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Entry version 22 (02 Jun 2021)
Sequence version 2 (02 Jun 2021)
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Protein
Submitted name:

RB transcriptional corepressor 1

Gene

RB1

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressorARBA annotation
Biological processCell cycleARBA annotation, Transcription, Transcription regulationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
RB transcriptional corepressor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RB1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9541 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000233100 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A2K5UC26

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the retinoblastoma protein (RB) family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183202

Identification of Orthologs from Complete Genome Data

More...
OMAi
VPGGNIY

Database of Orthologous Groups

More...
OrthoDBi
113612at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00043, CYCLIN, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR002720, RB_A
IPR002719, RB_B
IPR015030, RB_C
IPR028309, RB_fam
IPR024599, RB_N

The PANTHER Classification System

More...
PANTHERi
PTHR13742, PTHR13742, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11934, DUF3452, 1 hit
PF01858, RB_A, 1 hit
PF01857, RB_B, 1 hit
PF08934, Rb_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00385, CYCLIN, 1 hit
SM01367, DUF3452, 1 hit
SM01368, RB_A, 1 hit
SM01369, Rb_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47954, SSF47954, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A2K5UC26-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPKTPKTAA AAAAAAAEPP APPPPPPPEE DPEQDSGPED LPLVRLEFEE
60 70 80 90 100
TEEPDFTALC QKLKIPDHVR ERAWLTWEKV SSVDGVLGGY IQKKKELWGI
110 120 130 140 150
CIFIAAVDLD EMPFTFTELQ KNIEISVHKF FNLLKEIDTS TKVDNAMSRL
160 170 180 190 200
LKKYDVLFAL FSKLERTCEL IYLTQPSSSI STEINSTLVL KVSWITFLLA
210 220 230 240 250
KGEVLQMEDD LVISFQLMLC VLDYFIKLSP PVLLKEPYKT AVIPINGSPR
260 270 280 290 300
TPRRGQNRSA RIAKQLENDT RIIEVLCKEH ECNIDEVKNV YFKNFIPFMN
310 320 330 340 350
SLGLVTSNGL PEVESLSKRY EEIYLKNKDL DARLFLDHDK TLQTDSIDSF
360 370 380 390 400
ETQRTPRKSN LDEEVNVIPP HTPVRTVMNT IQQLMMILNS ASDQPSENLI
410 420 430 440 450
SYFNNCTVNP KESILKRVKD IGYIFKEKFA KAVGQGCVEI GSQRYKLGVR
460 470 480 490 500
LYYRVMESML KSEEERLSIQ NFSKLLNDNI FHMSLLACAL EVVMATYSRS
510 520 530 540 550
TSQNLDSGTD LSFPWILNVL NLKAFDFYKV IESFIKAEGN LTREMIKHLE
560 570 580 590 600
RCEHRIMESL AWLSDSPLFD LIKQSKDREG PTDHFESACP LNLPLQNNHT
610 620 630 640 650
AADMYLSPVR SPKKKGSTTR VNSTANAETQ ATSAFQTQKP LKSTSLSLFY
660 670 680 690 700
KKVYRLAYLR LNTLCERLLS EHPELEHIIW TLFQHTLQNE YELMRDRHLD
710 720 730 740 750
QIMMCSMYGI CKVKNIDLKF KIIVTAYKDL PHAVQETFKR VLIKEEEYDS
760 770 780 790 800
IIVFYNSVFM QRLKTNILQY ASTRPPTLSP IPHIPRSPYK FPSSPLRIPG
810 820 830 840 850
GNIYISPLKS PYKISEGLPT PTKMTPKILV SIGESFGTSE KFQKINQMVC
860 870 880 890 900
NSDRVLKRSA EGSNPPKPLK KLRFDIEGSD EADGSKHLPG ESKFQQKLAE
910 920
MTSTRTRMQK QKMNDSMDTS NKEEK
Length:925
Mass (Da):105,717
Last modified:June 2, 2021 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC7A03C2044907136
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A7N9C7Q4A0A7N9C7Q4_MACFA
RB transcriptional corepressor 1
RB1
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_005585892.1, XM_005585835.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMFAT00000037550; ENSMFAP00000009916; ENSMFAG00000004544

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
102145859

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mcf:102145859

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_005585892.1, XM_005585835.2

3D structure databases

SMRiA0A2K5UC26
ModBaseiSearch...

Genome annotation databases

EnsembliENSMFAT00000037550; ENSMFAP00000009916; ENSMFAG00000004544
GeneIDi102145859
KEGGimcf:102145859

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5925

Phylogenomic databases

GeneTreeiENSGT00950000183202
OMAiVPGGNIY
OrthoDBi113612at2759

Family and domain databases

CDDicd00043, CYCLIN, 1 hit
InterProiView protein in InterPro
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR002720, RB_A
IPR002719, RB_B
IPR015030, RB_C
IPR028309, RB_fam
IPR024599, RB_N
PANTHERiPTHR13742, PTHR13742, 1 hit
PfamiView protein in Pfam
PF11934, DUF3452, 1 hit
PF01858, RB_A, 1 hit
PF01857, RB_B, 1 hit
PF08934, Rb_C, 1 hit
SMARTiView protein in SMART
SM00385, CYCLIN, 1 hit
SM01367, DUF3452, 1 hit
SM01368, RB_A, 1 hit
SM01369, Rb_C, 1 hit
SUPFAMiSSF47954, SSF47954, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K5UC26_MACFA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K5UC26
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: June 2, 2021
Last modified: June 2, 2021
This is version 22 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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