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Entry version 8 (16 Jan 2019)
Sequence version 1 (28 Mar 2018)
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Protein
Submitted name:

Collagen type XXVII alpha 1 chain

Gene

COL27A1

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Collagen type XXVII alpha 1 chainImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL27A1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9541 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 41Sequence analysisAdd BLAST41
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501444732642 – 1853Sequence analysisAdd BLAST1812

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1653 – 1853Fibrillar collagen NC1InterPro annotationAdd BLAST201

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00940000163466

KEGG Orthology (KO)

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KOi
K19721

Database of Orthologous Groups

More...
OrthoDBi
200318at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR000885 Fib_collagen_C
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01410 COLFI, 2 hits
PF01391 Collagen, 10 hits

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00038 COLFI, 1 hit
SM00210 TSPN, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51461 NC1_FIB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2K5WE42-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAGSARGAR GTATAAAAHG GGFLFSWILV SFACHLASTQ GAPEDVDVLQ
60 70 80 90 100
RLGLSWTKAG SPAPPGVIPF QSGFIFTQRA RLQAPTGSVI PASLGTELAL
110 120 130 140 150
VLSLCSHRVN HAFLFAVRSR KHKLQLGLQF LPGKTVVHLG SRRSVAFDLD
160 170 180 190 200
MHDGRWHHLA LELRGRTVTL VTACGQRRVP VLLPFHRDPA LDPGGSFLFG
210 220 230 240 250
KMNPHAVQFE GALCQFSIYP VTQVAHNYCT HLRKQCGQAD TYQSPLGPLF
260 270 280 290 300
SQDSGRPFTF QSDLALLGLE NLTTATPLGS QPAGRGPKGT VVPATPTKPQ
310 320 330 340 350
RTSPTNPHQH IAVQGPAQTP PAKLSASNTL DPVLPASLGS STRTPRPAAS
360 370 380 390 400
QPSQKITATK IPKSLPTKPS APSTSIVPVK SPHPTQKTAA PSFTKSAPPT
410 420 430 440 450
QKHVPTVPAK VSRPAEKPIQ RNQGMPRPPL PSTQPLPPTT SSSKKPIPTL
460 470 480 490 500
AQTEAKVTNH ASKPASARTS THKPPPFTAL SSSPAPTPGS TRTTRPPATM
510 520 530 540 550
VPPTSGTSAP RTAPAVPTPG SAPTGNKKPT GSEASKKAGP ESSPRKPVPL
560 570 580 590 600
RPGKAARDVP LSDLTTRPSP RQSQPSQQTT SALVLAPAQF LSSSPRPTSS
610 620 630 640 650
GYSFFHLAGS TPFPLLMGPP GPKGDCGLPG PPGLPGLPGI PGARGPRGPP
660 670 680 690 700
GPYGNPGLPG PPGAKGQKGD PGLSPGKAHD GAKGDMGLPG LSGNPGPPGR
710 720 730 740 750
KGHKGYPGPA GHPGEQGQPG PEGSPGAKGY PGRQGLPGPV GDPGPKGSRG
760 770 780 790 800
YIGLPGLFGL PGSDGERGLP GVPGKRGKMG MPGFPGVFGE RGPPGLDGNP
810 820 830 840 850
GELGLPGPPG VPGLIGDLGV LGPIGYPGPK GMKGLMGSVG EPGLKGDKGE
860 870 880 890 900
QGVPGVSGDP GFQGDKGSQG LPGFPGARGK PGPLGKVGDK GSIGFPGPPG
910 920 930 940 950
PEGFPGDIGP PGDNGPEGMK GKPGARGLPG PRGQLGPEGD EGPMGPPGAP
960 970 980 990 1000
GLEGQPGRKG FPGRPGLDGV KGEPGDPGRP GPVGEQGFMG FIGLVGEPGI
1010 1020 1030 1040 1050
VGEKGDRGMM GPPGVPGPKG SMGHPGMPGG MGTPGEPGPQ GPPGSRGPPG
1060 1070 1080 1090 1100
MRGAKGRRGP RGPDGPAGEQ GSRGLKGPPG PQGRPGRPGQ QGVAGEQGHL
