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Entry version 9 (16 Jan 2019)
Sequence version 1 (28 Mar 2018)
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Protein
Submitted name:

CDK5 regulatory subunit associated protein 2

Gene

CDK5RAP2

Organism
Cebus capucinus imitator
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CDK5 regulatory subunit associated protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDK5RAP2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCebus capucinus imitatorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1737458 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCebinaeCebus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000233040 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Whole Genome Shotgun Assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini60 – 130Cnn_1NInterPro annotationAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili60 – 80Sequence analysisAdd BLAST21
Coiled coili103 – 130Sequence analysisAdd BLAST28
Coiled coili142 – 162Sequence analysisAdd BLAST21
Coiled coili216 – 243Sequence analysisAdd BLAST28
Coiled coili265 – 312Sequence analysisAdd BLAST48
Coiled coili320 – 361Sequence analysisAdd BLAST42
Coiled coili366 – 386Sequence analysisAdd BLAST21
Coiled coili394 – 467Sequence analysisAdd BLAST74
Coiled coili577 – 621Sequence analysisAdd BLAST45
Coiled coili961 – 988Sequence analysisAdd BLAST28
Coiled coili1198 – 1232Sequence analysisAdd BLAST35
Coiled coili1294 – 1317Sequence analysisAdd BLAST24
Coiled coili1396 – 1430Sequence analysisAdd BLAST35
Coiled coili1478 – 1526Sequence analysisAdd BLAST49

