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Entry version 15 (07 Apr 2021)
Sequence version 1 (28 Mar 2018)
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Protein
Submitted name:

Uncharacterized protein

Gene

TNRC6A

Organism
Mandrillus leucophaeus (Drill) (Papio leucophaeus)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNRC6AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMandrillus leucophaeus (Drill) (Papio leucophaeus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9568 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMandrillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000233140 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 15Sequence analysisAdd BLAST15
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501443220816 – 1981Sequence analysisAdd BLAST1966

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1093 – 1221Ago_hookInterPro annotationAdd BLAST129
Domaini1524 – 1797TNRC6-PABC_bdgInterPro annotationAdd BLAST274

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni51 – 172DisorderedSequence analysisAdd BLAST122
Regioni193 – 332DisorderedSequence analysisAdd BLAST140
Regioni351 – 383DisorderedSequence analysisAdd BLAST33
Regioni457 – 722DisorderedSequence analysisAdd BLAST266
Regioni738 – 1161DisorderedSequence analysisAdd BLAST424
Regioni1269 – 1288DisorderedSequence analysisAdd BLAST20
Regioni1367 – 1388DisorderedSequence analysisAdd BLAST22
Regioni1443 – 1524DisorderedSequence analysisAdd BLAST82
Regioni1596 – 1656DisorderedSequence analysisAdd BLAST61
Regioni1741 – 1772DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi66 – 117PolarSequence analysisAdd BLAST52
Compositional biasi193 – 250PolarSequence analysisAdd BLAST58
Compositional biasi275 – 330PolarSequence analysisAdd BLAST56
Compositional biasi457 – 696PolarSequence analysisAdd BLAST240
Compositional biasi697 – 721PolyampholyteSequence analysisAdd BLAST25
Compositional biasi738 – 757PolarSequence analysisAdd BLAST20
Compositional biasi769 – 802PolarSequence analysisAdd BLAST34
Compositional biasi821 – 970PolarSequence analysisAdd BLAST150
Compositional biasi1002 – 1024PolyampholyteSequence analysisAdd BLAST23
Compositional biasi1031 – 1100PolarSequence analysisAdd BLAST70
Compositional biasi1114 – 1139PolarSequence analysisAdd BLAST26
Compositional biasi1369 – 1384PolarSequence analysisAdd BLAST16
Compositional biasi1443 – 1501PolarSequence analysisAdd BLAST59
Compositional biasi1745 – 1759Pro-richSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GW182 family.ARBA annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158180

Identification of Orthologs from Complete Genome Data

More...
OMAi
GPWGFPH

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12711, RRM_TNRC6A, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019486, Argonaute_hook_dom
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR032226, TNRC6_PABC-bd
IPR033501, TNRC6A
IPR034924, TNRC6A_RRM

