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Entry version 7 (10 Apr 2019)
Sequence version 1 (28 Mar 2018)
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Protein
Submitted name:

Uncharacterized protein

Gene

TOPBP1

Organism
Macaca nemestrina (Pig-tailed macaque)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TOPBP1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacaca nemestrina (Pig-tailed macaque)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9545 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000233120 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Whole Genome Shotgun Assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini196 – 267BRCTInterPro annotationAdd BLAST72
Domaini290 – 379BRCTInterPro annotationAdd BLAST90
Domaini449 – 539BRCTInterPro annotationAdd BLAST91
Domaini648 – 733BRCTInterPro annotationAdd BLAST86
Domaini741 – 838BRCTInterPro annotationAdd BLAST98
Domaini1000 – 1091BRCTInterPro annotationAdd BLAST92
Domaini1359 – 1451BRCTInterPro annotationAdd BLAST93

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157001

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00027 BRCT, 6 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10190, 9 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR035960 Secretoglobin_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00533 BRCT, 4 hits
PF12738 PTCB-BRCT, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00292 BRCT, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48201 SSF48201, 1 hit
SSF52113 SSF52113, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50172 BRCT, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A2K6B637-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRSPPLLTF PLSCRSCGWR HFHRKRRAQP RGWRESRFPF WSISGFSSVC
60 70 80 90 100
FGVGAAPSRG RGLCAGLAPD PSHRPAGSAS PDSPPGDPEA PTSSEMSRND
110 120 130 140 150
KEPFFVKFLK SSDNSKCFFK ALESIKEFQS EEYLQIITEE EALKIKENDR
160 170 180 190 200
SLYICDPFSG IVFDHLKKLG CRIVGPQVVI FCMHHQRCVP RAEHPVYNMV
210 220 230 240 250
MSDVTVSCTS LEKEKREEVH KYVQMMGGRV YRDLNVSVTH LIAGEVGSKK
260 270 280 290 300
YLVAANLKKP ILLPSWIKTL WEKSQEKKIT RYTDINMEDF KCPIFLGCII
310 320 330 340 350
CVTGLCGLDR KEVQQLTVKH GGQYMGQLKM NECTHLIVQE PKGQKYECAK
360 370 380 390 400
RWNVHCVTTQ WFFDSIEKGF CQDESMYKTE PRPEAKTMPN SSTPTGQINT
410 420 430 440 450
IDSRTLSDVS NISNINASCI SESICNSLNS KLEPTLENLE NLDVSAFQAP
460 470 480 490 500
EDLLDGCRIY LCGFSGRKLD KLRRLINSGG GVRFNQLNED VTHVIVGDYD
510 520 530 540 550
DELKQFWNKS AHRPHVVGAK WLLECFSKGY MLSEEPYIHA NYQPVEIPVS
560 570 580 590 600
DQPESKAALL KKKNSSFSKK DFAPSEKREQ ADEDLLSQYE NDSSTVVEAK
610 620 630 640 650
TSEAEKSEVR PFNNSTRAEP LNDSTHVSLQ EENQSSVSHC VPDVSTITEE
660 670 680 690 700
GLFSQKSFLV LGFSNENESN IASIIKENAG KIMSLLSRTV ADYAVVPLLG
710 720 730 740 750
CEVEATVGEV VTNTWLVTCI DFQTLFDPKS NPLFTPVPVM TGMTPLEDCV
760 770 780 790 800
ISFSQCAGAE KESLTFLANL LGASVQEYFV RKSNAKKGMF ASTHLILKEP
810 820 830 840 850
GGSKYEAAKK WNLPAVTIAW LLETARTGKR ADESHFLIEN SSEEERSLET
860 870 880 890 900
EITNGINLNS DTAEHPGTRL QTHRKTVITP LDMNRFQSKA FRAVVSQHAR
910 920 930 940 950
QVSASPAVGQ PLQKEPSLHL DTPSKFLSKD KLFKPSFDVK DALAALETPG
960 970 980 990 1000
RPSQQKRKLS TPLSEVIVKN LQLALANSSR NAVALSASPQ LKEAQSEKEE
1010 1020 1030 1040 1050
APKPLHRVVV CVSKKLSKKQ SELNGIAASL GADYRWSFDE TVTHFIYQGR
1060 1070 1080 1090 1100
PNDTNREYKS VKERGVHIVS EHWLLDCAQE YKHLPESLYP HTYNPKMSLD
1110 1120 1130 1140 1150
ISAVQDGRLC NSRLLSAVSA TKDDEPDPLI LEENDVDNMA TNNNESAPSN
1160 1170 1180 1190 1200
GNGKNDSKGV LTQTLEMREN FQKQLQEIMS ATSIVKPQGQ RTSLSRSGCN
1210 1220 1230 1240 1250
SASSTPDSTR SARSGRSRVL EALRQSRQTV PDVNTEPSQN EQIIWDDPTA
1260 1270 1280 1290 1300
REERARLASN LQWPSCPTQY SELQVDIQNL EDSPFQKPLR DSEIAKQAVC
1310 1320 1330 1340 1350
DPGDIRVTEA PKHPISEELE TPIKDSHLIP TPQAPSIAFP LANPPVAPHP
1360 1370 1380 1390 1400
REKIITIEET HEELKKQYIF QLSSLNPQER IDYCHLIEKL GGLVIEKQCF
1410 1420 1430 1440 1450
DPSCTHIVVG HPLRNEKYLA SVAAGKWVLH RSYLEACRTA GHFVQEEDYE
1460 1470 1480 1490 1500
WGSSSILDVL TGINVQQRRL ALAAMRWRKK IQQRQESGIV EGAFSGWKVI
1510 1520 1530 1540 1550
LHVDQSREAG FKRLLQSGGA KVLPGHSVPL FKEATHLFSD LNKLKPDDSG
1560 1570 1580 1590 1600
VNITEAAAQN VYCLRTEYIA DYLMQESPPH VENYCLPEAI SFLQNNKELG
1610 1620
TGLSQKRKAS TEKNKMKRPR VH
Length:1,622
Mass (Da):181,632
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4B0B172C5EFF73F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K6B662A0A2K6B662_MACNE
Uncharacterized protein
TOPBP1
1,528Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMNET00000031003; ENSMNEP00000006873; ENSMNEG00000027744

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMNET00000031003; ENSMNEP00000006873; ENSMNEG00000027744

Phylogenomic databases

GeneTreeiENSGT00940000157001

Family and domain databases

CDDicd00027 BRCT, 6 hits
Gene3Di3.40.50.10190, 9 hits
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR035960 Secretoglobin_sf
PfamiView protein in Pfam
PF00533 BRCT, 4 hits
PF12738 PTCB-BRCT, 2 hits
SMARTiView protein in SMART
SM00292 BRCT, 7 hits
SUPFAMiSSF48201 SSF48201, 1 hit
SSF52113 SSF52113, 6 hits
PROSITEiView protein in PROSITE
PS50172 BRCT, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K6B637_MACNE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K6B637
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: April 10, 2019
This is version 7 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
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