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UniProtKB - A0A2K5K3N7 (A0A2K5K3N7_COLAP)

Entry version 13 (10 Feb 2021)
Sequence version 1 (28 Mar 2018)
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Protein
Submitted name:

Uncharacterized protein

Gene

TNRC6A

Organism
Colobus angolensis palliatus (Peters' Angolan colobus)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRNA-mediated gene silencingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNRC6AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiColobus angolensis palliatus (Peters' Angolan colobus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri336983 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Colobinae › Colobus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000233080 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei27 – 49HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1063 – 1191Ago_hookInterPro annotationAdd BLAST129
Domaini1493 – 1756TNRC6-PABC_bdgInterPro annotationAdd BLAST264

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni55 – 124DisorderedSequence analysisAdd BLAST70
Regioni163 – 284DisorderedSequence analysisAdd BLAST122
Regioni425 – 444DisorderedSequence analysisAdd BLAST20
Regioni484 – 506DisorderedSequence analysisAdd BLAST23
Regioni548 – 689DisorderedSequence analysisAdd BLAST142
Regioni708 – 1125DisorderedSequence analysisAdd BLAST418
Regioni1153 – 1184DisorderedSequence analysisAdd BLAST32
Regioni1240 – 1262DisorderedSequence analysisAdd BLAST23
Regioni1412 – 1444DisorderedSequence analysisAdd BLAST33
Regioni1565 – 1623DisorderedSequence analysisAdd BLAST59
Regioni1712 – 1734DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi55 – 103PolarSequence analysisAdd BLAST49
Compositional biasi104 – 123Pro-richSequence analysisAdd BLAST20
Compositional biasi163 – 220PolarSequence analysisAdd BLAST58
Compositional biasi245 – 284PolarSequence analysisAdd BLAST40
Compositional biasi548 – 666PolarSequence analysisAdd BLAST119
Compositional biasi667 – 689PolyampholyteSequence analysisAdd BLAST23
Compositional biasi708 – 727PolarSequence analysisAdd BLAST20
Compositional biasi739 – 772PolarSequence analysisAdd BLAST34
Compositional biasi791 – 808PolarSequence analysisAdd BLAST18
Compositional biasi822 – 940PolarSequence analysisAdd BLAST119
Compositional biasi972 – 994PolyampholyteSequence analysisAdd BLAST23
Compositional biasi1001 – 1047PolarSequence analysisAdd BLAST47
Compositional biasi1084 – 1109PolarSequence analysisAdd BLAST26
Compositional biasi1714 – 1728Pro-richSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GW182 family.ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158180

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019486, Argonaute_hook_dom
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR032226, TNRC6_PABC-bd
IPR033501, TNRC6A

The PANTHER Classification System

More...PANTHERi		PTHR13020:SF28, PTHR13020:SF28, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10427, Ago_hook, 1 hit
PF16608, TNRC6-PABC_bdg, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928, SSF54928, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A2K5K3N7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VAVSQDCTTS ETLVSKNKYT LVKKKKMAYF GGTLYWLMFS TPFLLLGLVP 
        60         70         80         90        100
EQIKPSVSQP QPANSNNGTS TATSTNNNAK RATANNQQPQ QQPQQQPQQP 
       110        120        130        140        150
QQQPQQPQQQ PQPQQPQALP RYPREVPPRF RHQEHKQLLK RGQHFPVIAA 
       160        170        180        190        200
NLGSAVKVLN SQSESSALTN QQPQNNGEVQ NSKNQSDINH STSGSHYENS 
       210        220        230        240        250
QRGLVSSTSD SSTNCKNAVV SDLSEKEAWP SVPGSDPELA SECMDADSAS 
       260        270        280        290        300
SSESERNITI MASGNTGGEK DGLRNSTGLG SQNKFVVGSS SNNVGHGSST 
       310        320        330        340        350
GPWGFSHGAI ISTCQVSVDA PESKSESSNN RMNAWGTVSS SSNGGLNPST 
       360        370        380        390        400
LNSASNHGAW PVLENNGLAL KGPVGSGSSG INIQCSTIGQ MPNNQSINSK 
       410        420        430        440        450
VSGGSTHGTW GSLQETCESE VSGTQKVSFS GQPQNITTEM TGPNNTTNFM 
       460        470        480        490        500
TSSLPNSGSV QNNELPSSNT GAWRVSTMNH PQMQAPSGMN GTSLSHLSNG 
       510        520        530        540        550
ESKSGGSYGT TWGAYGSNYS GDKCSGPNGQ ANGDTVNATL MQPGVNGPMG 
       560        570        580        590        600
TNFQVNTNKG GGVWESGAAN SQSASWGSGN GANSGGSRRG WGTPAQNTGT 
       610        620        630        640        650
NLPSGEWNKL PSNQHSNDSA NGNGKKFTNG WKSTEEEDQG SATSQTNEQS 
       660        670        680        690        700
SVWAKTGGTV ESDGSTESTG RLEEKGTGES QSRDRRKIDQ HTLLQSIVNR 
       710        720        730        740        750
TDLDPRVLSN SGWGQTPIKQ NTAWDTETSP RGERKTDNGT EAWGSSATQT 
       760        770        780        790        800
FNSGACIDKT SPNSNDTSSV SGWGDPKPAL RWGDSKGSNC QGGWEDDSAA 
       810        820        830        840        850
TGMVKSNQWG NCKEEKAAWN DSQKNKQGWG DGQKSSQGWS VSASDNWGET 
       860        870        880        890        900
SRSNHWGEAN KKSSSGGSDS DRSVSGWNEL GKTSSFTWGN NINPNNSSGW 
       910        920        930        940        950
DESSKPTPSQ GWGDPPKSNQ SLGWGDSSKP VSSPDWNKQQ DIVGSWGIPP 
       960        970        980        990       1000
ATGKPPGTGW LGGPIPAPTK EEEPTGWEEP SPESIRRKME IDDGTSAWGD 
      1010       1020       1030       1040       1050
PSKYNYKNVN MWNKNVPNGN SRSDQQAQVH QLLTPASAIS NKEASSGSGW 
      1060       1070       1080       1090       1100
GEPWGEPSTP ATTVDNGTSA WGKPIDSGPS WGEPIAAASS TSTWGSSSVG 
      1110       1120       1130       1140       1150
PQALSKSGPK SMQDGWCGDD MPLPGNRPTG WEEEEDVEIG MWNSNSSQEL 
      1160       1170       1180       1190       1200
NSSLNWPPYT KKMSSKGLSG KKRRRERGMM KGGNKQEEAW INPFVKQFSN 
      1210       1220       1230       1240       1250
ISFSRDSPEE NVQSNKMDLS GGMLQDKRME IDKHSLNIGD YNRTVGKGPG 
      1260       1270       1280       1290       1300
SRPQISKESS MERNPYFDKD GIVADESQNM QFMSSQSMKL PPSNSALPNQ 
      1310       1320       1330       1340       1350
ALGSIAGLGM QNLNSVRQVS PDYNVAMRCF MFGVGNTAAQ PRGISSQPNL 
      1360       1370       1380       1390       1400
RAQVPPPLLS PQVPVSLLKY APNNGGLNPL FGPQQVAMLN QLSQLNQLSQ 
      1410       1420       1430       1440       1450
ISQLQRLLAQ QQRAQSQRSV PSGNRPQQDQ QGRPLSVQQQ MMQQSRQLDP 
      1460       1470       1480       1490       1500
NLLVKQQTPP SQQQPLHQPA MKSFLDNVMP HTTPELQKGP SPINAFSNFP 
      1510       1520       1530       1540       1550
IGLNSNLNVN MDLNSIKEPQ SRLRKWTTVD SISVNTSLDQ NSSKHGAISS 
      1560       1570       1580       1590       1600
GFRLEESPFV PYDFMNSSTS PASPPGSIGD GWPRAKSPNG SSSVNWPPEF 
      1610       1620       1630       1640       1650
RPGEPWKGYP NIDPETDPYV TPGSVINNLS INTVREVDHL RDRNSGSSSS 
      1660       1670       1680       1690       1700
LNTTLPSTSA WSSIRASNYN VPLSSTAQST SARNSDSKLT WSPGSVTNTS 
      1710       1720       1730       1740       1750
LAHELWKVPL PPKNITAPSR PPPGLTGQKP PLSTWDNSPL RVGGGWGNSD 
      1760       1770       1780       1790       1800
ARYTPGKMQY LRWFSVIDGS TLRTLCMQHG PLITFHLNLP HGNALVRYSS 
      1810       1820       1830       1840       1850
KEEVVKAQKS LHMCVLGNTT ILAEFASEEE ISRFFAQSQS LTPSPGWQSL 
      1860       1870       1880       1890       1900
GSSQSRLGSL DCSHSFSSRT DLNHWNGAGL SGTNCGDLHG TSLWGTPHYS 
      1910       1920       1930 
TSLWGPPSSS DPRGISSPSP INAFLSVDHL GGGGESM
Length:1,937
Mass (Da):207,465
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8EF2C223A69C9B52
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K5K3U9A0A2K5K3U9_COLAP
Uncharacterized protein
TNRC6A
1,958Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K5K3P5A0A2K5K3P5_COLAP
Uncharacterized protein
TNRC6A
1,909Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSCANT00000058971; ENSCANP00000035729; ENSCANG00000041549

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSCANT00000058971; ENSCANP00000035729; ENSCANG00000041549

Phylogenomic databases

GeneTreeiENSGT00940000158180

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR019486, Argonaute_hook_dom
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR032226, TNRC6_PABC-bd
IPR033501, TNRC6A
PANTHERiPTHR13020:SF28, PTHR13020:SF28, 1 hit
PfamiView protein in Pfam
PF10427, Ago_hook, 1 hit
PF16608, TNRC6-PABC_bdg, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K5K3N7_COLAP
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K5K3N7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: February 10, 2021
This is version 13 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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