UniProtKB - A0A2K5MWP8 (A0A2K5MWP8_CERAT)
Protein
Threonyl-tRNA synthetase
Gene
TARS1
Organism
Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
Status
Functioni
Catalytic activityi
- EC:6.1.1.3ARBA annotation
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- identical protein binding Source: Ensembl
- threonine-tRNA ligase activity Source: UniProtKB-EC
- zinc ion binding Source: Ensembl
GO - Biological processi
- threonyl-tRNA aminoacylation Source: Ensembl
Keywordsi
Molecular function | Aminoacyl-tRNA synthetaseARBA annotation, Ligase |
Biological process | Protein biosynthesisARBA annotation |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:TARS1Imported |
Organismi | Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)Imported |
Taxonomic identifieri | 9531 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Cercocebus |
Proteomesi |
|
Subcellular locationi
Cytoskeleton
- actin cytoskeleton Source: Ensembl
Cytosol
- cytosol Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 79 – 160 | TGSInterPro annotationAdd BLAST | 82 | |
Domaini | 364 – 636 | AA_TRNA_LIGASE_IIInterPro annotationAdd BLAST | 273 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 46 | DisorderedSequence analysisAdd BLAST | 46 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 17 – 41 | PolyampholyteSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the class-II aminoacyl-tRNA synthetase family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000154969 |
Family and domain databases
CDDi | cd00771, ThrRS_core, 1 hit |
Gene3Di | 3.10.20.30, 2 hits 3.40.50.800, 1 hit |
HAMAPi | MF_00184, Thr_tRNA_synth, 1 hit |
InterProi | View protein in InterPro IPR002314, aa-tRNA-synt_IIb IPR006195, aa-tRNA-synth_II IPR004154, Anticodon-bd IPR036621, Anticodon-bd_dom_sf IPR012675, Beta-grasp_dom_sf IPR004095, TGS IPR012676, TGS-like IPR002320, Thr-tRNA-ligase_IIa IPR018163, Thr/Ala-tRNA-synth_IIc_edit IPR033728, ThrRS_core IPR012947, tRNA_SAD |
PANTHERi | PTHR11451, PTHR11451, 1 hit |
Pfami | View protein in Pfam PF03129, HGTP_anticodon, 1 hit PF02824, TGS, 1 hit PF00587, tRNA-synt_2b, 1 hit PF07973, tRNA_SAD, 1 hit |
PRINTSi | PR01047, TRNASYNTHTHR |
SMARTi | View protein in SMART SM00863, tRNA_SAD, 1 hit |
SUPFAMi | SSF55186, SSF55186, 1 hit SSF81271, SSF81271, 1 hit |
TIGRFAMsi | TIGR00418, thrS, 1 hit |
PROSITEi | View protein in PROSITE PS50862, AA_TRNA_LIGASE_II, 1 hit PS51880, TGS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
A0A2K5MWP8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFEEKASSPS GKMGGEEKPI DAGEEKRKEG GKKKSKEGSG DGGRAELNPW
60 70 80 90 100
PEYIYTRLEM YNILKAEHDS LLAEKAEKDS KPIKVTLPDG KQVDAESWKT
110 120 130 140 150
TPYQIACGIR YKLLCSYICM DIYFLLSQGL ADNTVIAKVN NVVWDLDRPL
160 170 180 190 200
EEDCTLELLK FEDEEAQAVY WHSSAHIMGE AMERVYGGCL CYGPPIENGF
210 220 230 240 250
YYDMYLEEGG VSSNDFSSLE SLCKKIIKEK QAFERLEVKK ETLLAMFKYN
260 270 280 290 300
KFKCRILNEK VNTPTTTVYR CGPLIDLCRG PHVRHTGKIK ALKIHKNSST
310 320 330 340 350
YWEGKADMET LQRIYGISFP DPKMLKEWEK FQEEAKNRDH RKIGRDQELY
360 370 380 390 400
FFHELSPGSC FFLPKGAYIY NALIEFIRSE YRKRGFQEVV TPNIFNSRLW
410 420 430 440 450
MTSGHWQHYS ENMFSFEVEK ELFALKPMNC PGHCLMFDHR PRSWRELPLR
460 470 480 490 500
LADFGVLHRN ELSGALTGLT RVRRFQQDDA HIFCAMEQIE DEIKGCLDFL
510 520 530 540 550
RTVYSVFGFS FKLNLSTRPE KFLGDIEVWD QAEKQLENSL NEFGEKWELN
560 570 580 590 600
SGDGAFYVSL AFYNNPIDIQ IKDAIGRYHQ CATIQLDFQL PIRFNLTYVS
610 620 630 640 650
HDGDDKKRPV IVHRAILGSV ERMIAILTEN YGGKWPFWLS PRQVMVVPVG
660 670 680 690 700
PTCDEYAQKV RQQFHDAKFM ADIDLDPGCT LNKKIRNAQL AQYNFILVVG
710 720 730 740
EKEKISGTVN IRTRDNKVHG ERTISETMER LQQLKEYRSK QAEEEF
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2K5MX60 | A0A2K5MX60_CERAT | Threonyl-tRNA synthetase | TARS1 | 723 | Annotation score: | ||
A0A2K5MWR0 | A0A2K5MWR0_CERAT | Uncharacterized protein | TARS1 | 56 | Annotation score: | ||
A0A2K5MX70 | A0A2K5MX70_CERAT | Uncharacterized protein | TARS1 | 66 | Annotation score: |
Genome annotation databases
Ensembli | ENSCATT00000053928; ENSCATP00000029668; ENSCATG00000038037 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSCATT00000053928; ENSCATP00000029668; ENSCATG00000038037 |
Phylogenomic databases
GeneTreei | ENSGT00940000154969 |
Family and domain databases
CDDi | cd00771, ThrRS_core, 1 hit |
Gene3Di | 3.10.20.30, 2 hits 3.40.50.800, 1 hit |
HAMAPi | MF_00184, Thr_tRNA_synth, 1 hit |
InterProi | View protein in InterPro IPR002314, aa-tRNA-synt_IIb IPR006195, aa-tRNA-synth_II IPR004154, Anticodon-bd IPR036621, Anticodon-bd_dom_sf IPR012675, Beta-grasp_dom_sf IPR004095, TGS IPR012676, TGS-like IPR002320, Thr-tRNA-ligase_IIa IPR018163, Thr/Ala-tRNA-synth_IIc_edit IPR033728, ThrRS_core IPR012947, tRNA_SAD |
PANTHERi | PTHR11451, PTHR11451, 1 hit |
Pfami | View protein in Pfam PF03129, HGTP_anticodon, 1 hit PF02824, TGS, 1 hit PF00587, tRNA-synt_2b, 1 hit PF07973, tRNA_SAD, 1 hit |
PRINTSi | PR01047, TRNASYNTHTHR |
SMARTi | View protein in SMART SM00863, tRNA_SAD, 1 hit |
SUPFAMi | SSF55186, SSF55186, 1 hit SSF81271, SSF81271, 1 hit |
TIGRFAMsi | TIGR00418, thrS, 1 hit |
PROSITEi | View protein in PROSITE PS50862, AA_TRNA_LIGASE_II, 1 hit PS51880, TGS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A2K5MWP8_CERAT | |
Accessioni | A0A2K5MWP8Primary (citable) accession number: A0A2K5MWP8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 28, 2018 |
Last sequence update: | March 28, 2018 | |
Last modified: | December 2, 2020 | |
This is version 15 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |