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Entry version 14 (07 Apr 2021)
Sequence version 1 (28 Mar 2018)
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Protein
Submitted name:

Uncharacterized protein

Gene

TNRC6A

Organism
Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNRC6AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9531 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeCercocebus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000233060 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 15Sequence analysisAdd BLAST15
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501446985216 – 1974Sequence analysisAdd BLAST1959

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1088 – 1214Ago_hookInterPro annotationAdd BLAST127
Domaini1293 – 1493M_domainInterPro annotationAdd BLAST201
Domaini1517 – 1790TNRC6-PABC_bdgInterPro annotationAdd BLAST274

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni49 – 147DisorderedSequence analysisAdd BLAST99
Regioni186 – 307DisorderedSequence analysisAdd BLAST122
Regioni448 – 467DisorderedSequence analysisAdd BLAST20
Regioni507 – 529DisorderedSequence analysisAdd BLAST23
Regioni571 – 712DisorderedSequence analysisAdd BLAST142
Regioni731 – 1148DisorderedSequence analysisAdd BLAST418
Regioni1176 – 1207DisorderedSequence analysisAdd BLAST32
Regioni1262 – 1285DisorderedSequence analysisAdd BLAST24
Regioni1436 – 1468DisorderedSequence analysisAdd BLAST33
Regioni1589 – 1647DisorderedSequence analysisAdd BLAST59
Regioni1736 – 1758DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi64 – 127PolarSequence analysisAdd BLAST64
Compositional biasi186 – 243PolarSequence analysisAdd BLAST58
Compositional biasi268 – 307PolarSequence analysisAdd BLAST40
Compositional biasi571 – 689PolarSequence analysisAdd BLAST119
Compositional biasi690 – 712PolyampholyteSequence analysisAdd BLAST23
Compositional biasi731 – 750PolarSequence analysisAdd BLAST20
Compositional biasi762 – 795PolarSequence analysisAdd BLAST34
Compositional biasi814 – 963PolarSequence analysisAdd BLAST150
Compositional biasi995 – 1017PolyampholyteSequence analysisAdd BLAST23
Compositional biasi1024 – 1070PolarSequence analysisAdd BLAST47
Compositional biasi1107 – 1132PolarSequence analysisAdd BLAST26
Compositional biasi1738 – 1752Pro-richSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GW182 family.ARBA annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158180

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12711, RRM_TNRC6A, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019486, Argonaute_hook_dom
IPR026805, GW182_M_dom
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR032226, TNRC6_PABC-bd
IPR033501, TNRC6A
IPR034924, TNRC6A_RRM

