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Protein

Sodium channel protein

Gene

SCN5A

Organism
Cebus capucinus imitator
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
Name:SCN5AImported
OrganismiCebus capucinus imitatorImported
Taxonomic identifieri1737458 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCebinaeCebus
Proteomesi
  • UP000233040 Componenti: Whole Genome Shotgun Assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei127 – 149HelicalUniRule annotationAdd BLAST23
Transmembranei253 – 272HelicalUniRule annotationAdd BLAST20
Transmembranei388 – 416HelicalUniRule annotationAdd BLAST29
Transmembranei721 – 739HelicalUniRule annotationAdd BLAST19
Transmembranei751 – 769HelicalUniRule annotationAdd BLAST19
Transmembranei781 – 798HelicalUniRule annotationAdd BLAST18
Transmembranei838 – 861HelicalUniRule annotationAdd BLAST24
Transmembranei881 – 902HelicalUniRule annotationAdd BLAST22
Transmembranei914 – 939HelicalUniRule annotationAdd BLAST26
Transmembranei1205 – 1224HelicalUniRule annotationAdd BLAST20
Transmembranei1245 – 1261HelicalUniRule annotationAdd BLAST17
Transmembranei1273 – 1294HelicalUniRule annotationAdd BLAST22
Transmembranei1322 – 1348HelicalUniRule annotationAdd BLAST27
Transmembranei1444 – 1470HelicalUniRule annotationAdd BLAST27
Transmembranei1529 – 1547HelicalUniRule annotationAdd BLAST19
Transmembranei1559 – 1577HelicalUniRule annotationAdd BLAST19
Transmembranei1589 – 1609HelicalUniRule annotationAdd BLAST21
Transmembranei1646 – 1674HelicalUniRule annotationAdd BLAST29
Transmembranei1749 – 1772HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 422Ion_transInterPro annotationAdd BLAST293
Domaini479 – 667Na_trans_cytoplInterPro annotationAdd BLAST189
Domaini718 – 943Ion_transInterPro annotationAdd BLAST226
Domaini953 – 1200Na_trans_assocInterPro annotationAdd BLAST248
Domaini1204 – 1479Ion_transInterPro annotationAdd BLAST276
Domaini1528 – 1782Ion_transInterPro annotationAdd BLAST255

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili413 – 451Sequence analysisAdd BLAST39

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00830000128242

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR008053 Na_channel_a5su
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR024583 Na_trans_cytopl
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PF11933 Na_trans_cytopl, 1 hit
PRINTSiPR00170 NACHANNEL
PR01666 NACHANNEL5

