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Entry version 12 (05 Jun 2019)
Sequence version 1 (28 Mar 2018)
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Protein
Submitted name:

Uncharacterized protein

Gene

CELSR3

Organism
Mandrillus leucophaeus (Drill) (Papio leucophaeus)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptorSAAS annotation, Receptor, Transducer
LigandCalciumSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CELSR3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMandrillus leucophaeus (Drill) (Papio leucophaeus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9568 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMandrillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000233140 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Whole Genome Shotgun Assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2550 – 2574HelicalSequence analysisAdd BLAST25
Transmembranei2586 – 2606HelicalSequence analysisAdd BLAST21
Transmembranei2612 – 2634HelicalSequence analysisAdd BLAST23
Transmembranei2655 – 2675HelicalSequence analysisAdd BLAST21
Transmembranei2695 – 2716HelicalSequence analysisAdd BLAST22
Transmembranei2737 – 2758HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32Sequence analysisAdd BLAST32
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501447267433 – 3325Sequence analysisAdd BLAST3293

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1423 ↔ 1432PROSITE-ProRule annotation
Disulfide bondi1461 ↔ 1470PROSITE-ProRule annotation
Disulfide bondi1748 ↔ 1757PROSITE-ProRule annotation
Disulfide bondi2010 ↔ 2019PROSITE-ProRule annotation
Disulfide bondi2077 ↔ 2089PROSITE-ProRule annotation
Disulfide bondi2079 ↔ 2096PROSITE-ProRule annotation
Disulfide bondi2098 ↔ 2107PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1375 – 1433EGF-likeInterPro annotationAdd BLAST59
Domaini1435 – 1471EGF-likeInterPro annotationAdd BLAST37
Domaini1475 – 1514EGF-likeInterPro annotationAdd BLAST40
Domaini1515 – 1719LAM_G_DOMAINInterPro annotationAdd BLAST205
Domaini1722 – 1758EGF-likeInterPro annotationAdd BLAST37
Domaini1764 – 1944LAM_G_DOMAINInterPro annotationAdd BLAST181
Domaini1946 – 1979EGF-likeInterPro annotationAdd BLAST34
Domaini1982 – 2020EGF-likeInterPro annotationAdd BLAST39
Domaini2077 – 2124Laminin EGF-likeInterPro annotationAdd BLAST48
Domaini2109 – 2191G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST83
Domaini2489 – 2541GPSInterPro annotationAdd BLAST53
Domaini2551 – 2788G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST238

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni89 – 198DisorderedSequence analysisAdd BLAST110
Regioni215 – 306DisorderedSequence analysisAdd BLAST92
Regioni2372 – 2411DisorderedSequence analysisAdd BLAST40
Regioni2901 – 2955DisorderedSequence analysisAdd BLAST55
Regioni2990 – 3021DisorderedSequence analysisAdd BLAST32
Regioni3097 – 3256DisorderedSequence analysisAdd BLAST160
Regioni3269 – 3325DisorderedSequence analysisAdd BLAST57

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi103 – 119PolyampholyteSequence analysisAdd BLAST17
Compositional biasi2378 – 2403PolarSequence analysisAdd BLAST26
Compositional biasi2928 – 2955PolyampholyteSequence analysisAdd BLAST28
Compositional biasi2992 – 3013PolarSequence analysisAdd BLAST22
Compositional biasi3122 – 3136PolyampholyteSequence analysisAdd BLAST15
Compositional biasi3209 – 3223PolyampholyteSequence analysisAdd BLAST15
Compositional biasi3269 – 3315PolarSequence analysisAdd BLAST47

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.SAAS annotation

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, Laminin EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160077