The PANTHER Classification System

More...
PANTHERi
PTHR13020:SF28, PTHR13020:SF28, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10427, Ago_hook, 1 hit
PF12938, M_domain, 1 hit
PF16608, TNRC6-PABC_bdg, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928, SSF54928, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A2K5L0C1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFLFLFSFLE RGSYCCKTLE SEVAVSQDHT IALQPGQQVQ NPVFKKKTKN
60 70 80 90 100
KKKLLKAGCS VPEQIKPSVS QPQPANSNNG TSTATSTNNN AKRATANNQQ
110 120 130 140 150
PQQQPQQPQQ QQQQPQQQQQ QQPQQPQQQP QPQQPQQQPQ ALPRYPREVP
160 170 180 190 200
PRFRHQEHKQ LLKRGQHFPV IAANLGSAVK VLNSQSESSA LTNQQPQNNG
210 220 230 240 250
EVQNSKNQSD INHSTSGSHY ENSQRGLVSS TSDSSTNCKN AVVSDLSEKE
260 270 280 290 300
AWPSVPGSDP ELASECMDAD SASSSESERN ITIMASGNTG GEKDGLRNST
310 320 330 340 350
GLGSQNKFVV GSSSNNVGHG SSTGPWGFSH GAIISTCQVS VDAPESKSES
360 370 380 390 400
SNNRMNAWGT VSSSSNGGLN PSTLNSASNH GAWPVLENNG LALKGPVGSG
410 420 430 440 450
SSGINIQCST IGQMPNNQSI NSKVSGGSTH GTWGSLQETC ESEVSGTQKV
460 470 480 490 500
SFSGQPQNIT TEMTGPNNTT NFMTSSLPNS GSVQNNELPS SNTGAWRVST
510 520 530 540 550
MNHPQMQAPS GMNGTSLSHL SNGESKSGGS YGTTWGAYGS NYSGDKCSGP
560 570 580 590 600
NGQANGDTVN ATLMQPGVNG PMGTNFQVNT NKGGGVWESG AANSQSASWG
610 620 630 640 650
SGNGANSGGS RRGWGTPAQN TGTNLPSGEW NKLPSNQHSN DSANGNGKKF
660 670 680 690 700
TNGWKSTEEE DQGSATSQTN EQSSVWAKTG GTVESDGSTE STGRLEEKGT
710 720 730 740 750
GESQSRDRRK IDQHTLLQSI VNRTDLDPRV LSNSGWGQTP IKQNTAWDTE
760 770 780 790 800
TSPRGERKTD NGTEAWGSSA TQTFNSGACI DKTSPNSNDT SSVSGWGDPK
810 820 830 840 850
PALRWGDSKG SNCQGGWEDD SAATGMVKSN QWGNCKEEKA TWNDSQKNKQ
860 870 880 890 900
GWGDGQKSSQ GWSVSASDNW GETSRSNHWG EANKKSSSGG SDSDRSVSGW
910 920 930 940 950
NELGKTSSFT WGNNINPNNS SGWDESSKPT PSQGWGDPPK SNQSLGWGDS
960 970 980 990 1000
SKPVSSPDWN KQQDIVGSWG IPPATGKPPG TGWLGGPIPA PTKEEEPTGW
1010 1020 1030 1040 1050
EEPSPESIRR KMEIDDGTSA WGDPSKYNYK NVNMWNKNVP NGNSRSDQQA
1060 1070 1080 1090 1100
QVHQLLTPAS AISNKEASSG SGWGEPWGEP STPATTVDNG TSAWGKPIDS
1110 1120 1130 1140 1150
GPSWGEPIAA ASSTSTWGSS SVGPQALNKS GPKSMQDGWC GDDMPLPGNR
1160 1170 1180 1190 1200
PTGWEEEEDV EIGMWNSNSS QELNSSLNWP PYTKKMSSKG LSGKKRRRER
1210 1220 1230 1240 1250
GMMKGGNKQE EAWINPFVKQ FSNISFSRDS PEENVQSNKM DLSGGMLQDK
1260 1270 1280 1290 1300
RMEIDKHSLN IGDYNRTVGK GPGSRPQISK ESSMERNPYF DKDGIVADES
1310 1320 1330 1340 1350
QNMQFMSSQS MKLPPSNSAL PNQALGSIAG LGMQNLNSVR QVSPDYNVAM
1360 1370 1380 1390 1400
RCFMFGVGNT APPAQPLSSS QPNLRAQVPP PLLSPQVPVS LLKYAPNNGG
1410 1420 1430 1440 1450
LNPLFGPQQV AMLNQLSQLN QLSQISQLQR LLAQQQRAQS QRSVPSGNRP
1460 1470 1480 1490 1500
QQDQQGRPLS VQQQMMQQSR QLDPNLLVKQ QTPPSQQQPL HQPAMKSFLD
1510 1520 1530 1540 1550
NVMPHTTPEL QKGPSPINAF SNFPIGLNSN LNVNMDMNSI KEPQSRLRKW
1560 1570 1580 1590 1600
TTVDSISVNT SLDQNSSKHG AISSGFRLEE SPFVPYDFMN SSTSPASPPG
1610 1620 1630 1640 1650
SIGDGWPRAK SPNGSSSVNW PPEFRPGEPW KGYPNIDPET DPYVTPGSVI
1660 1670 1680 1690 1700
NNLSINTVRE VDHLRDRNSG SSSSLNTTLP STSAWSSIRA SNYNVPLSST
1710 1720 1730 1740 1750
AQSTSARNSD SKLTWSPGSV TNTSLAHELW KVPLPPKNIT APSRPPPGLT
1760 1770 1780 1790 1800
GQKPPLSTWD NSPLRVGGGW GNSDARYTPG SSWGESSSGR ITNWLVLKNL
1810 1820 1830 1840 1850
TPQIDGSTLR TLCMQHGPLI TFHLNLPHGN ALVRYSSKEE VVKAQKSLHM
1860 1870 1880 1890 1900
CVLGNTTILA EFASEEEISR FFAQSQSLTP SPGWQSLGSS QSRLGSLDCS
1910 1920 1930 1940 1950
HSFSSRTDLN HWNGAGLSGT NCGDLHGTSL WGTPHYSTSL WGPPSSSDPR
1960 1970
GISSPSPINA FLSVDHLGGG GESM
Length:1,974
Mass (Da):211,561
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i820ED7EA57BEBB76
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K5L076A0A2K5L076_CERAT
Uncharacterized protein
TNRC6A
1,862Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K5L032A0A2K5L032_CERAT
Uncharacterized protein
TNRC6A
1,929Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K5L057A0A2K5L057_CERAT
Uncharacterized protein
TNRC6A
1,904Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K5L049A0A2K5L049_CERAT
Uncharacterized protein
TNRC6A
1,870Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCATT00000023009; ENSCATP00000006373; ENSCATG00000019284

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSCATT00000023009; ENSCATP00000006373; ENSCATG00000019284

Phylogenomic databases

GeneTreeiENSGT00940000158180

Family and domain databases

CDDicd12711, RRM_TNRC6A, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR019486, Argonaute_hook_dom
IPR026805, GW182_M_dom
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR032226, TNRC6_PABC-bd
IPR033501, TNRC6A
IPR034924, TNRC6A_RRM
PANTHERiPTHR13020:SF28, PTHR13020:SF28, 1 hit
PfamiView protein in Pfam
PF10427, Ago_hook, 1 hit
PF12938, M_domain, 1 hit
PF16608, TNRC6-PABC_bdg, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K5L0C1_CERAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K5L0C1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: April 7, 2021
This is version 14 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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