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A2K5Q6Y6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANLLLPRGT SGFHRFTRES LAAIEKRMAE KQARGSAASQ ESRDGLPEEE
60 70 80 90 100
APRPQLDLQA SKKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK
110 120 130 140 150
TIFRFSATNA LYVLSPFHPI RRVAVKILVH SFFSMLIMCT ILTNCVFMAQ
160 170 180 190 200
HDPPPWTKYV EYTFTAIYTF ESLVKILARG FCLHAFTFLR DPWNWLDFSV
210 220 230 240 250
IIMAYVSENI KLGNLSALRT FRVLRALKTI SVIPGLKTIV GALIQSVKKL
260 270 280 290 300
ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRDFTTLNGT NGSVEADGSV
310 320 330 340 350
WESLDLYLSD PENYLLKNGT SDVLLCGNSS DAGTCPKGYR CLKAGENPDH
360 370 380 390 400
GYTSFDSFAW AFLALFRLMT QDCWERLYQQ TLRSAGKIYM IFFMLVIFLG
410 420 430 440 450
SFYLVNLILA VVAMAYEEQN QATIAETEEK EKRFQEAMEM LKKEHEALTI
460 470 480 490 500
RGVDTVSRSS LEMSPLAPVT THERRSKGRK RMSSGTEECG EDRLPKSDSE
510 520 530 540 550
DGPRAVNRLS LTHGLSRTSM KPRSSRGSIF TFRRRDLGSE TDFADDENST
560 570 580 590 600
AGESESHHTS LLVPWPLRQT GAQGQPSPGT SAPGHALNGK KNSTVDCNGV
610 620 630 640 650
VSLLGAGDPE ATSPGSHLLR PVMLEHPLDT TTPSEEPGGP QMLTPQAPCV
660 670 680 690 700
DGFEEPEARQ RALSAVSVLT SALEELEESH RKCPPCWNRF AQRYLIWECC
710 720 730 740 750
PLWMSIKQGV KFVVMDPFTD LTITMCIVLN TLFMALEHYN MTSEFEDMLQ
760 770 780 790 800
VGNLVFTGIF TAEMTFKIIA LDPYYYFQQG WNIFDSIIVI LSLMELGLSR
810 820 830 840 850
MSNLSVLRSF RLLRVFKLAK SWPTLNTLIK IIGNSVGALG NLTLVLAIIV
860 870 880 890 900
FIFAVVGMQL FGKNYSELRH SDSGLLPRWH MMDFFHAFLI IFRILCGEWI
910 920 930 940 950
ETMWDCMEVS GQSLCLLVFL LVMVIGNLVV LNLFLALLLS SFSADNLTAP
960 970 980 990 1000
DEDRELNNLQ LALARIQRGL RFIKRTTWDF CCGLLRQRPQ KPAALAARGQ
1010 1020 1030 1040 1050
LPSCIATPHS LPPPETEKAP PARKETRFEE GERPGQGTPR YPETVCVPIA
1060 1070 1080 1090 1100
VAESDTDDQE EDEENSLGTE EESSKQQESQ PVSGGPEAPP DSRTWSQVSA
1110 1120 1130 1140 1150
TASSEAEASA SQADWQQQRK VEPRAPGCSE TPEDSYSEGS TADMTNTAEL
1160 1170 1180 1190 1200
LEQIPDLGQD VKDPEDCFTE GCVRRCPCCA VDTTQAPGKV WWQLRKTCYR
1210 1220 1230 1240 1250
IVEHSWFETF IIFMILLSSG ALAFEDIYLE ERKTIKVLLE YADKMFTYVF
1260 1270 1280 1290 1300
VLEMLLKWVA YGFKKYFTNA WCWLDFLIVD VSLISLVANT LGFAEMGPIK
1310 1320 1330 1340 1350
SLRTLRALRP LRALSRFEGM RVVVNALVGA IPSIMNVLLV CLIFWLIFSI
1360 1370 1380 1390 1400
MGVNLFAGKF GRCINQTEGD LPLNYTIVNN KSQCESLNMT GELYWTKVKV
1410 1420 1430 1440 1450
NFDNVGAGYL ALLQVATFKG WMDIMYAAVD SRGYEEQPQW EYNLYMYIYF
1460 1470 1480 1490 1500
VVFIIFGSFF TLNLFIGVII DNFNQQKKKL GGQDIFMTEE QKKYYNAMKK
1510 1520 1530 1540 1550
LGSKKPQKPI PRPLNKYQGF IFDIVTKQAF DVTIMFLICL NMVTMMVETD
1560 1570 1580 1590 1600
DQSPEKVNIL TKINLLFVAI FTGECIFKMA ALRHYYFTNS WNIFDFVVVI
1610 1620 1630 1640 1650
LSIVGTVLSD IIQKYFFSPT LFRVIRLARI GRILRLIRGA KGIRTLLFAL
1660 1670 1680 1690 1700
MMSLPALFNI GLLLFLVMFI YSIFGMANFP HVKWEAGIDD MFNFQTFANS
1710 1720 1730 1740 1750
MLCLFQITTS AGWDGLLSPI LNTGPPYCDP NLLNSNGSRG DCGSPAVGIL
1760 1770 1780 1790 1800
FFTTYIIISF LIVVNMYIAI ILENFSVATE ESTEPLSEDD FDMFYETWEK
1810 1820 1830 1840 1850
FDPEATQFIE YSALSDFADA LSEPLRIAKP NQISLINMDL PMVSGDRIHC
1860 1870 1880 1890 1900
MDILFAFTKR VLGESGEMDA LKIQMEEKFM AANPSKISYE PITTTLRRKH
1910 1920 1930 1940 1950
EEVSATVIQR AFRRHLLQRS MKHASFLFRQ QAGSGLSEED APEREGLIAY
1960 1970 1980 1990 2000
MMNENFSRPP GPPSSSSISS TSFPPSYDSV TRATSDNLQV RGSDDSHSED
2010
LADFPPSPDR DRESIV
Length:2,016
Mass (Da):227,105
Last modified:March 28, 2018 - v1
Checksum:i6C87C74CBFE61139
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K5Q6Q3A0A2K5Q6Q3_CEBCA
Sodium channel protein
SCN5A
2,015Annotation score:
A0A2K5Q719A0A2K5Q719_CEBCA
Sodium channel protein
SCN5A
2,016Annotation score:
A0A2K5Q6U5A0A2K5Q6U5_CEBCA
Sodium channel protein
SCN5A
1,998Annotation score:
A0A2K5Q6Z8A0A2K5Q6Z8_CEBCA
Sodium channel protein
SCN5A
1,962Annotation score:

Sequence databases

RefSeqiXP_017363867.1, XM_017508378.1

Genome annotation databases

EnsembliENSCCAT00000029007; ENSCCAP00000011599; ENSCCAG00000023536
GeneIDi108289099

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_017363867.1, XM_017508378.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCCAT00000029007; ENSCCAP00000011599; ENSCCAG00000023536
GeneIDi108289099

Organism-specific databases

CTDi6331

Phylogenomic databases

GeneTreeiENSGT00830000128242

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR008053 Na_channel_a5su
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR024583 Na_trans_cytopl
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PF11933 Na_trans_cytopl, 1 hit
PRINTSiPR00170 NACHANNEL
PR01666 NACHANNEL5
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2K5Q6Y6_CEBCA
AccessioniPrimary (citable) accession number: A0A2K5Q6Y6
Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: July 18, 2018
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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