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Protein

Protein disulfide-isomerase A4

Gene

PDIA4

Organism
Cebus capucinus imitator
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase A4UniRule annotation (EC:5.3.4.1UniRule annotation)
Alternative name(s):
Endoplasmic reticulum resident protein 72UniRule annotation
Gene namesi
Name:PDIA4Imported
OrganismiCebus capucinus imitatorImported
Taxonomic identifieri1737458 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCebinaeCebus
Proteomesi
  • UP000233040 Componenti: Whole Genome Shotgun Assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23UniRule annotationAdd BLAST23
ChainiPRO_501421111624 – 645Protein disulfide-isomerase A4UniRule annotationAdd BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi206 ↔ 209Redox-activeUniRule annotation
Disulfide bondi555 ↔ 558Redox-activeUniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 156ThioredoxinInterPro annotationAdd BLAST137
Domaini158 – 301ThioredoxinInterPro annotationAdd BLAST144
Domaini505 – 636ThioredoxinInterPro annotationAdd BLAST132

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili31 – 59Sequence analysisAdd BLAST29

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Redox-active centerUniRule annotationSAAS annotation, RepeatSAAS annotation, SignalUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00860000133691

Family and domain databases

InterProiView protein in InterPro
IPR005788 Disulphide_isomerase
IPR005792 Prot_disulphide_isomerase
IPR017068 Protein_diS-isomerase_A4
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 3 hits
PIRSFiPIRSF036862 Disulphide_isom_A4, 1 hit
SUPFAMiSSF52833 SSF52833, 5 hits
TIGRFAMsiTIGR01130 ER_PDI_fam, 1 hit
TIGR01126 pdi_dom, 3 hits
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 3 hits
PS51352 THIOREDOXIN_2, 3 hits

Sequencei

Sequence statusi: Complete.

A0A2K5PS71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPRKVCLLL LLLALAQLLV VAGADGPDED SSNKENAIED EEEEEEEDDE
60 70 80 90 100
EEDDDLEVKE ENGVLVLNDA NFDNFVADKD TVLLEFYAPW CGHCKQFAPE
110 120 130 140 150
YEKIASTLKD NDPPIPVAKI DATSASMLAS RFDVSGYPTI KILKKGQAVD
160 170 180 190 200
YEGSRTQEEI VAKVREVSQP DWTPPPEVTL VLTKENFDEV VNDADIILVE
210 220 230 240 250
FYAPWCGHCK KLAPEYEKAA KELSKRSPPI PLAKVDATAE TDLAKRFDVS
260 270 280 290 300
GYPTLKIFRK GRPFDYNGPR EKYGIVDYMI EQSGPPSKEI LTLKQVQEFL
310 320 330 340 350
KDGDDVIIIG AFKGESDPAY QQYQDAANNL REDYKFHHTF STEIAKFLKV
360 370 380 390 400
SQGQLVVMQP EKFQSKYEPR SHVMDVQGST EDLAIKDFIL KHALPLVGHR
410 420 430 440 450
KASNDAKRYT RRPLVVVYYS VDFSFDYRAA TQFWRSKVLE VAKDFPEYTF
460 470 480 490 500
AIADEEDYAG EVKDLGLSES GEDVNAAILD ESGKKFAMEP EEFDSDTLRE
510 520 530 540 550
FVTAFKKGKL KPVIKSQPVP KNNKGPVKVV VGKTFDSIVM DPKKDVLIEF
560 570 580 590 600
YAPWCGHCKQ LEPVYNSLGK KYKGQKGLVI AKMDATANDV PSDRYKVEGF
610 620 630 640
PTIYFAPSGD KKNPVKFEGG DRDLEHLSKF IEEHATKLGR TKEEL
Length:645
Mass (Da):72,734
Last modified:March 28, 2018 - v1
Checksum:i90EA8FAAF15F4ED5
GO

Sequence databases

RefSeqiXP_017358396.1, XM_017502907.1

Genome annotation databases

EnsembliENSCCAT00000023826; ENSCCAP00000006460; ENSCCAG00000020952
GeneIDi108285622

Similar proteinsi

Entry informationi

Entry nameiA0A2K5PS71_CEBCA
AccessioniPrimary (citable) accession number: A0A2K5PS71
Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: July 18, 2018
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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