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Protein
Submitted name:

Uncharacterized protein

Gene

MUSK

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionKinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:MUSKImported
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)Imported
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei406 – 432HelicalSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 116Ig-likeInterPro annotationAdd BLAST89
Domaini121 – 205Ig-likeInterPro annotationAdd BLAST85
Domaini214 – 312Ig-likeInterPro annotationAdd BLAST99
Domaini489 – 770Protein kinaseInterPro annotationAdd BLAST282

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118818

Family and domain databases

Gene3Di1.10.2000.10, 1 hit
2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR036790 Frizzled_dom_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2K5USG5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRELVNIPLV HILTLVAFSG TEKLPKAPVI TTPLETVDAL VEEVATFMCA
60 70 80 90 100
VESYPQPEIS WTRNKILIKL FDTRYSIREN GQLLTILSVE DSDDGIYCCT
110 120 130 140 150
ANNGVGGAVE SCGALQVKMK PKITRPPINV KIIEGLKAVL PCTTMGNPKP
160 170 180 190 200
SVSWIKGDSP LRENSRTAVL ESGSLRIHNV QKEDAGQYRC VAKNSLGTAY
210 220 230 240 250
SKVVKLEVEE ESEPEQDTKV FARILRAPES HNVTFGSFVT LHCTATGIPV
260 270 280 290 300
PTITWIENGN AVSSGSIQES VKDRVIDSRL QLFITKPGLY TCIATNKHGE
310 320 330 340 350
KFSTAKAAAT ISIAEWREYC LAVKELFCAK EWLAMEEKTH RGLYRSEMHL
360 370 380 390 400
LSVPECSKLP SMHWDPTACA RLPHLAFPPM TSSKPSVDIP NLPSSSSSSF
410 420 430 440 450
SVSPTYSMTV IISIMSSFAI FALLTITTLY CCRRRKQWKN KKRESAAVTL
460 470 480 490 500
TTLPSELLLD RLHPNPMYQR MPLLLNPKLL SLEYPRNNIE YVRDIGEGAF
510 520 530 540 550
GRVFQARAPG LLPYEPFTMV AVKMLKEEAS ADMQADFQRE AALMAEFDNP
560 570 580 590 600
NIVKLLGVCA VGKPMCLLFE YMAYGDLNEF LRSMSPHTVC SLSHSDLSMR
610 620 630 640 650
AQVSSPGPPP LSCAEQLCIA RQVAAGMAYL SERKFVHRDL ATRNCLVGEN
660 670 680 690 700
MVVKIADFGL SRNIYSADYY KANENDAIPI RWMPPESIFY NRYTTESDVW
710 720 730 740 750
AYGVVLWEIF SYGLQPYYGM AHEEVIYYVR DGNILSCPEN CPVELYNLMR
760 770 780
LCWSKLPADR PSFTSIHRIL ERMCERAEGT VSV
Length:783
Mass (Da):87,530
Last modified:March 28, 2018 - v1
Checksum:i47D39701863D9BF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AQIA01023823 Genomic DNA No translation available.
AQIA01023824 Genomic DNA No translation available.
AQIA01023825 Genomic DNA No translation available.
RefSeqiXP_005581151.1, XM_005581094.2

Genome annotation databases

EnsembliENSMFAT00000065910; ENSMFAP00000015383; ENSMFAG00000030822
GeneIDi102127677

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AQIA01023823 Genomic DNA No translation available.
AQIA01023824 Genomic DNA No translation available.
AQIA01023825 Genomic DNA No translation available.
RefSeqiXP_005581151.1, XM_005581094.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMFAT00000065910; ENSMFAP00000015383; ENSMFAG00000030822
GeneIDi102127677

Organism-specific databases

CTDi4593

Phylogenomic databases

GeneTreeiENSGT00760000118818

Family and domain databases

Gene3Di1.10.2000.10, 1 hit
2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR036790 Frizzled_dom_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2K5USG5_MACFA
AccessioniPrimary (citable) accession number: A0A2K5USG5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: October 10, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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