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063845

Database of Orthologous Groups

More...
OrthoDBi
1046642at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012943 Cnn_1N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07989 Cnn_1N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2K5PMG2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMDLVLEEDV TLPGTLSGCS GLVPNVPDDL DGITPKAGLG NGVLPNVSEE
60 70 80 90 100
TVSPTRARNM KDFENQITEL KKENFNLKLR IYFLEERMQQ EFQGPTEHIY
110 120 130 140 150
KTNIELKVEV ESLKRELQER ERLLIKASKA VESLAEAGGS EIQRVKEDAR
160 170 180 190 200
KKVQQVEDLL TKRILVLQKD AKAAQAQLEK AFAGTETEKA LRLSLESKLS
210 220 230 240 250
EMKKMHEGDL EMALVLDEKD RLIEELKLSL KSKEALIQCL KEEKSQMASP
260 270 280 290 300
DENVSSGELR GLFAARREEK ERETEAAQME HQKERNSFEE RIQALEEDLR
310 320 330 340 350
EKEREISTEK KNSLKRDKAI QGLTMALKSK EKEVEGLNSE IEKLSAAFAK
360 370 380 390 400
AREALQKAQT QEFQGSEGYE AALSEKEALL AELRSQNLTK STENHRLRRS
410 420 430 440 450
IKKITQELSD LQQERERLEK DLEEAHREKS KGECTILDLR NEVEKLRNEV
460 470 480 490 500
NEREKAMENH YKNLLSESSK KLHSQEQAIK HLTESTNQKD LLLQKFNEKD
510 520 530 540 550
LEVIQQNCYL MAAEDLQLRS EALITGKCSS QQSPGSKTVF SKEKKQSSDY
560 570 580 590 600
EELIQVLKKE QDIYTHLVKS LQESDSINNL QAELNNIFAL RKRLEWDVLS
610 620 630 640 650
YQNLRKTLEE QIGEIRRREE ESFSFYSDQT SYLSICLEEN NRFQVEHFSQ
660 670 680 690 700
EELKKKVSDL IQLVKELYTD NQRLKKTIFD LSCMGFQGNG FPDRLESTEK
710 720 730 740 750
TELLASKEDE DTIKTGEDDG SNFLSDQHLQ QSNEVMKDLS QGGCKNGYLR
760 770 780 790 800
HMESKILDYD GANTPGCLEE GEFMNLLAPL FNEKATLLLE SRPDLLKVLQ
810 820 830 840 850
ELLLGQLCLT EQEVSGERLD GKTEKTPKQK GELRHFVQTS SFSKPHDELQ
860 870 880 890 900
LSCEAQLVKA GGVPKVELTD ASVQTVATEG DLLTFKHEAK REAWDEQSTN
910 920 930 940 950
TALSAEHRPE NLRRVPGWQA ALPSFPGGTN REAKKSRLPI LMKPSGSSGN
960 970 980 990 1000
MYHLPGTQEV VAQLQNQILE LQGELKELKT CNEQLHQKLI LAEAMEDRRP
1010 1020 1030 1040 1050
TPNKMLLNAQ SPVGAAYQDS PGEQKGIKTT SVWRDKEMDS DQQTSYEIDS
1060 1070 1080 1090 1100
DICPPDDLAI LPSCKENPED VLSPTSIAPC LSSKSQPSVK VSVMGTDQSE
1110 1120 1130 1140 1150
SIDTSNEAEY LKQKIHDLET ELEGYQNFIF QLQKHSQCSE AIITVLCGTE
1160 1170 1180 1190 1200
GAQDGLSKPK GGSDEEEMTF SSLHQVRYVK HMKILHPLAP EMMDGRTPEN
1210 1220 1230 1240 1250
LQQQLEEQEY ELQKEQNLNM ELLSEIHNLQ NKFRDLSPSR YDSLVQSQAR
1260 1270 1280 1290 1300
ELSLQRKQIK DGHSICVVSR QHMNSMIKAF EELLQASDVD CCVAEGFQEQ
1310 1320 1330 1340 1350
LNQCAELLEK LEKLLLNGES AGVEMNTHTQ NELMERIEED NLTYQYLLPE
1360 1370 1380 1390 1400
SPEPSASHAP SDYETSEKSF FSRDQKQDNE MEKTSVTVNN FSQDLLMEHI
1410 1420 1430 1440 1450
QEIRTLRKRL EESIKTNEKL RKQLERQGSE FDQGSTNIFA SGSELHSSLT
1460 1470 1480 1490 1500
SEIHFLRKQN QALNAMLIKG SRDKQKENDK LRESLSRKTA SLEHLQREYA
1510 1520 1530 1540 1550
SVKEENERLQ KEGSEKERHN QQLIQEACRS RQELSRVQEE VKLRQQLLSQ
1560 1570 1580 1590 1600
NDKLLQSLRV ELKAYEKLDA EHRRPREASG EGWKGQDPFM DLHSLLMEIQ
1610 1620 1630 1640 1650
ALRLQLERSI QTNSMLQSRL EEQLAKGAEK AQEGALTLAV QALSIPELSL
1660 1670 1680 1690 1700
QPDKHDGDKY PMESDNSFDL FDSTQAVTPK SVSETPLLSG NDTDSLSCNS
1710 1720 1730 1740 1750
GSSATSTPCV SRLVTGHRLW ADKSGCHVLG LIEDYEALLK QIGQGQRLLA
1760 1770 1780 1790 1800
EMDIQTQETP SAASQELGTK GPHLVPLSKF VSSVSTARLT LEEAYRQLTR
1810 1820 1830 1840 1850
LWRVSLPSDG QCPLHCKQIG EMKTEITKLH KKLFEQEKKL QNTVKLLQLS
1860 1870 1880 1890
KRQEKVIFDQ LVVTHKILRK ARGNLELRPR GAHPGTCSPS RPGS
Length:1,894
Mass (Da):215,296
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i835533E5AD120A85
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_017358776.1, XM_017503287.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCCAT00000022067; ENSCCAP00000004825; ENSCCAG00000019951

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
108285833

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_017358776.1, XM_017503287.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCCAT00000022067; ENSCCAP00000004825; ENSCCAG00000019951
GeneIDi108285833

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55755

Phylogenomic databases

GeneTreeiENSGT00530000063845
OrthoDBi1046642at2759

Family and domain databases

InterProiView protein in InterPro
IPR012943 Cnn_1N
PfamiView protein in Pfam
PF07989 Cnn_1N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K5PMG2_CEBCA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K5PMG2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: January 16, 2019
This is version 9 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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