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Protein

DNA polymerase

Gene

POLA1

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, DNA-directed DNA polymeraseUniRule annotation, Nucleotidyltransferase, Transferase
Biological processDNA replicationUniRule annotation
Ligand4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymeraseUniRule annotation (EC:2.7.7.7UniRule annotation)
Gene namesi
Name:POLA1Imported
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)Imported
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 99DNA_pol_alpha_NInterPro annotationAdd BLAST62
Domaini374 – 713DNA_pol_B_exo1InterPro annotationAdd BLAST340
Domaini771 – 1230DNA_pol_BInterPro annotationAdd BLAST460
Domaini1269 – 1458zf-DNA_PolInterPro annotationAdd BLAST190

Sequence similaritiesi

Belongs to the DNA polymerase type-B family.UniRule annotation

Keywords - Domaini

Zinc-fingerUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000074891
KOiK02320

Family and domain databases

Gene3Di1.10.3200.20, 1 hit
3.30.420.10, 1 hit
3.90.1600.10, 1 hit
InterProiView protein in InterPro
IPR006172 DNA-dir_DNA_pol_B
IPR017964 DNA-dir_DNA_pol_B_CS
IPR006133 DNA-dir_DNA_pol_B_exonuc
IPR006134 DNA-dir_DNA_pol_B_multi_dom
IPR024647 DNA_pol_a_cat_su_N
IPR023211 DNA_pol_palm_dom_sf
IPR038256 Pol_alpha_znc_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR015088 Znf_DNA-dir_DNA_pol_B_alpha
PfamiView protein in Pfam
PF12254 DNA_pol_alpha_N, 1 hit
PF00136 DNA_pol_B, 1 hit
PF03104 DNA_pol_B_exo1, 1 hit
PF08996 zf-DNA_Pol, 1 hit
PRINTSiPR00106 DNAPOLB
SMARTiView protein in SMART
SM00486 POLBc, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS00116 DNA_POLYMERASE_B, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2K5TTK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVHGDGCE IGASDSGSFV ASRARREKKS KKGRQEALER LKKAKAGEKY
60 70 80 90 100
KYEVEDFTGV YEEVDEEQYS KLVQARQDDD WIVDDDGIGY VEDGREIFDD
110 120 130 140 150
DLEDDALDAG EKGKDGKARN KDKRNVKKPA VTKPNNIKSM FIACAGKKTA
160 170 180 190 200
DKAVDLSKDD LLGDILQDLN TETPQITPPP VTILKKKRSI GASPNPFSVH
210 220 230 240 250
TSTAVPSGKI ASPVSRKEPP LTPIPLKRAE FAGEPIQVES TEEEQESGAM
260 270 280 290 300
EFEDGDFDEP METEEVDLEP MAAKAWDQES EPAEEVKQEA DSGKGTMSDL
310 320 330 340 350
GRFLPDVSCW DIDQEGDSSF SVQEVQVDSS QLPLVKGADE EQVFHFYWLD
360 370 380 390 400
AYEDQYNQPG VVFLFGKVWI ESAETHVSCC VMVKNIERTL YFLPREMKID
410 420 430 440 450
LNTGKETGTP VSMKDVYEEF DEKIATKYKI MKFKSKPVEK NYAFEIPDVP
460 470 480 490 500
EKSEYLEVKY SAEIPQLPQD LKGETFSHVF GTNTSSLELF LMNRKIKGPC
510 520 530 540 550
WLEVKSPQLL NQPISWCKVE AMALKPDLVN VIKDVSPPPL VVMAFSMKTM
560 570 580 590 600
QNAKNHQNEI IAVAALVHHS FALDKAAPKP PFQSHFCVVS KPKDCIFPYA
610 620 630 640 650
FKEVIEKKNV KVEVAATERT LLGFFLAKVH KIDPDIIVGH NIYGFELEVL
660 670 680 690 700
LQRINVCKAP HWSKIGRLKR SNMPKLGGRS GFGERNATCG RMICDVEISA
710 720 730 740 750
KELIRCKSYH LSELVQQILK TERVVIPTED IRNMYSESSQ LLYLLEHTWK
760 770 780 790 800
DAKFILQIMC ELNVLPLALQ ITNIAGNIMS RTLMGGRSER NEFLLLHAFY
810 820 830 840 850
ENNYIVPDKQ IFRKPQQKLG DEDEEIDGDT NKYKKGRKKA AYAGGLVLDP
860 870 880 890 900
KVGFYDKFIL LLDFNSLYPS IIQEFNICFT TVQRVASEAQ KVTEDGEQEQ
910 920 930 940 950
IPELPDPSLE MGILPREIRK LVERRKQVKQ LMKQQDLNPD LILQYDIRQK
960 970 980 990 1000
ALKLTANSMY GCLGFSYSRF YAKPLAALVT YKGREILMHT KEMVQKMNLE
1010 1020 1030 1040 1050
VIYGDTDSIM INTNSTNLEE VFKLGNKVKS EVNKLYKLLE IDIDGIFKSL
1060 1070 1080 1090 1100
LLLKKKKYAA LVVEPTSDGN YATKQELKGL DIVRRDWCDL AKDTGNFVIG
1110 1120 1130 1140 1150
QILSDQSRDT IVENIQKRLI EIGENVLNGS VPVSQFEINK ALTKDPQDYP
1160 1170 1180 1190 1200
DKKSLPHVHV ALWINSQGGR KVKAGDTVSY IICQDGSNLT ASQRAYAPEQ
1210 1220 1230 1240 1250
LQKQDNLTID TQYYLAQQIH PVVARICEPI DGIDAVLIAT WLGLDPTQFR
1260 1270 1280 1290 1300
VHHYHKDEEN DALLGGPAQL TDEEKYRDCE RFKCPCPTCG TENIYDNVFD
1310 1320 1330 1340 1350
GSGTDMEPSL YRCSNIDCKA SPLTFTVQLS NKLIMDIRRF IKKYYDGWLI
1360 1370 1380 1390 1400
CEEPTCGNRT RHLPLQFSRT GPLCPACMKA TLRPEYSDKS LYTQLCFYRY
1410 1420 1430 1440 1450
IFDAECALEK LTTDHEKDKL KKQFFTPRVL QDYRKLKNTA EQFLSRSGYS
1460
EVNLSKLFAG CAVKS
Length:1,465
Mass (Da):166,058
Last modified:March 28, 2018 - v1
Checksum:i4D5163D577EA5084
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AQIA01083792 Genomic DNA No translation available.
AQIA01083793 Genomic DNA No translation available.
AQIA01083794 Genomic DNA No translation available.
AQIA01083795 Genomic DNA No translation available.
AQIA01083796 Genomic DNA No translation available.
AQIA01083797 Genomic DNA No translation available.
AQIA01083798 Genomic DNA No translation available.
AQIA01083799 Genomic DNA No translation available.
AQIA01083800 Genomic DNA No translation available.
AQIA01083801 Genomic DNA No translation available.
RefSeqiXP_005593254.1, XM_005593197.2

Genome annotation databases

EnsembliENSMFAT00000022037; ENSMFAP00000003377; ENSMFAG00000001338
GeneIDi102121255
KEGGimcf:102121255

Similar proteinsi

Entry informationi

Entry nameiA0A2K5TTK6_MACFA
AccessioniPrimary (citable) accession number: A0A2K5TTK6
Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: July 18, 2018
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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