HMG box domain-containing protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• armadillo repeat domain binding Source: Ensembl
• beta-catenin binding Source: Ensembl
• DNA-binding transcription factor activity Source: Ensembl
• gamma-catenin binding Source: Ensembl
• nuclear hormone receptor binding Source: Ensembl
• protein kinase binding Source: Ensembl
• RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
• RNA polymerase II repressing transcription factor binding Source: Ensembl

GO - Biological processⁱ

• blood vessel development Source: Ensembl
• canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition Source: Ensembl
• cell cycle arrest Source: Ensembl
• fat cell differentiation Source: Ensembl
• glucose homeostasis Source: Ensembl
• maintenance of DNA repeat elements Source: Ensembl
• myoblast fate commitment Source: Ensembl
• negative regulation of canonical Wnt signaling pathway Source: Ensembl
• negative regulation of DNA-binding transcription factor activity Source: Ensembl
• negative regulation of transcription by RNA polymerase II Source: Ensembl
• positive regulation of epithelial cell proliferation Source: Ensembl
• positive regulation of heparan sulfate proteoglycan biosynthetic process Source: Ensembl
• positive regulation of insulin secretion Source: Ensembl
• positive regulation of protein binding Source: Ensembl
• positive regulation of protein export from nucleus Source: Ensembl
• positive regulation of protein kinase B signaling Source: Ensembl
• positive regulation of transcription by RNA polymerase II Source: Ensembl
• regulation of hormone metabolic process Source: Ensembl
• regulation of smooth muscle cell proliferation Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• armadillo repeat domain binding Source: Ensembl
• beta-catenin binding Source: Ensembl
• gamma-catenin binding Source: Ensembl
• nuclear hormone receptor binding Source: Ensembl
• protein kinase binding Source: Ensembl
• RNA polymerase II repressing transcription factor binding Source: Ensembl

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MSQLFLGLAV LRLLSEFIVF HFTFVSSRQY LQMKWPLLDV QAGSLQSRQA 
        60         70         80         90        100
LKDARSPSPA HIVQSPLPCC TQGHDCQHFY PPSDFTVSTQ VFRDMKRSHS 
       110        120        130        140        150
LQKVGEPWCI ESNKVPVVQH PHHVHPLTPL ITYSNEHFTP GNPPPHLPAD 
       160        170        180        190        200
VDPKTGIPRP PHPPDISPYY PLSPGTVGQI PHPLGWQGQP VYPITTGGFR 
       210        220        230        240        250
HPYPTALTVN ASMSRFPPHM VPPHHTLHTT GIPHPAIVTP TVKQESSQSD 
       260        270        280        290        300
VGSLHSSKHQ DSKKEEEKKK PHIKKPLNAF MLYMKEMRAK VVAECTLKES 
       310        320        330        340        350
AAINQILGRR WHALSREEQA KYYELARKER QLHMQLYPGW SARDNYGKKK 
       360        370        380        390        400
KRKRDKQPGE TNEHSECFLN PCLSLPPITD ANTPKKCRAL FGLDRQTLWC 
       410        420        430        440        450
KPCRRKKKCV RYIQGEGSCL SPPSSDGSLL DSPPPSPNLL GSPPRDAKSQ 
       460        470        480        490        500
TEQTQPLSLS LKPDPLAHLS MMPPPPALLL AEATHKASAL CPNGALDLPP 
       510        520        530        540 
TALQPAAPSS SVAQPSTSSL HSHSSLAGTQ PQPLSLVTKS LE         

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