Interleukin-33

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cytokine activity Source: UniProtKB-KW
• interleukin-33 receptor binding Source: Ensembl

GO - Biological processⁱ

• defense response to virus Source: Ensembl
• extrinsic apoptotic signaling pathway Source: Ensembl
• interleukin-33-mediated signaling pathway Source: Ensembl
• microglial cell activation involved in immune response Source: Ensembl
• microglial cell proliferation Source: Ensembl
• negative regulation of immunoglobulin secretion Source: Ensembl
• negative regulation of interferon-gamma production Source: Ensembl
• negative regulation of leukocyte migration Source: Ensembl
• negative regulation of macrophage proliferation Source: Ensembl
• negative regulation of T-helper 1 type immune response Source: Ensembl
• negative regulation of transcription by RNA polymerase II Source: Ensembl
• positive regulation of CD80 production Source: Ensembl
• positive regulation of CD86 production Source: Ensembl
• positive regulation of cellular defense response Source: Ensembl
• positive regulation of chemokine secretion Source: Ensembl
• positive regulation of immunoglobulin secretion Source: Ensembl
• positive regulation of inflammatory response Source: Ensembl
• positive regulation of interleukin-13 production Source: Ensembl
• positive regulation of interleukin-4 production Source: Ensembl
• positive regulation of interleukin-5 production Source: Ensembl
• positive regulation of interleukin-6 production Source: Ensembl
• positive regulation of macrophage activation Source: Ensembl
• positive regulation of MHC class I biosynthetic process Source: Ensembl
• positive regulation of MHC class II biosynthetic process Source: Ensembl
• positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
• positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
• positive regulation of transcription by RNA polymerase II Source: Ensembl
• positive regulation of tumor necrosis factor biosynthetic process Source: Ensembl
• positive regulation of tumor necrosis factor secretion Source: Ensembl
• positive regulation of type 2 immune response Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• cytokine activity Source: UniProtKB-KW
• interleukin-33 receptor binding Source: Ensembl

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MKPKMKYSTN KISTAKRKNT ASKALCFKLG KSQQKAKEVC HVYFMKLRSG 
        60         70         80         90        100
LMIKKEACYF RRETTKRPSL KTGGKHKGHL VLAACQQQST VECFAFGISG 
       110        120        130        140        150
VPKYTRALHD SSITGISPIT ESLASLSTYN DQSITFALED ESYEIYVEDL 
       160        170        180        190        200
KKDKKKDKVL LSYYESQHPS SESGDGVDGK MLMVTLSPTK DFWLQANNKE 
       210        220        230        240        250
HSVELHKCEK PLPDQAFFVL HNRSFNCVSF ECKTDPGVFI GVKDNHLALI 
       260        270
KVDYSENLGS ENILFKLSEI                                  

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