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Entry version 16 (07 Apr 2021)
Sequence version 1 (28 Mar 2018)
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Protein
Submitted name:

Uncharacterized protein

Gene

TSPOAP1

Organism
Macaca nemestrina (Pig-tailed macaque)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TSPOAP1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacaca nemestrina (Pig-tailed macaque)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9545 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000233120 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini651 – 718SH3InterPro annotationAdd BLAST68
Domaini882 – 974Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini979 – 1079Fibronectin type-IIIInterPro annotationAdd BLAST101
Domaini1619 – 1687SH3InterPro annotationAdd BLAST69
Domaini1758 – 1826SH3InterPro annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 105DisorderedSequence analysisAdd BLAST105
Regioni279 – 321DisorderedSequence analysisAdd BLAST43
Regioni334 – 363DisorderedSequence analysisAdd BLAST30
Regioni559 – 627DisorderedSequence analysisAdd BLAST69
Regioni727 – 785DisorderedSequence analysisAdd BLAST59
Regioni1081 – 1234DisorderedSequence analysisAdd BLAST154
Regioni1246 – 1302DisorderedSequence analysisAdd BLAST57
Regioni1322 – 1473DisorderedSequence analysisAdd BLAST152
Regioni1495 – 1604DisorderedSequence analysisAdd BLAST110
Regioni1717 – 1750DisorderedSequence analysisAdd BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili123 – 150Sequence analysisAdd BLAST28
Coiled coili159 – 193Sequence analysisAdd BLAST35
Coiled coili224 – 251Sequence analysisAdd BLAST28
Coiled coili417 – 482Sequence analysisAdd BLAST66
Coiled coili492 – 519Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi288 – 305Pro-richSequence analysisAdd BLAST18
Compositional biasi598 – 621PolarSequence analysisAdd BLAST24
Compositional biasi737 – 761PolarSequence analysisAdd BLAST25
Compositional biasi1110 – 1133Pro-richSequence analysisAdd BLAST24
Compositional biasi1162 – 1176PolarSequence analysisAdd BLAST15
Compositional biasi1203 – 1217PolarSequence analysisAdd BLAST15
Compositional biasi1273 – 1290PolarSequence analysisAdd BLAST18
Compositional biasi1405 – 1421PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1535 – 1549Pro-richSequence analysisAdd BLAST15
Compositional biasi1550 – 1589PolyampholyteSequence analysisAdd BLAST40

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RIMBP family.ARBA annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183203

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063, FN3, 1 hit
cd12012, SH3_RIM-BP_2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR035753, RIM-BP_SH3_2
IPR040325, RIMBP1/2/3
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR14234, PTHR14234, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07653, SH3_2, 2 hits
PF14604, SH3_9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060, FN3, 3 hits
SM00326, SH3, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265, SSF49265, 2 hits
SSF50044, SSF50044, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853, FN3, 2 hits
PS50002, SH3, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A2K6BCD1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQLTTLPRP GNPGAMEPWA LPTWQSWTPG RGGEPGDAVP SVADTPPAAL
60 70 80 90 100
QLPELRSEES SEPKGARSSG PIGGTDPEEA EACLPSLGQQ ASSSGPACQR
110 120 130 140 150
PEDEEVEAFP KAKLNMGFGD RPNLELLRAL GELRQRCAIL KEENQMLRKS
160 170 180 190 200
SFPETEEKVR RLKRKNAELA VIAKRLEERA RKLQETNLRV VSAPLPRPGA
210 220 230 240 250
SLELCRKALA RQRARDLSET ASALLAKDKQ IAALQRECRE LQARLTLVGK
260 270 280 290 300
EGPQWLHVRD FDRLLRESQR EVLRLQRQIA LRNQRETPPR PPSRPPGPAL
310 320 330 340 350
PARAEAPAPG APGEATPQED ADNLPVILGE PEKEQRVQQL ESELSKKRKK
360 370 380 390 400
CESLEQEARK KQRRCEELEL QLREAQNENA RLVEENSRLS GRVTEKEQVE
410 420 430 440 450
WENAELRGQL LGVTQERDSA LRKSQGLQSK LESLEQVLKH MREVAQRRQQ
460 470 480 490 500
LEVEHEQARL SLREKQEEVR RLQQAQAEAK KEHEGAVQLL EVGRLEARVR
510 520 530 540 550
ELEEQCRSQT EQFSLLAQEL QAFRLHPGPL DLLTSALDCG TLGDRPPPPC
560 570 580 590 600
CCSTPRPCRG SGPKDLDLPP GSPGRCTPKS SEPAPATLTG VPRRTAKKAE
610 620 630 640 650
SLSNSSHSES IHNSPKSCPT PEVDTASEVE ELEVDSVSLL PATPEGSRGG
660 670 680 690 700
ARIQVFLARY SYNPFEGPNE NPEAELPLTA GEYIYVYGNM DEDGFFEGEL
710 720 730 740 750
MDGRRGLVPS NFVERVSDDD LLTSLPPELA DLSHSSGPEL SFLSVGGGGS
760 770 780 790 800
SSGGQSSGGR SQPRPEEEDA GDDLSVSPSP EGLGEPPAVP YPRCLVVLKQ
810 820 830 840 850
LAHSVVLAWE PPPERVELHG FHICVNGELR QALGPGAPPK AVLENLDLRA
860 870 880 890 900
GPLHISVQAL TSRGSSDPLR CCLAVGARAG VVPSQLRVHR LTATSAEITW
910 920 930 940 950
VPGNSNLAHA IYLNGEECPP ASPSTYWATF CHLRPGTPYQ AQVEAQLPPQ
960 970 980 990 1000
GPWEPGWERL EQRAATLQFT TLPAGPPDAP LDVQIEPGPS PGILIISWLP
1010 1020 1030 1040 1050
VTIDAAGTSN GVRVTGYAIY ADGQKIMEVA SPTAGSVLVE LSQLQLLQVC
1060 1070 1080 1090 1100
REVVVRTMSP HGESADSIPA PITPALAPAS LPARVSCPSP RPSPEARAPL
1110 1120 1130 1140 1150
ASASPAPGDP SSPLQHPAPL GTQEPPGAPP ASPSREMPKG SHEDPPAPCS
1160 1170 1180 1190 1200
QEEAGAAVLG TSEERTASTS TLGEKDPSPA APSLAKQEAE WTAGEACPAP
1210 1220 1230 1240 1250
SSAQGALAQQ APNTEACQGG DPGSGLRPRA EKEDAAELGV HLVNSLVDHG
1260 1270 1280 1290 1300
RNSDLSDIQE EEEEEEEELG SRTCSFQKQV AGNSIRENGA KSQPDPFCET
1310 1320 1330 1340 1350
DSDEEILEQI LELPLQQFCS KKLFSIPEEE EEEEEDEEKE KPGAGCSSQD
1360 1370 1380 1390 1400
PGPPEPALLG LGCDSGQPRR PGQCPLSPEP SRAGDCLEDM PGLVGGSSRR
1410 1420 1430 1440 1450
RGGGSPEKPP SRRRPPDPRE HCSRLLSNNG PQASGRPGPT RERGGLPVIE
1460 1470 1480 1490 1500
GPRTGLEASG RGRLGPSRRC SRGRALEPGL ASCLSPKCLE ISIEYDSEDE
1510 1520 1530 1540 1550
QEAGSGGISI TSSCYPGDGE AWVTATVGRP RGPPKANSGP KPYPPLPAWE
1560 1570 1580 1590 1600
KGEPERRGRS ATGRAKEPLS RATETREARG QDSSGRRGPQ KRGARVPRPS
1610 1620 1630 1640 1650
TAELVPVRSP SEALAYQHLP VRIFVALFDY DPVSMSPNPD AGEEELPFRE
1660 1670 1680 1690 1700
GQILKVFGDK DADGFYRGEG GGRTGYIPCN MVAEVAVDSP AGRQQLLQRG
1710 1720 1730 1740 1750
YLSPDILLEG SGNGPFVYST ARTTGPPPKP RRSKKAESEG PAQPCPGPPK
1760 1770 1780 1790 1800
LVPSAELKAP HSMVAAFDYN PQESSPNMDV EAELPFRAGD VITVFGGMDD
1810 1820 1830 1840 1850
DGFYYVRTLM GRVYHTPAPQ TSQGGLSQSW AGGWARNPQE VWWNGTGHLP
1860
GQWFWPQLFP RGIRVEGQS
Length:1,869
Mass (Da):201,514
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i738F56F1F2509CE1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K6BCE1A0A2K6BCE1_MACNE
Uncharacterized protein
TSPOAP1
1,793Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K6BCG2A0A2K6BCG2_MACNE
Uncharacterized protein
TSPOAP1
1,853Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K6BCE5A0A2K6BCE5_MACNE
Uncharacterized protein
TSPOAP1
828Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMNET00000033259; ENSMNEP00000009088; ENSMNEG00000028963

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSMNET00000033259; ENSMNEP00000009088; ENSMNEG00000028963

Phylogenomic databases

GeneTreeiENSGT00950000183203

Family and domain databases

CDDicd00063, FN3, 1 hit
cd12012, SH3_RIM-BP_2, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR035753, RIM-BP_SH3_2
IPR040325, RIMBP1/2/3
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PANTHERiPTHR14234, PTHR14234, 1 hit
PfamiView protein in Pfam
PF07653, SH3_2, 2 hits
PF14604, SH3_9, 1 hit
SMARTiView protein in SMART
SM00060, FN3, 3 hits
SM00326, SH3, 3 hits
SUPFAMiSSF49265, SSF49265, 2 hits
SSF50044, SSF50044, 3 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 2 hits
PS50002, SH3, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K6BCD1_MACNE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K6BCD1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: April 7, 2021
This is version 16 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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