The PANTHER Classification System

More...
PANTHERi
PTHR13020:SF28, PTHR13020:SF28, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10427, Ago_hook, 1 hit
PF16608, TNRC6-PABC_bdg, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928, SSF54928, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2K6AAZ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFLFLFSFLE RGSYCCKTLE SEVAVSQDHT IALQPGQEVQ NPVFKKKKKK
60 70 80 90 100
KKKKKLLKAG CSVPEQIKPS VSQPQPANSN NGTSTATSTN NNAKRATANN
110 120 130 140 150
QQPQQQPQQQ QQQQIXXXXX XXXXXXXXXX XXPQQQPQPQ QPQQQPQALP
160 170 180 190 200
RYPREVPPRF RHQEHKQLLK RGQHFPVIAA NLGSAVKVLN SQSESSALTN
210 220 230 240 250
QQPQNNGEVQ NSKNQSDINH STSGSHYENS QRGLVSSTSD SSTNCKNAVV
260 270 280 290 300
SDLSEKEAWP SVPGSDPELA SECMDADSAS SSESERNITI MASGNTGGEK
310 320 330 340 350
DGLRNSTGLG SQNKFVVGSS SNNVGHGSST GPWGFSHGAI ISTCQVSVDA
360 370 380 390 400
PESKSESSNN RMNAWGTVSS SSNGGLNPST LNSASNHGAW PVLENNGLAL
410 420 430 440 450
KGPVGSGSSG INIQCSTIGQ MPNNQSINSK VSGGSTHGTW GSLQETCESE
460 470 480 490 500
VSGTQKVSFS GQPQNITTEM TGPNNTTNFM TSSLPNSGSV QNNELPSSNT
510 520 530 540 550
GAWRVSTMNH PQMQAPSGMN GTSLSHLSNG ESKSGGSYGT TWGAYGSNYS
560 570 580 590 600
GDKCSGPNGQ ANGDTVNATL MQPGVNGPMG TNFQVNTNKG GGVWESGAAN
610 620 630 640 650
SQSASWGSGN GANSGGSRRG WGTPAQNTGT NLPSGEWNKL PSNQHSNDSA
660 670 680 690 700
NGNGKKFTNG WKSTEEEDQG SATSQTNEQS SVWAKTGGTV ESDGSTESTG
710 720 730 740 750
RLEEKGTGES QSRDRRKIDQ HTLLQSIVNR TDLDPRVLSN SGWGQTPIKQ
760 770 780 790 800
NTAWDTETSP RGERKTDNGT EAWGSSATQT FNSGACIDKT SPNSNDTSSV
810 820 830 840 850
SGWGDPKPAL RWGDSKGSNC QGGWEDDSAA TGMVKSNQWG NCKEEKATWN
860 870 880 890 900
DSQKNKQGWG DGQKSSQGWS VSASDNWGET SRSNHWGEAN KKSSSGGSDS
910 920 930 940 950
DRSVSGWNEL GKTSSFTWGN NINPNNSSGW DESSKPTPSQ GWGDPPKSNQ
960 970 980 990 1000
SLGWGDSSKP VSSPDWNKQQ DIVGSWGIPP ATGKPPGTGW LGGPIPAPTK
1010 1020 1030 1040 1050
EEEPTGWEEP SPESIRRKME IDDGTSAWGD PSKYNYKNVN MWNKNVPNGN
1060 1070 1080 1090 1100
SRSDQQAQVH QLLTPASAIS NKEASSSSGW GEPWGEPSTP ATTVDNGTSA
1110 1120 1130 1140 1150
WGKPIDSGPS WGEPIAAASS TSTWGSSSVG PQALNKSGPK SMQDGWCGDD
1160 1170 1180 1190 1200
MPLPGNRPTG WEEEEDVEIG MWNSNSSQEL NSSLNWPPYT KKMSSKGLSG
1210 1220 1230 1240 1250
KKRRRERGMM KGGNKQEEAW INPFVKQFSN ISFSRDSPEE NVQSNKMDLS
1260 1270 1280 1290 1300
GGMLQDKRME IDKHSLNIGD YNRTVGKGPG SRPQISKESS MERNPYFDKD
1310 1320 1330 1340 1350
GIVADESQNM QFMSSQSMKL PPSNSALPNQ ALGSIAGLGM QNLNSVRQVS
1360 1370 1380 1390 1400
PDYNVAMRCF MFGVGNTAPP AQPLSSSQPN LRAQVPPPLL SPQVPVSLLK
1410 1420 1430 1440 1450
YAPNNGGLNP LFGPQQVAML NQLSQLNQLS QISQLQRLLA QQQRAQSQRS
1460 1470 1480 1490 1500
VPSGNRPQQD QQGRPLSVQQ QMMQQSRQLD PNLLVKQQTP PSQQQPLHQP
1510 1520 1530 1540 1550
AMKSFLDNVM PHTTPELQKG PSPINAFSNF PIGLNSNLNV NMDMNSIKEP
1560 1570 1580 1590 1600
QSRLRKWTTV DSISVNTSLD QNSSKHGAIS SGFRLEESPF VPYDFMNSST
1610 1620 1630 1640 1650
SPASPPGSIG DGWPRAKSPN GSSSVNWPPE FRPGEPWKGY PNIDPETDPY
1660 1670 1680 1690 1700
VTPGSVINNL SINTVREVDH LRDRNSGSSS SLNTTLPSTS AWSSIRASNY
1710 1720 1730 1740 1750
NVPLSSTAQS TSARNSDSKL TWSPGSVTNT SLAHELWKVP LPPKNITAPS
1760 1770 1780 1790 1800
RPPPGLTGQK PPLSTWDNSP LRVGGGWGNS DARYTPGSSW GESSSGRITN
1810 1820 1830 1840 1850
WLVLKNLTPQ IDGSTLRTLC MQHGPLITFH LNLPHGNALV RYSSKEEVVK
1860 1870 1880 1890 1900
AQKSLHMCVL GNTTILAEFA SEEEISRFFA QSQSLTPSPG WQSLGSSQSR
1910 1920 1930 1940 1950
LGSLDCSHSF SSRTDLNHWN GAGLSGTNCG DLHGTSLWGT PHYSTSLWGP
1960 1970 1980
PSSSDPRGIS SPSPINAFLS VDHLGGGGES M
Length:1,981
Mass (Da):212,322
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i97648C9949B12B82
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMLET00000060861; ENSMLEP00000037254; ENSMLEG00000042737

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Genome annotation databases

EnsembliENSMLET00000060861; ENSMLEP00000037254; ENSMLEG00000042737

Phylogenomic databases

GeneTreeiENSGT00940000158180
OMAiGPWGFPH

Family and domain databases

CDDicd12711, RRM_TNRC6A, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR019486, Argonaute_hook_dom
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR032226, TNRC6_PABC-bd
IPR033501, TNRC6A
IPR034924, TNRC6A_RRM
PANTHERiPTHR13020:SF28, PTHR13020:SF28, 1 hit
PfamiView protein in Pfam
PF10427, Ago_hook, 1 hit
PF16608, TNRC6-PABC_bdg, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K6AAZ0_MANLE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K6AAZ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: April 7, 2021
This is version 15 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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