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Entry version 6 (05 Dec 2018)
Sequence version 1 (28 Mar 2018)
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Protein
Submitted name:

Collagen type II alpha 1 chain

Gene

COL2A1

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Collagen type II alpha 1 chainImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL2A1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9541 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1071 – 1305Fibrillar collagen NC1InterPro annotationAdd BLAST235

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155224

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR000885 Fib_collagen_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 5 hits

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00038 COLFI, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51461 NC1_FIB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2K5UUF6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGGFDEKAG GAQMGVMQGP MGPMGPRGPP GPAGAPGPQG FQGNPGEPGE
60 70 80 90 100
PGVSGPMGPR GPPGPPGKPG DDGEAGKPGK AGERGPPGPQ GARGFPGTPG
110 120 130 140 150
LPGVKGHRGY PGLDGAKGEA GAPGVKGESG SPGENGSPGP MGPRGLPGER
160 170 180 190 200
GRTGPAGAAG ARGNDGQPGP AGPPGPVGPA GGPGFPGAPG AKGEAGPTGA
210 220 230 240 250
RGPEGAQGPR GEPGTPGSPG PAGASGNPGT DGIPGAKGSA GAPGIAGAPG
260 270 280 290 300
FPGPRGPPGP QGATGPLGPK GQTGEPGIAG FKGEQGPKGE PGPAGPQGAP
310 320 330 340 350
GPAGEEGKRG ARGEPGGVGP IGPPGERGAP GNRGFPGQDG LAGPKGAPGE
360 370 380 390 400
RGPSGLAGPK GANGDPGRPG EPGLPGARGL TGRPGDAGPQ GKVGPSGAPG
410 420 430 440 450
EDGRPGPPGP QGARGQPGVM GFPGPKGANG EPGKAGEKGL PGAPGLRGLP
460 470 480 490 500
GKDGETGAAG PPGPAGPAGE RGEQGAPGPS GFQGLPGPPG PPGEGGKPGD
510 520 530 540 550
QGVPGEAGAP GLVGPRGERG FPGERGSPGS QGLQGARGLP GTPGTDGPKG
560 570 580 590 600
ASGPAGPPGA QGPPGLQGMP GERGAAGIAG PKGDRGDVGE KGPEGAPGKD
610 620 630 640 650
GGRGLTGPIG PPGPAGANGE KGEVGPPGPA GSAGARGAPG ERGETGPPGP
660 670 680 690 700
AGFAGPPGAD GQPGAKGEQG EAGQKGDAGA PGPQGPSGAP GPQGPTGVTG
710 720 730 740 750
PKGARGAQGP PGATGFPGAA GRVGPPGSNG NPGPPGPPGP SGKDGPKGAR
760 770 780 790 800
GDSGPPGRAG DPGLQGPAGP PGEKGEPGDD GPSGADGPPG PQGLAGQRGI
810 820 830 840 850
VGLPGQRGER GFPGLPGPSG EPGKQGAPGA SGDRGPPGPV GPPGLTGPAG
860 870 880 890 900
EPGREGSPGA DGPPGRDGAA GVKGDRGETG AVGAPGSPGP PGSPGPAGPT
910 920 930 940 950
GKQGDRGEAG AQGPMGPSGP AGARGIQGPQ GPRGDKGEAG EPGERGLKGH
960 970 980 990 1000
RGFTGLQGLP GPPGPSGDQG ASGPAGPSGP RGPPGPVGPS GKDGANGIPG
1010 1020 1030 1040 1050
PIGPPGPRGR SGETGPAGPP GNPGPPGPPG PPGPGIDMSA FAGLGPREKG
1060 1070 1080 1090 1100
PDPLQYMRAD QAAGGLRQHD AEVDATLKSL NNQIESIRSP EGSRKNPART
1110 1120 1130 1140 1150
CRDLKLCHPE WKSGDYWIDP NQGCTLDAMK VFCNMETGET CVYPNPANVP
1160 1170 1180 1190 1200
KKNWWSSKSK EKKHIWFGET INGGFHFSYG DDNLAPNTAN VQMTFLRLLS
1210 1220 1230 1240 1250
TEGSQNITYH CKNSIAYLDE AAGNLKKALL IQGSNDVEIR AEGNSRFTYT
1260 1270 1280 1290 1300
ALKDDCTKHT GKWGKTVIEY RSQKTSRLPI IDIAPMDIGG PEQEFGVDIG

PVCFL
Length:1,305
Mass (Da):123,366
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1027A13358AFAD3C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AQIA01010827 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_015286329.1, XM_015430843.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMFAT00000066633; ENSMFAP00000016103; ENSMFAG00000031247

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
102134921

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AQIA01010827 Genomic DNA No translation available.
RefSeqiXP_015286329.1, XM_015430843.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMFAT00000066633; ENSMFAP00000016103; ENSMFAG00000031247
GeneIDi102134921

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1280

Phylogenomic databases

GeneTreeiENSGT00940000155224

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR000885 Fib_collagen_C
PfamiView protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 5 hits
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit
SMARTiView protein in SMART
SM00038 COLFI, 1 hit
PROSITEiView protein in PROSITE
PS51461 NC1_FIB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K5UUF6_MACFA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K5UUF6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: December 5, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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