1110 1120 1130 1140 1150
GSRGFPGIPG PSGPPGTKGL PGEPGPQGPQ GPVGPPGEMG PKGPPGAAGE
1160 1170 1180 1190 1200
PGLPGEAGMK GDLGPLGTPG EQGLIGQRGE PGLEGDSGPM GPDGLKGDRG
1210 1220 1230 1240 1250
DPGPDGEHGE KGQEGLMGED GPPGPPGVTG VRGPEGKSGK QGEKGRTGAK
1260 1270 1280 1290 1300
GAKGYQGQLG EMGVPGDPGP PGTPGPKGSR GSLGPTGAPG RMGAQGEPGL
1310 1320 1330 1340 1350
AGYDGHKGIV GPLGPPGPKG EKGEQGEDGK AEGPPGPPGD RGPVGDRGDR
1360 1370 1380 1390 1400
GEPGDPGYPG QEGVQGLRGK PGQQGQPGHP GPRGRPGPKG SKGAEGPKGK
1410 1420 1430 1440 1450
QGKAGAPGRR GVQGLQGLPG PRGVVGRQGL EGIAGADGLP GRDGQVGQQG
1460 1470 1480 1490 1500
EQGDDGDPGP MGPAGKRGNP GVAGLPGAQG PPGFKGESGL PGQLGPPGKR
1510 1520 1530 1540 1550
GTEGRTGLPG NQGEPGSKGQ PGDSGEMGFP GMAGLFGPKG PPGDIGFKGI
1560 1570 1580 1590 1600
QGPRGPPGLM GKEGIIGPLG ILGPSGLPGP KGDKGSRGDW GLQGPRGPPG
1610 1620 1630 1640 1650
PRGRPGPPGP PGGPIQLQQD DLGVAFQTWM DTSGALRPEG YSYPDRLVLD
1660 1670 1680 1690 1700
QGGEIFKTLH YLSNLIQSIK TPLGTKENPA RVCRDLMDCE QKMVDGTYWV
1710 1720 1730 1740 1750
DPNLGCSSDT IEVSCNFTHG GQTCLKPITA SKVEFAISRV QMNFLHLLSS
1760 1770 1780 1790 1800
EVTQHITIHC LNMTVWQEGT GQTPAKQAVR FRAWNGQIFE AGGQFRPEVS
1810 1820 1830 1840 1850
MDGCKVQDGR WHQTLFTFRT QDPQQLPIVS VDNLPPASSG KQYRLEVGPA

CFL
Length:1,853
Mass (Da):186,144
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2210D5C6BAFEAB24
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AQIA01023716 Genomic DNA No translation available.
AQIA01023717 Genomic DNA No translation available.
AQIA01023718 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
XP_005581034.1, XM_005580977.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMFAT00000009638; ENSMFAP00000035402; ENSMFAG00000040376

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
102118893

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mcf:102118893

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AQIA01023716 Genomic DNA No translation available.
AQIA01023717 Genomic DNA No translation available.
AQIA01023718 Genomic DNA No translation available.
RefSeqiXP_005581034.1, XM_005580977.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMFAT00000009638; ENSMFAP00000035402; ENSMFAG00000040376
GeneIDi102118893
KEGGimcf:102118893

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
85301

Phylogenomic databases

GeneTreeiENSGT00940000163466
KOiK19721
OrthoDBi200318at2759

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR000885 Fib_collagen_C
IPR001791 Laminin_G
PfamiView protein in Pfam
PF01410 COLFI, 2 hits
PF01391 Collagen, 10 hits
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit
SMARTiView protein in SMART
SM00038 COLFI, 1 hit
SM00210 TSPN, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51461 NC1_FIB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K5WE42_MACFA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K5WE42
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: January 16, 2019
This is version 8 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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