Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 6 (10 Apr 2019)
Sequence version 1 (28 Mar 2018)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein
Submitted name:

CDK5 regulatory subunit-associated protein 2

Gene

CDK5RAP2

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CDK5 regulatory subunit-associated protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDK5RAP2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9541 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini61 – 131Cnn_1NInterPro annotationAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili61 – 81Sequence analysisAdd BLAST21
Coiled coili104 – 131Sequence analysisAdd BLAST28
Coiled coili143 – 163Sequence analysisAdd BLAST21
Coiled coili217 – 244Sequence analysisAdd BLAST28
Coiled coili268 – 313Sequence analysisAdd BLAST46
Coiled coili321 – 362Sequence analysisAdd BLAST42
Coiled coili367 – 387Sequence analysisAdd BLAST21
Coiled coili395 – 486Sequence analysisAdd BLAST92
Coiled coili541 – 561Sequence analysisAdd BLAST21
Coiled coili578 – 622Sequence analysisAdd BLAST45
Coiled coili1197 – 1234Sequence analysisAdd BLAST38
Coiled coili1296 – 1319Sequence analysisAdd BLAST24
Coiled coili1396 – 1430Sequence analysisAdd BLAST35
Coiled coili1446 – 1466Sequence analysisAdd BLAST21
Coiled coili1478 – 1526Sequence analysisAdd BLAST49
Coiled coili1555 – 1578Sequence analysisAdd BLAST24

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183190

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012943 Cnn_1N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07989 Cnn_1N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2K5U287-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
FLSSILEKSS SHLLSHVFSP SGLVPNVPDD LDGINPDARL GNGVLSNVSE
60 70 80 90 100
ETVSPTRARN MKDFENQITE LKKENFNLKL RIYFLEERMQ QEFHGPAEHI
110 120 130 140 150
YKTNIELKVE VESLKRELQE RERLLIKASK AVESLAEAGG SEIQRVKEDA
160 170 180 190 200
RKKVQQVEDL LTKRILLLEK DVKAAQAELE KAFAGTETEK ALRLSLESKL
210 220 230 240 250
SEMKKMHKGD LAMALVLDEK DRLIEELKLS LKSKEALIQC LKEEKAQMAS
260 270 280 290 300
PDENVSSGEL RGLCAAPREE KERETEAAQM EHQKERNSFE ERIQALEEDL
310 320 330 340 350
REKEREIATE KKNSLKRDKA IQGLTMALKS KEKKVEELNS EIEKLSAAFA
360 370 380 390 400
KAREALQKAQ TQEFQGSENY EAALSGKEAL LAELRSQNLT KSAENHRLRR
410 420 430 440 450
SIKKITQELS DLQQERERLE KDLEEAHREK SRGDCTIRDL RNEVEKLRNE
460 470 480 490 500
VNEREKAMEN RYKNLLSESS KKLHNQEQVI KHLTERTNHK DMLLQKFNEK
510 520 530 540 550
DLEVIQQNHY LMTAEDLELR SEGLITEKCP SQQSPGSKTI FSKEEKQSSD
560 570 580 590 600
YQELIQVLKK EQDIYTHLVK SLQESDSINN LQAELNNIFA LRKQLERDVL
610 620 630 640 650
SYQNLRKTLE EQISEIRRRE EESFSFYSDQ TSYLSICLEE NNRFQVEHFS
660 670 680 690 700
QEELKKKVSD LIQLVKELYT DNQHLKKTIF DLSCMGFQGN GFPDRLVSTE
710 720 730 740 750
QTELMASKED EDTIKIGEDD ENNFLSDQHL QQSNEITKDL SKGGCKNGYL
760 770 780 790 800
RHTEPKILES DGAHTPGCLE EGVFINLLAP LFNEKATLLL ESRPDLLKVV
810 820 830 840 850
RELLLGHLCL AEQDVSGEHL GGKTEKTPKQ KGELVHFVQT NSFSKPHDEL
860 870 880 890 900
KLSCEAQLVK AGEVPKVELK DASVQTVATE GDLLRTKHEA VREAWEEKPI
910 920 930 940 950
NTALRAEHRP ENLPGVPGWQ AALLSLPGGT NREAKKSRLP ILIKPSQSLR
960 970 980 990 1000
NTYRLPATQE VVTQLQSQIL ELQGELKEFK TCNKQLHQKL ILAEAMMEGR
1010 1020 1030 1040 1050
PTPDKMLLNA QPPVGAAYQD NPGEQKGIKT TSSAWRDKEM DSDQQTSYEI
1060 1070 1080 1090 1100
GSEICPPDDL ASLPSCKENP EDVLSPTSVA TYLSSKSQPS AKVSVMGTDQ
1110 1120 1130 1140 1150
SESTDTSNET EYLKQKIHDL ETELEGYQNF IFQLQKHSQC SEAIITVLCG
1160 1170 1180 1190 1200
TEGAQDGLSK PKSSSDEEEM TFSGLHQVRY VKHMKILHPL APEMIDGRML
1210 1220 1230 1240 1250
ENLKQQLEEQ EYELQKEQNL NMELFSEIHN LQNKFRDLSP SRYDSLVQSQ
1260 1270 1280 1290 1300
ARELSLQRQQ IKDGHGICVI SRQHMNTMIK AFEELLQASD VDYCVAEGFQ
1310 1320 1330 1340 1350
EQLNQCAELL EKLEKLFLNG KSVGVEMNTQ NELMERIEED NLTYQHLLPE
1360 1370 1380 1390 1400
SPEPSASHVL SDYETSEKSF FSQDQKQDNE TEKTSVMVNN FSQDLLMEHI
1410 1420 1430 1440 1450
QEIRTLRKRL EESIKTNDKL RKQLERQGSE FDQGSTNIFA SGSELHSSLT
1460 1470 1480 1490 1500
SEIQFLRKQN QALNAMLIKA SIDKQKENDK LRESLSRKTA SLEHLQREYA
1510 1520 1530 1540 1550
SVKEENERLQ KEGSEKERHN QQLIQEVCRS GQELSRVQEE VKLRQQLLSQ
1560 1570 1580 1590 1600
NDKLLQSLRV ELKAYEKLDE EHRRLREASG EGWKGQDPFR DLHSLLMEIQ
1610 1620 1630 1640 1650
ALRLQLERSI ETSSTLQSSL EEQLARGAEK AQEGALTLAI QALSIPEVPL
1660 1670 1680 1690 1700
QPDKHDGDKD PMESDNSFDL FDSSQAVTPK SVSETLPLSE NDTDSLSCDS
1710 1720 1730 1740 1750
GSSATSTPCV SRLVAGHRLW ASKNGRHVLG LIEDYEALLK QIGQGQRLLA
1760 1770 1780 1790 1800
EMDIQTQEAP SYTSQELGTK GPHPAPLSKF VSSVSTAKLT LEEASRRLKL
1810 1820 1830 1840 1850
LWRVSVPEDG QCPLHCEQIG EMKAEVTKLH KKLFEQEKKL QNTMKLLQLS
1860 1870 1880 1890 1900
KRQEKVIFDQ LVVTHKILRK ARGNLEVCPL SLHCRPVEGW EGCRARKDLL
1910 1920
KNEGAGGTRG HVLLRELCVS ASSA
Length:1,924
Mass (Da):218,975
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1ABEBBFB3FCDE229
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AQIA01023580 Genomic DNA No translation available.
AQIA01023581 Genomic DNA No translation available.
AQIA01023582 Genomic DNA No translation available.
AQIA01023583 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMFAT00000025144; ENSMFAP00000006458; ENSMFAG00000039120

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AQIA01023580 Genomic DNA No translation available.
AQIA01023581 Genomic DNA No translation available.
AQIA01023582 Genomic DNA No translation available.
AQIA01023583 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMFAT00000025144; ENSMFAP00000006458; ENSMFAG00000039120

Phylogenomic databases

GeneTreeiENSGT00950000183190

Family and domain databases

InterProiView protein in InterPro
IPR012943 Cnn_1N
PfamiView protein in Pfam
PF07989 Cnn_1N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K5U287_MACFA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K5U287
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: April 10, 2019
This is version 6 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again