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Protein
Submitted name:

Adenylate cyclase 9

Gene

ADCY9

Organism
Macaca nemestrina (Pig-tailed macaque)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotation
LigandNucleotide-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Adenylate cyclase 9Imported
Gene namesi
Name:ADCY9Imported
OrganismiMacaca nemestrina (Pig-tailed macaque)Imported
Taxonomic identifieri9545 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000233120 Componenti: Whole Genome Shotgun Assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Transmembranei142 – 164HelicalSequence analysisAdd BLAST23
Transmembranei176 – 198HelicalSequence analysisAdd BLAST23
Transmembranei242 – 261HelicalSequence analysisAdd BLAST20
Transmembranei788 – 809HelicalSequence analysisAdd BLAST22
Transmembranei821 – 843HelicalSequence analysisAdd BLAST23
Transmembranei855 – 880HelicalSequence analysisAdd BLAST26
Transmembranei892 – 910HelicalSequence analysisAdd BLAST19
Transmembranei977 – 996HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini394 – 521Guanylate cyclaseInterPro annotationAdd BLAST128
Domaini1058 – 1198Guanylate cyclaseInterPro annotationAdd BLAST141

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000119042

Family and domain databases

Gene3Di3.30.70.1230, 2 hits
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF00211 Guanylate_cyc, 2 hits
SMARTiView protein in SMART
SM00044 CYCc, 2 hits
SUPFAMiSSF55073 SSF55073, 2 hits
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 2 hits
PS50125 GUANYLATE_CYCLASE_2, 2 hits

Sequencei

Sequence statusi: Complete.

A0A2K6AX62-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPPHQQLL HHHSTEVSCD SSGDSNSVRV KINPKQLSSN SHPKHCKYSI
60 70 80 90 100
SSSCSSSGDS GGVPRRVGGG GRLRRQKKLP QLFERASSRW WDPKFDSVNL
110 120 130 140 150
EEACLERCFP QTQRRFRYAL FYIGFACLLW SIYFAVHMRS RLIVMVAPAL
160 170 180 190 200
CFLVVCVGFF LFTFTKLYAR HYARTSLALT LLVFALTLAA QFQVLTPVSG
210 220 230 240 250
RGDSSNLTAT AQPTDTCLSQ VGSFSMCIEV LFLLYTVMHL PLYLSLCLGV
260 270 280 290 300
AYSVLFETFG YHFRDEACFP SPGAGALHWE LLSRALLHGC IHAIGVHLFI
310 320 330 340 350
MSQVRSRSTF LKVGQSIMHG KDLEVEKALK ERMIHSVMPR IIADDLMKQG
360 370 380 390 400
DEESENSVKR HATSSPKNRK KKSSIQKAPI AFRPFKMQQI EEVSILFADI
410 420 430 440 450
VGFTKMSANK SAHALVGLLN DLFGRFDRLC EETKCEKIST LGDCYYCVAG
460 470 480 490 500
CPEPRADHAY CCIEMGLGMI KAIEQFCQEK KEMVNMRVGV HTGTVLCGIL
510 520 530 540 550
GMRRFKFDVW SNDVNLANLM EQLGVAGKVH ISEATAKYLD DRYEMEDGKV
560 570 580 590 600
IERLGHSVVA DQLKGLKTYL ISGQRAKESR CSCAEALLSG FEIIDGSQVS
610 620 630 640 650
SGPRGQGTAS SGNVSDLAQT VKTFDNLKTC PSCGITFAPK SEAGAEGGAP
660 670 680 690 700
QNGCQDEHKN STKASGGPNP KTQNGLLSPP QEEKLTNSQT SLCEILQEKG
710 720 730 740 750
RWAGVSLDQS ALLPLRFKNI REKTDAHFVD VIKEDSLMKD YFFKPPINQF
760 770 780 790 800
SLNFLDQELE RSYRTSYQEE VIKNSPVKTF ASPTFSSLLD VFLSTIVFLM
810 820 830 840 850
LSTTCFLKYE AATTPPPPAA LAVFSAALLL EVLSLAVSIR MVFFLEDVMA
860 870 880 890 900
CTKRLLEWIA GWLPRHCIGA ILVSLPALAV YSHVTSEFET NIHFPVFTGS
910 920 930 940 950
AALIAVVHYC NFCQLSSWMR SSLATVVGAG PLLLLYVSLC PDSSVLTSPL
960 970 980 990 1000
DAVQNFSSER NPCNSSVPRD LRRPASLIGQ EVVLVFFLLL LLVWFLNREF
1010 1020 1030 1040 1050
EVSYRLHYHG DVEADLHRTK IQSMRDQADW LLRNIIPYHV AEQLKVSQTY
1060 1070 1080 1090 1100
SKNHDSGGVI FASIVNFSEF YEENYEGGKE CYRVLNELIG DFDELLSKPD
1110 1120 1130 1140 1150
YSSIEKIKTI GATYMAASGL NTAQAQDGSH PQEHLQILFE FAKEMMRVVD
1160 1170 1180 1190 1200
DFNSNMLWFN FKLRVGFNHG PLTAGVIGTT KLLYDIWGDT VNIASRMDTT
1210 1220 1230 1240 1250
GVECRIQVSE ESYRVLSKMG YDFDYRGTVN VKGKGQMKTY LYPKCTDHGV
1260 1270 1280 1290 1300
FPQHQLSISP DIRVQVDGSI GRSPTDEIAN LVPSVQYVDK TSLGSESSTQ
1310 1320 1330 1340 1350
AKDAHLSPKR PWKEPVKAEE RGRFGRAIEK DDCDETGVEE ANELTKLNVS

KSV
Length:1,353
Mass (Da):150,644
Last modified:March 28, 2018 - v1
Checksum:i6B595A0E6602CC57
GO

Sequence databases

RefSeqiXP_011715921.1, XM_011717619.1
XP_011715922.1, XM_011717620.1

Genome annotation databases

EnsembliENSMNET00000019125; ENSMNEP00000003749; ENSMNEG00000017512
ENSMNET00000019137; ENSMNEP00000003752; ENSMNEG00000017512
GeneIDi105467851

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_011715921.1, XM_011717619.1
XP_011715922.1, XM_011717620.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMNET00000019125; ENSMNEP00000003749; ENSMNEG00000017512
ENSMNET00000019137; ENSMNEP00000003752; ENSMNEG00000017512
GeneIDi105467851

Organism-specific databases

CTDi115

Phylogenomic databases

GeneTreeiENSGT00760000119042

Family and domain databases

Gene3Di3.30.70.1230, 2 hits
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF00211 Guanylate_cyc, 2 hits
SMARTiView protein in SMART
SM00044 CYCc, 2 hits
SUPFAMiSSF55073 SSF55073, 2 hits
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 2 hits
PS50125 GUANYLATE_CYCLASE_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2K6AX62_MACNE
AccessioniPrimary (citable) accession number: A0A2K6AX62
Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: November 7, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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