We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - A0A2K5ZCM5 (A0A2K5ZCM5_MANLE)
Protein
CD44 antigen
Gene
CD44
Organism
Mandrillus leucophaeus (Drill) (Papio leucophaeus)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- cytokine receptor activity Source: Ensembl
- hyaluronic acid binding Source: Ensembl
GO - Biological processi
- cartilage development Source: Ensembl
- cellular response to fibroblast growth factor stimulus Source: Ensembl
- hyaluronan catabolic process Source: Ensembl
- monocyte aggregation Source: Ensembl
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
- negative regulation of DNA damage response, signal transduction by p53 class mediator Source: Ensembl
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
- positive regulation of ERK1 and ERK2 cascade Source: Ensembl
- positive regulation of heterotypic cell-cell adhesion Source: Ensembl
- positive regulation of monocyte aggregation Source: Ensembl
- positive regulation of peptidyl-serine phosphorylation Source: Ensembl
- positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
- regulation of lamellipodium morphogenesis Source: Ensembl
- T cell activation Source: Ensembl
- wound healing, spreading of cells Source: Ensembl
Keywordsi
Biological process | Cell adhesionARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: CD44 antigenARBA annotationAlternative name(s): Extracellular matrix receptor IIIARBA annotation GP90 lymphocyte homing/adhesion receptorARBA annotation HUTCH-IARBA annotation Hermes antigenARBA annotation Hyaluronate receptorARBA annotation Phagocytic glycoprotein 1ARBA annotation Phagocytic glycoprotein IARBA annotation |
Gene namesi | Name:CD44Imported |
Organismi | Mandrillus leucophaeus (Drill) (Papio leucophaeus)Imported |
Taxonomic identifieri | 9568 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Mandrillus |
Proteomesi |
|
Subcellular locationi
Other locations
- microvillus ARBA annotation
Cytosol
- cytosol Source: Ensembl
Golgi apparatus
- Golgi apparatus Source: Ensembl
Plasma Membrane
- apical plasma membrane Source: Ensembl
- lamellipodium membrane Source: Ensembl
Other locations
- cell surface Source: Ensembl
- integral component of membrane Source: UniProtKB-KW
- macrophage migration inhibitory factor receptor complex Source: Ensembl
- microvillus Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 650 – 671 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
Cell membraneARBA annotation, Cell projectionARBA annotation, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_5014421993 | 21 – 742 | CD44 antigenSequence analysisAdd BLAST | 722 |
Keywords - PTMi
PhosphoproteinARBA annotationStructurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 120 | LinkInterPro annotationAdd BLAST | 89 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 158 – 217 | DisorderedSequence analysisAdd BLAST | 60 | |
Regioni | 260 – 285 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 372 – 400 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 415 – 568 | DisorderedSequence analysisAdd BLAST | 154 | |
Regioni | 595 – 642 | DisorderedSequence analysisAdd BLAST | 48 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 167 – 196 | Polar residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 260 – 277 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 381 – 400 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 417 – 451 | Polar residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 473 – 487 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 500 – 516 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 529 – 568 | Polar residuesSequence analysisAdd BLAST | 40 |
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00530000063822 |
OrthoDBi | 1098342at2759 |
Family and domain databases
