021
This is version 16 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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