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Entry version 10 (10 Apr 2019)
Sequence version 1 (28 Mar 2018)
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Protein
Submitted name:

Uncharacterized protein

Gene

SLC12A2

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC12A2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9541 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei283 – 304HelicalSequence analysisAdd BLAST22
Transmembranei316 – 345HelicalSequence analysisAdd BLAST30
Transmembranei365 – 386HelicalSequence analysisAdd BLAST22
Transmembranei407 – 426HelicalSequence analysisAdd BLAST20
Transmembranei432 – 455HelicalSequence analysisAdd BLAST24
Transmembranei485 – 507HelicalSequence analysisAdd BLAST23
Transmembranei519 – 543HelicalSequence analysisAdd BLAST25
Transmembranei653 – 673HelicalSequence analysisAdd BLAST21
Transmembranei679 – 697HelicalSequence analysisAdd BLAST19
Transmembranei709 – 728HelicalSequence analysisAdd BLAST20
Transmembranei734 – 749HelicalSequence analysisAdd BLAST16

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini200 – 253AA_permease_NInterPro annotationAdd BLAST54
Domaini288 – 790AA_permeaseInterPro annotationAdd BLAST503
Domaini799 – 1210SLC12InterPro annotationAdd BLAST412

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155742

KEGG Orthology (KO)

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KOi
K10951

Database of Orthologous Groups

More...
OrthoDBi
254933at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR013612 AA_permease_N
IPR002443 Na/K/Cl_cotranspt
IPR002444 NKCC1
IPR018491 SLC12_C
IPR004842 SLC12A_fam

The PANTHER Classification System

More...
PANTHERi
PTHR11827:SF58 PTHR11827:SF58, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00324 AA_permease, 1 hit
PF08403 AA_permease_N, 1 hit
PF03522 SLC12, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01207 NAKCLTRNSPRT
PR01208 NAKCLTRSPRT1

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00930 2a30, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2K5U724-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPVPTAPSS GAPGLAGVGE TPPAAALAAA RVELPGTAVP SVPEDAAPAS
60 70 80 90 100
RDGGGVRGEG AAAAGDGLGR PLGPTPSQSR FQVDLVSENA GRAAAAAAAA
110 120 130 140 150
AAAAAAGAGA GAKQTPADGE GGGESGPAKG SEEAKGRFRV NFVDPAASSS
160 170 180 190 200
AEDSLSDAAG VGGDGPNVSF QNGGDTVLSE GSSLHSGGGG SGHHQHYYYD
210 220 230 240 250
THTNTYYLRT FGHNTMDAVP RIDHYRHTAA QLGEKLLRPS LAELHDELEK
260 270 280 290 300
EPFEDGFANG EESTPTRDAV VTYTAESKGV VKFGWIKGVL VRCMLNIWGV
310 320 330 340 350
MLFIRLSWIV GQAGIGLSVL VIMMATVVTT ITGLSTSAIA TNGFVRGGGA
360 370 380 390 400
YYLISRSLGP EFGGAIGLIF AFANAVAVAM YVVGFAETVV ELLKEHSILM
410 420 430 440 450
IDEINDIRII GAITVVILLG ISVAGMEWEA KAQIVLLVIL LLAIGDFVIG
460 470 480 490 500
TFIPLESKKP KGFFGYKSEI FNENFGPDFR EEETFFSVFA IFFPAATGIL
510 520 530 540 550
AGANISGDLA DPQSAIPKGT LLAILITTLV YVGIAVSVGS CVVRDATGNV
560 570 580 590 600
NDTIVTELTN CTSAACKLNF DFSSCESSPC SYGLMNNFQV MSMVSGFTPL
610 620 630 640 650
ISAGIFSATL SSALASLVSA PKIFQALCKD NIYPAFQMFA KGYGKNNEPL
660 670 680 690 700
RGYILTFLIA LGFILIAELN VIAPIISNFF LASYALINFS VFHASLAKSP
710 720 730 740 750
GWRPAFKYYN MWISLLGAIL CCIVMFVINW WAALLTYVIV LGLYIYVTYK
760 770 780 790 800
KPDVNWGSST QALTYLNALQ HSIRLSGVED HVKNFRPQCL VMTGAPNSRP
810 820 830 840 850
ALLHLVHDFT KNVGLMICGH VHMGPRRQAM KEMSIDQAKY QRWLIKNKMK
860 870 880 890 900
AFYAPVHADD LREGAQYLMQ AAGLGRMKPN TLVLGFKKDW LQADMRDVDM
910 920 930 940 950
YINLFHDAFD IQYGVVVIRL KEGLDISHLQ GQEELLSSQE KSPGTKDVVV
960 970 980 990 1000
SVEYSKKSDL DTSKPLSEKP VTHKVEEEDG KTATQPLLKK ESKGPIVPLN
1010 1020 1030 1040 1050
VADQKLLEAS TQFQKKQGKN TIDVWWLFDD GGLTLLIPYL LTTKKKWKDC
1060 1070 1080 1090 1100
KIRVFIGGKI NRIDHDRRAM ATLLSKFRID FSDIMVLGDI NTKPKKENII
1110 1120 1130 1140 1150
AFEEMIEPYR LHEDDKEQDI ADKMKEDEPW RITDNELELY KTKTYRQIRL
1160 1170 1180 1190 1200
NELLKEHSST ANIIVMSLPV ARKGAVSSAL YMAWLEALSK DLPPILLVRG
1210
NHQSVLTFYS
Length:1,210
Mass (Da):131,034
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2ACE09768CE81791
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AQIA01060411 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_005557731.1, XM_005557674.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mfa.8937

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMFAT00000021898; ENSMFAP00000008154; ENSMFAG00000001384

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
101865866

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mcf:101865866

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AQIA01060411 Genomic DNA No translation available.
RefSeqiXP_005557731.1, XM_005557674.2
UniGeneiMfa.8937

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMFAT00000021898; ENSMFAP00000008154; ENSMFAG00000001384
GeneIDi101865866
KEGGimcf:101865866

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6558

Phylogenomic databases

GeneTreeiENSGT00940000155742
KOiK10951
OrthoDBi254933at2759

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR013612 AA_permease_N
IPR002443 Na/K/Cl_cotranspt
IPR002444 NKCC1
IPR018491 SLC12_C
IPR004842 SLC12A_fam
PANTHERiPTHR11827:SF58 PTHR11827:SF58, 1 hit
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
PF08403 AA_permease_N, 1 hit
PF03522 SLC12, 1 hit
PRINTSiPR01207 NAKCLTRNSPRT
PR01208 NAKCLTRSPRT1
TIGRFAMsiTIGR00930 2a30, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K5U724_MACFA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K5U724
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: April 10, 2019
This is version 10 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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