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UniProtKB - A0A2K5MWP8 (A0A2K5MWP8_CERAT)

Entry version 18 (02 Jun 2021)
Sequence version 1 (28 Mar 2018)
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Protein

Threonyl-tRNA synthetase

Gene

TARS1

Organism
Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminoacyl-tRNA synthetaseARBA annotation, Ligase
Biological processProtein biosynthesisARBA annotation
LigandATP-bindingARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Threonyl-tRNA synthetaseARBA annotation (EC:6.1.1.3ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TARS1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9531 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Cercocebus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000233060 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini79 – 160TGSInterPro annotationAdd BLAST82
Domaini364 – 636AA_TRNA_LIGASE_IIInterPro annotationAdd BLAST273

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 46DisorderedSequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi17 – 41Basic and acidic residuesSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.ARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154969

Family and domain databases

Conserved Domains Database

More...CDDi		cd00771, ThrRS_core, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.10.20.30, 2 hits
3.40.50.800, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00184, Thr_tRNA_synth, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002314, aa-tRNA-synt_IIb
IPR006195, aa-tRNA-synth_II
IPR004154, Anticodon-bd
IPR036621, Anticodon-bd_dom_sf
IPR012675, Beta-grasp_dom_sf
IPR004095, TGS
IPR012676, TGS-like
IPR002320, Thr-tRNA-ligase_IIa
IPR018163, Thr/Ala-tRNA-synth_IIc_edit
IPR033728, ThrRS_core
IPR012947, tRNA_SAD

The PANTHER Classification System

More...PANTHERi		PTHR11451, PTHR11451, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03129, HGTP_anticodon, 1 hit
PF02824, TGS, 1 hit
PF00587, tRNA-synt_2b, 1 hit
PF07973, tRNA_SAD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01047, TRNASYNTHTHR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00863, tRNA_SAD, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55186, SSF55186, 1 hit
SSF81271, SSF81271, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00418, thrS, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50862, AA_TRNA_LIGASE_II, 1 hit
PS51880, TGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A2K5MWP8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFEEKASSPS GKMGGEEKPI DAGEEKRKEG GKKKSKEGSG DGGRAELNPW 
        60         70         80         90        100
PEYIYTRLEM YNILKAEHDS LLAEKAEKDS KPIKVTLPDG KQVDAESWKT 
       110        120        130        140        150
TPYQIACGIR YKLLCSYICM DIYFLLSQGL ADNTVIAKVN NVVWDLDRPL 
       160        170        180        190        200
EEDCTLELLK FEDEEAQAVY WHSSAHIMGE AMERVYGGCL CYGPPIENGF 
       210        220        230        240        250
YYDMYLEEGG VSSNDFSSLE SLCKKIIKEK QAFERLEVKK ETLLAMFKYN 
       260        270        280        290        300
KFKCRILNEK VNTPTTTVYR CGPLIDLCRG PHVRHTGKIK ALKIHKNSST 
       310        320        330        340        350
YWEGKADMET LQRIYGISFP DPKMLKEWEK FQEEAKNRDH RKIGRDQELY 
       360        370        380        390        400
FFHELSPGSC FFLPKGAYIY NALIEFIRSE YRKRGFQEVV TPNIFNSRLW 
       410        420        430        440        450
MTSGHWQHYS ENMFSFEVEK ELFALKPMNC PGHCLMFDHR PRSWRELPLR 
       460        470        480        490        500
LADFGVLHRN ELSGALTGLT RVRRFQQDDA HIFCAMEQIE DEIKGCLDFL 
       510        520        530        540        550
RTVYSVFGFS FKLNLSTRPE KFLGDIEVWD QAEKQLENSL NEFGEKWELN 
       560        570        580        590        600
SGDGAFYVSL AFYNNPIDIQ IKDAIGRYHQ CATIQLDFQL PIRFNLTYVS 
       610        620        630        640        650
HDGDDKKRPV IVHRAILGSV ERMIAILTEN YGGKWPFWLS PRQVMVVPVG 
       660        670        680        690        700
PTCDEYAQKV RQQFHDAKFM ADIDLDPGCT LNKKIRNAQL AQYNFILVVG 
       710        720        730        740 
EKEKISGTVN IRTRDNKVHG ERTISETMER LQQLKEYRSK QAEEEF
Length:746
Mass (Da):86,408
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1DEF18086E4D9CAC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K5MX60A0A2K5MX60_CERAT
Threonyl-tRNA synthetase
TARS1
723Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K5MWR0A0A2K5MWR0_CERAT
Threonyl-tRNA synthetase 1
TARS1
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K5MX70A0A2K5MX70_CERAT
Threonyl-tRNA synthetase 1
TARS1
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSCATT00000053928; ENSCATP00000029668; ENSCATG00000038037

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSCATT00000053928; ENSCATP00000029668; ENSCATG00000038037

Phylogenomic databases

GeneTreeiENSGT00940000154969

Family and domain databases

CDDicd00771, ThrRS_core, 1 hit
Gene3Di3.10.20.30, 2 hits
3.40.50.800, 1 hit
HAMAPiMF_00184, Thr_tRNA_synth, 1 hit
InterProiView protein in InterPro
IPR002314, aa-tRNA-synt_IIb
IPR006195, aa-tRNA-synth_II
IPR004154, Anticodon-bd
IPR036621, Anticodon-bd_dom_sf
IPR012675, Beta-grasp_dom_sf
IPR004095, TGS
IPR012676, TGS-like
IPR002320, Thr-tRNA-ligase_IIa
IPR018163, Thr/Ala-tRNA-synth_IIc_edit
IPR033728, ThrRS_core
IPR012947, tRNA_SAD
PANTHERiPTHR11451, PTHR11451, 1 hit
PfamiView protein in Pfam
PF03129, HGTP_anticodon, 1 hit
PF02824, TGS, 1 hit
PF00587, tRNA-synt_2b, 1 hit
PF07973, tRNA_SAD, 1 hit
PRINTSiPR01047, TRNASYNTHTHR
SMARTiView protein in SMART
SM00863, tRNA_SAD, 1 hit
SUPFAMiSSF55186, SSF55186, 1 hit
SSF81271, SSF81271, 1 hit
TIGRFAMsiTIGR00418, thrS, 1 hit
PROSITEiView protein in PROSITE
PS50862, AA_TRNA_LIGASE_II, 1 hit
PS51880, TGS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K5MWP8_CERAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K5MWP8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: June 2, 2021
This is version 18 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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