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR000203 GPS
IPR002049 Laminin_EGF
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002 7tm_2, 1 hit
PF00028 Cadherin, 8 hits
PF00008 EGF, 2 hits
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF02793 HRM, 1 hit
PF00053 Laminin_EGF, 1 hit
PF02210 Laminin_G_2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN
PR00249 GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 9 hits
SM00181 EGF, 6 hits
SM00179 EGF_CA, 5 hits
SM00180 EGF_Lam, 1 hit
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00282 LamG, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 9 hits
SSF49899 SSF49899, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 6 hits
PS00022 EGF_1, 4 hits
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 6 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50025 LAM_G_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A2K5Z0Q7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMARRPPWRG LGGRSTPILL LLLLSLFPLS QEELGGGGHQ GWDPRLAATT
60 70 80 90 100
GLRPHIGGGA LALCPESPGV REDGGPGLGV REPVFVGLRG ERQSSRNSRG
110 120 130 140 150
PPEQPNEELR IEHGVQPLGS RERETGQGPG SMLHWRPEIS SCGRTGPLQR
160 170 180 190 200
GSLSPGALTP GVPGSGNSSP LPSDFLVRHH GPKPVSSQRN AGTGARKRVG
210 220 230 240 250
TARCCGELWA IGSKSQGERA TTSGAERTAP RRNCLPGASG SGPELDSAPR
260 270 280 290 300
TARTAPAPGS APRESRTAPK PAPERMRSRG LFRRRFLPQR PGPRPPGIPA
310 320 330 340 350
RPEARKITSA NRARFRRAAN RHPQFPQYNY QTLVPENEAA GTAVLRVVAQ
360 370 380 390 400
DPDAGEAGRL VYSLAALMNS RSLELFSIDP QSGLIRTAAA LDRESMERHY
410 420 430 440 450
LRVTAQDHGS PRLSATTMVA VTVADRNDHS PVFEQAQYRE TLRENVEEGY
460 470 480 490 500
PILQLRATDG DAPPNANLRY RFVGPPAARA AAAAAFEIDP RSGLISTSGR
510 520 530 540 550
VDREHMESYE LVVEASDQGQ EPGPRSATVR VHITVLDEND NAPQFSEKRY
560 570 580 590 600
VAQVREDVRP HTVVLRVTAT DRDKDANGLV HYNIISGNSR GHFAIDSLTG
610 620 630 640 650
EIQVVAPLDF EAEREYALRI RAQDAGRPPL SNNTGLASIQ VVDINDHIPI
660 670 680 690 700
FVSTPFQVSV LENAPLGHSV IHIQAVDADH GENARLEYSL TGVASDTPFV
710 720 730 740 750
INSATGWVSV SGPLDRESVE HYFFGVEARD HGSPPLSASA SVTVTVLDVN
760 770 780 790 800
DNRPEFTMKE YHLRLNEDAA VGTSVVSVTA VDRDANSAIS YQITGGNTRN
810 820 830 840 850
RFAISTQGGV GLVTLALPLD YKQERYFKLV LTASDRALHD HCYVHINITD
860 870 880 890 900
ANTHRPVFQS AHYSVSVNED RPVGSTIVVI SASDDDVGEN ARITYLLEDN
910 920 930 940 950
LPQFRIDADS GAITLQAPLD YEDQVTYTLA ITARDNGIPQ KADTTYVEVM
960 970 980 990 1000
VNDVNDNAPQ FVASHYTGLV SEDAPPFTSV LQISATDRDA HANGRVQYTF
1010 1020 1030 1040 1050
QNGEDGDGDF TIEPTSGIVR TVRRLDREAV SVYELTAYAV DRGVPPLRTP
1060 1070 1080 1090 1100
VSIQVTVQDV NDNAPVFPAE EFEVRVKENS IVGSVVAQIT AVDPDEGPNA
1110 1120 1130 1140 1150
HIMYQIVEGN IPELFQMDIF SGELTALIDL DYEARQEYVI VVQATSAPLV
1160 1170 1180 1190 1200
SRATVHVRLI DQNDNSPVLN NFQILFNNYV SNRSDTFPSG IIGRIPAYDP
1210 1220 1230 1240 1250
DVSDHLFYSF ERGNELQLLV VNQTSGELRL SRKLDNNRPL VASMLVTVTD
1260 1270 1280 1290 1300
GLHSVTAQCV LRVVIITEEL LANSLTVRLE NMWQERFLSP LLGRFLEGVA
1310 1320 1330 1340 1350
EVLATPAEDV FIFNIQNDTD VGGTVLNVSF SALAPRGAGA GAAGPWFSSE
1360 1370 1380 1390 1400
ELQEQLYVRR AALAARSLLD VLPFDDNVCL REPCENYMKC VSVLRFDSSA
1410 1420 1430 1440 1450
PFLASASTLF RPIQPIAGLR CRCPPGFTGD FCETELDLCY SNPCRNGGAC
1460 1470 1480 1490 1500
ARREGGYTCV CRPRFTGEDC ELDTEAGRCV PGVCRNGGTC TNAPNGGFRC
1510 1520 1530 1540 1550
QCPAGGAFEG PRCEVAARSF PPSSFVMFRG LRQRFHLTLS LSFATVQQSG
1560 1570 1580 1590 1600
LLFYNGRLNE KHDFLALELV AGQVRLTYST GESNTVVSPT VPGGLSDGQW
1610 1620 1630 1640 1650
HTVHLKYYNK PRTDALGGAQ GPSKDKVAVL SVDDCDVAVA LQFGAEIGNY
1660 1670 1680 1690 1700
SCAAAGVQTS SKKSLDLTGP LLLGGVPNLP ENFPVSHKDF IGCMRDLHID
1710 1720 1730 1740 1750
GRRMDMAAFV ANNGTMAGCQ AKLHFCDSGP CKNSGFCSER WGGFSCDCPV
1760 1770 1780 1790 1800
GFGGKDCRLT MAHPHHFRGN GTLSWNFGSD MAVSVPWYLG LAFRTRATQG
1810 1820 1830 1840 1850
VLMQVQAGPH STLLCQLDRG LLSVTVTRGS GRASHLLLDQ VTVSDGRWHD
1860 1870 1880 1890 1900
LRLELQEEPG GRRGHHVLMV SLDFSLFQDT MAVGSELQGL KVKQLHVGGL
1910 1920 1930 1940 1950
PPGSAEEAPQ GLVGCIQGVW LGSTPSGSPA LLPPSHQVNA EPGCVMTNAC
1960 1970 1980 1990 2000
ASGPCPPHAD CRDLWQTFSC ICRPGYYGPG CVDACLLNPC QNQGSCRHLP
2010 2020 2030 2040 2050
GAPHGYTCDC VGGYFGHHCE HRMDQQCPRG WWGSPTCGPC NCDVHKGFDP
2060 2070 2080 2090 2100
NCNKTNGQCH CKEFHYRPRG SDSCLPCDCY PVGSTSRSCA PHSGQCPCRP
2110 2120 2130 2140 2150
GALGRQCNSC DSPFAEVTAS GCRVLYDACP KSLRSGVWWP QTKFGVLATV
2160 2170 2180 2190 2200
PCPRGALGLI RGCLPPGAAV RLCDEAQGWL EPDLFNCTSP AFRELSLLVR
2210 2220 2230 2240 2250
LLSWLPFNLL DGLELNKTLA QRLREVTGHT DHYFSQDVRV TARLLAHLLA
2260 2270 2280 2290 2300
FESHQQGFGL TATQDAHFNE NLLWAGSALL APETGDLWAA LGQRAPGGSP
2310 2320 2330 2340 2350
GSAGLVRHLE EYAATLARNM ELTYLNPMGL VTPNIMLSID RMEHPSSPRG
2360 2370 2380 2390 2400
ARRYPRYHSN LFRGQDAWDP HTHVLLPSQS PRPVSLSPQP DTISSMENST
2410 2420 2430 2440 2450
TSSVVPPPAP PEPEPGISII ILLVYRTLGG LLPAQFQAER RGARLPQNPV
2460 2470 2480 2490 2500
MNSPVVSVAV FHGRNFLRGV LESPISLEFR LLQTANRSKA ICVQWDPPGL
2510 2520 2530 2540 2550
AEQHGVWTAR DCELVHRNGS HARCRCSRTG TFGVLMDASP RERLEGDLEL
2560 2570 2580 2590 2600
LAVFTHVVVA VSVAALVLTA AVLLSLRSLK SNVRAIHANV AAALGMAELL
2610 2620 2630 2640 2650
FLLGIHRTHN QLVCTAVAIL LHYFFLSTFA WLFVQGLHLY RMQVEPRNVD
2660 2670 2680 2690 2700
RGAMRFYHAL GWGVPAVLLG LAVGLDPEGY GNPDFCWISV HEPLIWSFAG
2710 2720 2730 2740 2750
PIVLVIVMNG TMFLLAARTS CSTGQREAKK TSALRTLRSS FLLLLLVSAS
2760 2770 2780 2790 2800
WLFGLLAVNH SILAFHYLHA GLCGLQGLAA LLLFCVLNAD ARAAWTPACL
2810 2820 2830 2840 2850
GRKAAPEEAR PAPGTGPGAY NNTALFEESG LIRITLGAST VSSVSSARSG
2860 2870 2880 2890 2900
RTQDQDSQRG RSYLRDNVLV RHGSAADHTD HSLQAHAGPT DLDVAMFHRD
2910 2920 2930 2940 2950
AGADSDSDSD LSLEEERSLS IPSSESEDNG RTRGRFQRPL RRAAQSERLL
2960 2970 2980 2990 3000
THPKDVDGND LLSYWPALGE CEAAPCALQT WGSERRLGLD TNKDAANNNQ
3010 3020 3030 3040 3050
PDPALTSGDE TSLGRAQRQR KGILKNRLQY PLVPQTRGAP ELSWCRAATL
3060 3070 3080 3090 3100
GHRAVPAASY GRIYAGRGTG SLSQPASRYS SREQLDLLLR RQLSRERLEE
3110 3120 3130 3140 3150
APDPVPHPLS RPGSQECMDA APGRLEPRDR GSTLPRRQPP RDYPGAMAGR
3160 3170 3180 3190 3200
FGSRDALDLG APREWLSTLP PPRCTRDLDP QPPPLSLSPQ RQLSRDPLLP
3210 3220 3230 3240 3250
SRPLDSLSRS SNSRERLDQV PSRHPSREAL GPPPQLLRAR EDPVSGPSHG
3260 3270 3280 3290 3300
PSTEQLDILS SILASFNSSA LSSVQYSSTP SGPHTTATPS ATASVLGPST
3310 3320
PRSATSHSIS ELSPDSEVPR SEGHS
Length:3,325
Mass (Da):360,349
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1F52C3118AEB26CC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K5Z0M5A0A2K5Z0M5_MANLE
Uncharacterized protein
CELSR3
3,312Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMLET00000044881; ENSMLEP00000021381; ENSMLEG00000034854

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMLET00000044881; ENSMLEP00000021381; ENSMLEG00000034854

Phylogenomic databases

GeneTreeiENSGT00940000160077

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR000203 GPS
IPR002049 Laminin_EGF
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF00028 Cadherin, 8 hits
PF00008 EGF, 2 hits
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF02793 HRM, 1 hit
PF00053 Laminin_EGF, 1 hit
PF02210 Laminin_G_2, 2 hits
PRINTSiPR00205 CADHERIN
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00112 CA, 9 hits
SM00181 EGF, 6 hits
SM00179 EGF_CA, 5 hits
SM00180 EGF_Lam, 1 hit
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00282 LamG, 2 hits
SUPFAMiSSF49313 SSF49313, 9 hits
SSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 6 hits
PS00022 EGF_1, 4 hits
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 6 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50025 LAM_G_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K5Z0Q7_MANLE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K5Z0Q7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: June 5, 2019
This is version 12 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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