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Protein

Dihydropyrimidine dehydrogenase [NADP(+)]

Gene

DPYD

Organism
Mandrillus leucophaeus (Drill) (Papio leucophaeus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.UniRule annotation

Catalytic activityi

5,6-dihydrouracil + NADP+ = uracil + NADPH.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • FADUniRule annotation
  • FMNUniRule annotation
  • [4Fe-4S] clusterUniRule annotationNote: Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.UniRule annotation

Pathwayi: beta-alanine biosynthesis

This protein is involved in the pathway beta-alanine biosynthesis, which is part of Amino-acid biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway beta-alanine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Ligand4Fe-4SUniRule annotation, FADUniRule annotation, Flavoprotein, FMNUniRule annotation, Iron, Iron-sulfur, Metal-binding, NADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00131

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropyrimidine dehydrogenase [NADP(+)]UniRule annotation (EC:1.3.1.2UniRule annotation)
Short name:
DHPDHaseUniRule annotation
Short name:
DPDUniRule annotation
Alternative name(s):
Dihydrothymine dehydrogenaseUniRule annotation
Dihydrouracil dehydrogenaseUniRule annotation
Gene namesi
Name:DPYDImported
OrganismiMandrillus leucophaeus (Drill) (Papio leucophaeus)Imported
Taxonomic identifieri9568 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMandrillus
Proteomesi
  • UP000233140 Componenti: Whole Genome Shotgun Assembly

Subcellular locationi

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 1004Fe-4S ferredoxin-typeInterPro annotationAdd BLAST32
Domaini944 – 9764Fe-4S ferredoxin-typeInterPro annotationAdd BLAST33
Domaini978 – 10074Fe-4S ferredoxin-typeInterPro annotationAdd BLAST30

Sequence similaritiesi

Belongs to the dihydropyrimidine dehydrogenase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00500000044896

Family and domain databases

Gene3Di1.10.1060.10, 1 hit
3.20.20.70, 1 hit
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR013785 Aldolase_TIM
IPR005720 Dihydroorotate_DH
IPR028261 DPD_II
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR009051 Helical_ferredxn
PfamiView protein in Pfam
PF01180 DHO_dh, 1 hit
PF14691 Fer4_20, 1 hit
PF07992 Pyr_redox_2, 1 hit
SUPFAMiSSF46548 SSF46548, 1 hit
TIGRFAMsiTIGR01037 pyrD_sub1_fam, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 3 hits

Sequencei

Sequence statusi: Complete.

A0A2K5YJ87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVLSKDSA DIESILALNP RTQTHATLRS TSAKKLDKKH WKRNPDKNCF
60 70 80 90 100
NCEKLENNFD DIKHTTLGER GALREAMRCL KCADAPCQKS CPTNLDIKSF
110 120 130 140 150
ITSIANKNYY GAAKMIFSDN PLGLTCGMVC PTSDLCVGGC NLYATEEGPI
160 170 180 190 200
NIGGLQQFAT EVFKAMSIPQ IRNPSLPPPE KMSEAYSAKI ALFGAGPASI
210 220 230 240 250
SCASFLARLG YSDITIFEKQ EYVGGLSTSE IPQFRLPYDV VNFEIELMKD
260 270 280 290 300
LGVKIICGKS LSVNEMTLST LKEKGYKAAF IGIGLPEPNK DAIFQGLTRD
310 320 330 340 350
QGFYTSKDFL PLVAKGSKAG MCACHSPLPS IRGVVIVLGA GDTAFDCATS
360 370 380 390 400
ALRCGARRVF IVFRKGFVNI RAVPEEMELA KEEKCEFLPF LSPRKVIVKG
410 420 430 440 450
GRIAAMQFVR TEQDETGKWN EDEDQMVHLK ADVVISAFGS VLSDPKVKEA
460 470 480 490 500
LSPIKFNRWG LPEVDPETMQ TSEPWVFAGG DVIGLANTTV ESVNDGKQAS
510 520 530 540 550
WYIHKYIQSQ YGASISAKPE LPLFYTPIDL VDISVEMAGL KFINPFGLAS
560 570 580 590 600
ATPATSTSMI RRAFEAGWGF ALTKTFSLDK DIVTNVSPRI IRGTTSGPMY
610 620 630 640 650
GPGQSSFLNI ELISEKTAAY WCQSVTELKA DFPDNIVIAS IMCSYNKNDW
660 670 680 690 700
MELAKKSEDS GADALELNLS CPHGMGERGM GLACGQDPEL VRNICRWVRQ
710 720 730 740 750
AVQIPFFAKL TPNVTDIVSI ARAAKEGGAD GVTATNTVSG LMGLKSDGTP
760 770 780 790 800
WPAVGIAKRT TYGGVSGTAI RPIALRAVTS IARALPGFPI LATGGIDSAE
810 820 830 840 850
SGLQFLHSGA SVLQVCSAIQ NQDFTVIEDY CTGLKALLYL KSIEELQDWD
860 870 880 890 900
GQSPATVSHQ KGKPVPRIAE LMDKKLPSFG PYLEQRKKII AENKIRLKEQ
910 920 930 940 950
NAAFSPLKRN CFIPKWPVPT IKDVIGKALQ YLGTFGELSN VEQVVAMIDE
960 970 980 990 1000
EMCINCGKCY MTCNDSGYQA IRFDPETHLP TITDTCTGCT LCLSVCPIVD
1010 1020
CIKMVSRTTP YEPKRGVPLS VDPVC
Length:1,025
Mass (Da):111,571
Last modified:March 28, 2018 - v1
Checksum:iB1D2A310F3AFB7FC
GO

Sequence databases

RefSeqiXP_011824724.1, XM_011969334.1

Genome annotation databases

EnsembliENSMLET00000039041; ENSMLEP00000015580; ENSMLEG00000031938
GeneIDi105531412

Similar proteinsi

Entry informationi

Entry nameiA0A2K5YJ87_MANLE
AccessioniPrimary (citable) accession number: A0A2K5YJ87
Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: July 18, 2018
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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