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR016186, C-type_lectin-like/link_sf IPR001231, CD44_antigen IPR043210, CD44_antigen-like IPR016187, CTDL_fold IPR000538, Link_dom |
PANTHERi | PTHR10225, PTHR10225, 2 hits PTHR10225:SF6, PTHR10225:SF6, 2 hits |
Pfami | View protein in Pfam PF00193, Xlink, 1 hit |
PRINTSi | PR00658, CD44 PR01265, LINKMODULE |
SMARTi | View protein in SMART SM00445, LINK, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS01241, LINK_1, 1 hit PS50963, LINK_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
A0A2K5ZCM5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDKFWWYAAW GLCLLQLSLA QIDLNITCRF AGVFHVEKNG RYSISRTEAA
60 70 80 90 100
DLCKAFNSTL PTMAQMEKAL SIGFETCRYG FIEGHVVIPR IQPNSICAAN
110 120 130 140 150
HTGVYILTSN TSQYDTYCFN ASAPLKEDCT SVTDLPNAFD GPITITIVNP
160 170 180 190 200
DGTRYVKKGE YRTNPEDIYP SNPTDDDVSS GSSSERSSTS GGYIFHTFST
210 220 230 240 250
AHPIPDEDGP WITDSTDRIP ATTLMSTSAT ATETATKRQE TQDWFSWLFL
260 270 280 290 300
PSESKSHLHT TTQMAGTSSN TISAGWEPNE ENEDERDRHL SFSGSGIDDD
310 320 330 340 350
EDFISSTIST TPRVFDHTKQ NKDWTQWNPS HSNPEVLLQT TARITDVDRN
360 370 380 390 400
GTTAHEGNWN PEAHPPLIHH EHHEEEETPH STSTIQAIPS STTEETATQK
410 420 430 440 450
EQWFGNRWHE GYLQTPREDS HSTTGTAAAS ALTSHPMQGR TTPSPEDSSW
460 470 480 490 500
TDFFDPISHP MGRGHQAGRR MDMDSSHSTT LQPTADPNTG LVEDLDRTGP
510 520 530 540 550
LSMTTKQSNS QSFSTSHEGL EEDKDHPTTS TLTSSNRNDV TGGRRDPNHS
560 570 580 590 600
EGSTTLLEGY TSHYPDTKES RTFIPVTSAK TGSFGVTEVT VGDSNSNVNH
610 620 630 640 650
SLSGDQDAFY PSGGSHTTHG SESAGHSHGS QEGGANTTSG PVRTPQIPEW
660 670 680 690 700
LIILASLLAL ALILAVCIAV NSRRRCGQKK KLVINSGNGA VDDRKPSGLN
710 720 730 740
GEASKSQEMV HLVNKEPSET PDQFMTADET RNLQNVDMKI GV
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2K5ZCN4 | A0A2K5ZCN4_MANLE | CD44 antigen | CD44 | 493 | Annotation score: | ||
A0A2K5ZCF9 | A0A2K5ZCF9_MANLE | CD44 antigen | CD44 | 699 | Annotation score: | ||
A0A2K5ZCG3 | A0A2K5ZCG3_MANLE | CD44 antigen | CD44 | 429 | Annotation score: | ||
A0A2K5ZCH3 | A0A2K5ZCH3_MANLE | CD44 antigen | CD44 | 340 | Annotation score: | ||
A0A2K5ZCN8 | A0A2K5ZCN8_MANLE | CD44 antigen | CD44 | 361 | Annotation score: | ||
A0A2K5ZCN5 | A0A2K5ZCN5_MANLE | CD44 antigen | CD44 | 355 | Annotation score: | ||
A0A2K5ZCN2 | A0A2K5ZCN2_MANLE | CD44 antigen | CD44 | 206 | Annotation score: | ||
A0A2K5ZCM2 | A0A2K5ZCM2_MANLE | CD44 antigen | CD44 | 83 | Annotation score: |
Sequence databases
RefSeqi | XP_011820909.1, XM_011965519.1 |
Genome annotation databases
Ensembli | ENSMLET00000049044; ENSMLEP00000025510; ENSMLEG00000036902 |
GeneIDi | 105528692 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_011820909.1, XM_011965519.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9568.ENSMLEP00000025510 |
Genome annotation databases
Ensembli | ENSMLET00000049044; ENSMLEP00000025510; ENSMLEG00000036902 |
GeneIDi | 105528692 |
Organism-specific databases
CTDi | 960 |
Phylogenomic databases
GeneTreei | ENSGT00530000063822 |
OrthoDBi | 1098342at2759 |
Family and domain databases
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR016186, C-type_lectin-like/link_sf IPR001231, CD44_antigen IPR043210, CD44_antigen-like IPR016187, CTDL_fold IPR000538, Link_dom |
PANTHERi | PTHR10225, PTHR10225, 2 hits PTHR10225:SF6, PTHR10225:SF6, 2 hits |
Pfami | View protein in Pfam PF00193, Xlink, 1 hit |
PRINTSi | PR00658, CD44 PR01265, LINKMODULE |
SMARTi | View protein in SMART SM00445, LINK, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS01241, LINK_1, 1 hit PS50963, LINK_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A2K5ZCM5_MANLE | |
Accessioni | A0A2K5ZCM5Primary (citable) accession number: A0A2K5ZCM5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 28, 2018 |
Last sequence update: | March 28, 2018 | |
Last modified: | January 19, 2022 | |
This is version 22 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |