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Protein

Bestrophin

Gene

BEST4

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Forms calcium-sensitive chloride channels. Permeable to bicarbonate.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionChloride channelUniRule annotation, Ion channel
Biological processIon transport, Transport
LigandChloride

Names & Taxonomyi

Protein namesi
Recommended name:
BestrophinUniRule annotation
Gene namesi
Name:BEST4Imported
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)Imported
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei36 – 54HelicalUniRule annotationAdd BLAST19
Transmembranei75 – 94HelicalUniRule annotationAdd BLAST20

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the bestrophin family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000002997
KOiK13881

Family and domain databases

InterProiView protein in InterPro
IPR000615 Bestrophin
IPR021134 Bestrophin/UPF0187
PANTHERiPTHR10736 PTHR10736, 1 hit
PfamiView protein in Pfam
PF01062 Bestrophin, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2K5UJ64-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVSYTLKVA EARFGGFSGL LLRWRGSIYK LLYKEFLLFG ALYAVLSITY
60 70 80 90 100
RLLLTQEQKH VYAQVARYCN RSADLIPLSF VLGFYVTLVV NRWWSQYTSI
110 120 130 140 150
PLPDQLMCVI SASVHGVDQR GRLLRRTLIR YANLASVLVL RSVSTRVLKR
160 170 180 190 200
FPTMEHVVDA GFMSQEERKK FESLKSDFNK YWVPCVWFTN LAAQARRDGR
210 220 230 240 250
IRDDIALCLL LEELNKYRAK CSMLFHYDWI SIPLVYTQVV TIAVYSFFAL
260 270 280 290 300
SLVGRQFVEP EAGAAKPQKL LKPDQEPAPA LGDPDMYVPL TTLLQFFFYA
310 320 330 340 350
GWLKVAEQII NPFGEDDDDF ETNQLIDRNL QVSLLSVDEM YQNLPPAEKD
360 370 380 390 400
QYWDEDQPQP PYTVATAAES LRPSFLGSTF NLRMSDDPEQ SLQVEASPGP
410 420 430 440 450
GRPAPAAQTP LLGRFLGVGA PSPAISLRNF GRARGTPRPP HLLRFRAEEG
460 470
GDPEAAARIE EETAESGDEA LEP
Length:473
Mass (Da):53,497
Last modified:March 28, 2018 - v1
Checksum:i15EF9307F61733BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AQIA01004393 Genomic DNA No translation available.
RefSeqiXP_005543627.1, XM_005543570.1
XP_005543629.1, XM_005543572.2

Genome annotation databases

EnsembliENSMFAT00000058254; ENSMFAP00000012437; ENSMFAG00000024339
GeneIDi102133599
KEGGimcf:102133599

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AQIA01004393 Genomic DNA No translation available.
RefSeqiXP_005543627.1, XM_005543570.1
XP_005543629.1, XM_005543572.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMFAT00000058254; ENSMFAP00000012437; ENSMFAG00000024339
GeneIDi102133599
KEGGimcf:102133599

Organism-specific databases

CTDi266675

Phylogenomic databases

GeneTreeiENSGT00390000002997
KOiK13881

Family and domain databases

InterProiView protein in InterPro
IPR000615 Bestrophin
IPR021134 Bestrophin/UPF0187
PANTHERiPTHR10736 PTHR10736, 1 hit
PfamiView protein in Pfam
PF01062 Bestrophin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2K5UJ64_MACFA
AccessioniPrimary (citable) accession number: A0A2K5UJ64
Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: July 18, 2018
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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