Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Methionine aminopeptidase

Gene

METAP1D

Organism
Mandrillus leucophaeus (Drill) (Papio leucophaeus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Co2+UniRule annotation, Zn2+UniRule annotation, Mn2+UniRule annotation, Fe2+UniRule annotationNote: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei173SubstrateUniRule annotation1
Metal bindingi190Divalent metal cation 1UniRule annotation1
Metal bindingi201Divalent metal cation 1UniRule annotation1
Metal bindingi201Divalent metal cation 2; catalyticUniRule annotation1
Metal bindingi264Divalent metal cation 2; catalytic; via tele nitrogenUniRule annotation1
Binding sitei271SubstrateUniRule annotation1
Metal bindingi296Divalent metal cation 2; catalyticUniRule annotation1
Metal bindingi327Divalent metal cation 1UniRule annotation1
Metal bindingi327Divalent metal cation 2; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminopeptidaseUniRule annotation, Hydrolase, Protease
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidaseUniRule annotation (EC:3.4.11.18UniRule annotation)
Gene namesi
Name:METAP1DImported
OrganismiMandrillus leucophaeus (Drill) (Papio leucophaeus)Imported
Taxonomic identifieri9568 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMandrillus
Proteomesi
  • UP000233140 Componenti: Whole Genome Shotgun Assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini109 – 333Peptidase_M24InterPro annotationAdd BLAST225

Sequence similaritiesi

Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000002284

Family and domain databases

CDDicd01086 MetAP1, 1 hit
HAMAPiMF_01974 MetAP_1, 1 hit
InterProiView protein in InterPro
IPR036005 Creatinase/aminopeptidase-like
IPR000994 Pept_M24
IPR001714 Pept_M24_MAP
IPR002467 Pept_M24A_MAP1
PfamiView protein in Pfam
PF00557 Peptidase_M24, 1 hit
PRINTSiPR00599 MAPEPTIDASE
SUPFAMiSSF55920 SSF55920, 1 hit
TIGRFAMsiTIGR00500 met_pdase_I, 1 hit
PROSITEiView protein in PROSITE
PS00680 MAP_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A2K5YKM2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQNEERRKGK GGRGEQVLLA QYRTASSHRI FSSPLNHIYL HKQSSRQQRR
60 70 80 90 100
NFFFRRQRDI SHSIVLPAAV SSAHPVPKHI KKPDYVTTGI VPDWGDSIEV
110 120 130 140 150
KNEDQIQGLH QACQLARHVL LLAGKSLKVD MTTEEIDALV HREIISHNAY
160 170 180 190 200
PSPLGYGGFP KSVCTSVNNV LCHGIPDSRP LQDGDIINID VTVYYNGYHG
210 220 230 240 250
DTSETFLVGN VDECGKKLVE VARRCRDEAI AACRAGAPFS VIGNTISHIT
260 270 280 290 300
NQNGLQVCPH FVGHGIGSYF HGHPEIWHHA NDNDLPMEEG MAFTIEPIIT
310 320 330 340
EGSPEFKVLE DAWTVVSLDN QRSAQFEHTV LITSRGAQIL TKLPHEA
Length:347
Mass (Da):38,627
Last modified:March 28, 2018 - v1
Checksum:i4EC69D963AC423B1
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K5YKQ0A0A2K5YKQ0_MANLE
Methionine aminopeptidase
METAP1D
330Annotation score:
A0A2K5YKQ9A0A2K5YKQ9_MANLE
Uncharacterized protein
METAP1D
146Annotation score:

Sequence databases

RefSeqiXP_011847354.1, XM_011991964.1

Genome annotation databases

EnsembliENSMLET00000039583; ENSMLEP00000016117; ENSMLEG00000032246
GeneIDi105548110

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_011847354.1, XM_011991964.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMLET00000039583; ENSMLEP00000016117; ENSMLEG00000032246
GeneIDi105548110

Organism-specific databases

CTDi254042

Phylogenomic databases

GeneTreeiENSGT00390000002284

Family and domain databases

CDDicd01086 MetAP1, 1 hit
HAMAPiMF_01974 MetAP_1, 1 hit
InterProiView protein in InterPro
IPR036005 Creatinase/aminopeptidase-like
IPR000994 Pept_M24
IPR001714 Pept_M24_MAP
IPR002467 Pept_M24A_MAP1
PfamiView protein in Pfam
PF00557 Peptidase_M24, 1 hit
PRINTSiPR00599 MAPEPTIDASE
SUPFAMiSSF55920 SSF55920, 1 hit
TIGRFAMsiTIGR00500 met_pdase_I, 1 hit
PROSITEiView protein in PROSITE
PS00680 MAP_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2K5YKM2_MANLE
AccessioniPrimary (citable) accession number: A0A2K5YKM2
Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: October 10, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again