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UniProtKB - A0A2K5X283 (A0A2K5X283_MACFA)
Protein
Angiotensin-converting enzyme
Gene
ACE2
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Functioni
Catalytic activityi
- This reaction proceeds in the forwardARBA annotation direction.
- EC:3.4.17.23ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
Cofactori
Protein has several cofactor binding sites:GO - Molecular functioni
- carboxypeptidase activity Source: UniProtKB-KW
- endopeptidase activity Source: Ensembl
- identical protein binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- metallopeptidase activity Source: UniProtKB-KW
- peptidyl-dipeptidase activity Source: Ensembl
- virus receptor activity Source: Ensembl
GO - Biological processi
- angiotensin-mediated drinking behavior Source: Ensembl
- negative regulation of signaling receptor activity Source: Ensembl
- positive regulation of cardiac muscle contraction Source: Ensembl
- positive regulation of gap junction assembly Source: Ensembl
- positive regulation of L-proline import across plasma membrane Source: Ensembl
- receptor-mediated virion attachment to host cell Source: Ensembl
- regulation of cardiac conduction Source: Ensembl
- regulation of transmembrane transporter activity Source: Ensembl
- tryptophan transport Source: Ensembl
Keywordsi
Molecular function | CarboxypeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease |
Ligand | Metal-bindingUniRule annotationARBA annotation, ZincUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ACE2Imported |
Organismi | Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)Imported |
Taxonomic identifieri | 9541 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSMFAG00000039194 |
Subcellular locationi
Plasma membrane
- Apical cell membrane ARBA annotation
Extracellular region or secreted
- Secreted ARBA annotation
Cytoplasm and Cytosol
- Cytoplasm ARBA annotation
Other locations
- cilium ARBA annotation
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Extracellular region or secreted
- extracellular space Source: Ensembl
Plasma Membrane
- apical plasma membrane Source: Ensembl
- brush border membrane Source: Ensembl
Other locations
- cell surface Source: Ensembl
- cilium Source: UniProtKB-SubCell
- cytoplasm Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 742 – 765 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
Cell membraneARBA annotation, Cell projectionARBA annotation, CytoplasmARBA annotation, Membrane, SecretedARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_5014429529 | 18 – 805 | Angiotensin-converting enzymeSequence analysisAdd BLAST | 788 |
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinUniRule annotationARBA annotation, PhosphoproteinARBA annotationInteractioni
GO - Molecular functioni
- identical protein binding Source: Ensembl
Protein-protein interaction databases
IntActi | A0A2K5X283, 3 interactors |
STRINGi | 9541.XP_005593094.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 617 – 770 | CollectrinInterPro annotationAdd BLAST | 154 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 772 – 805 | DisorderedSequence analysisAdd BLAST | 34 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 777 – 805 | Polar residuesSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Keywords - Domaini
SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000158077 |
OMAi | TPRISFY |
OrthoDBi | 422699at2759 |
Family and domain databases
CDDi | cd06461, M2_ACE, 1 hit |
InterProi | View protein in InterPro IPR031588, Collectrin_dom IPR001548, Peptidase_M2 |
PANTHERi | PTHR10514, PTHR10514, 1 hit |
Pfami | View protein in Pfam PF16959, Collectrin, 1 hit PF01401, Peptidase_M2, 1 hit |
PRINTSi | PR00791, PEPDIPTASEA |
i Sequence
Sequence statusi: Complete.
A0A2K5X283-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGSSWLLLS LVAVTAAQST IEEQAKTFLD KFNHEAEDLF YQSSLASWNY
60 70 80 90 100
NTNITEENVQ NMNNAGEKWS AFLKEQSTLA QMYPLQEIQN LTVKLQLQAL
110 120 130 140 150
QQNGSSVLSE DKSKRLNTIL NTMSTIYSTG KVCNPNNPQE CLLLDPGLNE
160 170 180 190 200
IMEKSLDYNE RLWAWEGWRS EVGKQLRPLY EEYVVLKNEM ARANHYKDYG
210 220 230 240 250
DYWRGNYEVN GVDGYDYNRD QLIEDVERTF EEIKPLYEHL HAYVRAKLMN
260 270 280 290 300
AYPSYISPTG CLPAHLLGDM WGRFWTNLYS LTVPFGQKPN IDVTDAMVNQ
310 320 330 340 350
AWNAQRIFKE AEKFFVSVGL PNMTQGFWEN SMLTDPGNVQ KVVCHPTAWD
360 370 380 390 400
LGKGDFRIIM CTKVTMDDFL TAHHEMGHIQ YDMAYAAQPF LLRNGANEGF
410 420 430 440 450
HEAVGEIMSL SAATPKHLKS IGLLSPDFQE DNETEINFLL KQALTIVGTL
460 470 480 490 500
PFTYMLEKWR WMVFKGEIPK DQWMKKWWEM KREIVGVVEP VPHDETYCDP
510 520 530 540 550
ASLFHVSNDY SFIRYYTRTL YQFQFQEALC QAAKHEGPLH KCDISNSTEA
560 570 580 590 600
GQKLLNMLKL GKSEPWTLAL ENVVGAKNMN VRPLLNYFEP LFTWLKDQNK
610 620 630 640 650
NSFVGWSTDW SPYADQSIKV RISLKSALGD KAYEWNDNEM YLFRSSVAYA
660 670 680 690 700
MRTYFLEIKH QTILFGEEDV RVADLKPRIS FNFYVTAPKN VSDIIPRTEV
710 720 730 740 750
EEAIRISRSR INDAFRLNDN SLEFLGIQTT LAPPYQSPVT TWLIVFGVVM
760 770 780 790 800
GVIVAGIVVL IFTGIRDRKK KNQARSEENP YASIDINKGE NNPGFQNTDD
VQTSF
Sequence databases
RefSeqi | XP_005593094.1, XM_005593037.2 |
Genome annotation databases
Ensembli | ENSMFAT00000017879; ENSMFAP00000043589; ENSMFAG00000039194 |
GeneIDi | 102130864 |
KEGGi | mcf:102130864 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_005593094.1, XM_005593037.2 |
3D structure databases
SMRi | A0A2K5X283 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | A0A2K5X283, 3 interactors |
STRINGi | 9541.XP_005593094.1 |
Genome annotation databases
Ensembli | ENSMFAT00000017879; ENSMFAP00000043589; ENSMFAG00000039194 |
GeneIDi | 102130864 |
KEGGi | mcf:102130864 |
Organism-specific databases
CTDi | 59272 |
VEuPathDBi | HostDB:ENSMFAG00000039194 |
Phylogenomic databases
GeneTreei | ENSGT00940000158077 |
OMAi | TPRISFY |
OrthoDBi | 422699at2759 |
Family and domain databases
CDDi | cd06461, M2_ACE, 1 hit |
InterProi | View protein in InterPro IPR031588, Collectrin_dom IPR001548, Peptidase_M2 |
PANTHERi | PTHR10514, PTHR10514, 1 hit |
Pfami | View protein in Pfam PF16959, Collectrin, 1 hit PF01401, Peptidase_M2, 1 hit |
PRINTSi | PR00791, PEPDIPTASEA |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A2K5X283_MACFA | |
Accessioni | A0A2K5X283Primary (citable) accession number: A0A2K5X283 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 28, 2018 |
Last sequence update: | March 28, 2018 | |
Last modified: | January 19, 2022 | |
This is version 22 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |