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Entry version 13 (10 Feb 2021)
Sequence version 1 (28 Mar 2018)
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Protein
Submitted name:

Uncharacterized protein

Gene

TNRC6A

Organism
Colobus angolensis palliatus (Peters' Angolan colobus)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRNA-mediated gene silencingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNRC6AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiColobus angolensis palliatus (Peters' Angolan colobus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri336983 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeColobinaeColobus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000233080 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei27 – 49HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1063 – 1191Ago_hookInterPro annotationAdd BLAST129
Domaini1493 – 1756TNRC6-PABC_bdgInterPro annotationAdd BLAST264

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni55 – 124DisorderedSequence analysisAdd BLAST70
Regioni163 – 284DisorderedSequence analysisAdd BLAST122
Regioni425 – 444DisorderedSequence analysisAdd BLAST20
Regioni484 – 506DisorderedSequence analysisAdd BLAST23
Regioni548 – 689DisorderedSequence analysisAdd BLAST142
Regioni708 – 1125DisorderedSequence analysisAdd BLAST418
Regioni1153 – 1184DisorderedSequence analysisAdd BLAST32
Regioni1240 – 1262DisorderedSequence analysisAdd BLAST23
Regioni1412 – 1444DisorderedSequence analysisAdd BLAST33
Regioni1565 – 1623DisorderedSequence analysisAdd BLAST59
Regioni1712 – 1734DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi55 – 103PolarSequence analysisAdd BLAST49
Compositional biasi104 – 123Pro-richSequence analysisAdd BLAST20
Compositional biasi163 – 220PolarSequence analysisAdd BLAST58
Compositional biasi245 – 284PolarSequence analysisAdd BLAST40
Compositional biasi548 – 666PolarSequence analysisAdd BLAST119
Compositional biasi667 – 689PolyampholyteSequence analysisAdd BLAST23
Compositional biasi708 – 727PolarSequence analysisAdd BLAST20
Compositional biasi739 – 772PolarSequence analysisAdd BLAST34
Compositional biasi791 – 808PolarSequence analysisAdd BLAST18
Compositional biasi822 – 940PolarSequence analysisAdd BLAST119
Compositional biasi972 – 994PolyampholyteSequence analysisAdd BLAST23
Compositional biasi1001 – 1047PolarSequence analysisAdd BLAST47
Compositional biasi1084 – 1109PolarSequence analysisAdd BLAST26
Compositional biasi1714 – 1728Pro-richSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GW182 family.ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158180

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019486, Argonaute_hook_dom
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR032226, TNRC6_PABC-bd
IPR033501, TNRC6A

The PANTHER Classification System

More...
PANTHERi
PTHR13020:SF28, PTHR13020:SF28, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10427, Ago_hook, 1 hit
PF16608, TNRC6-PABC_bdg, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928, SSF54928, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A2K5K3N7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VAVSQDCTTS ETLVSKNKYT LVKKKKMAYF GGTLYWLMFS TPFLLLGLVP
60 70 80 90 100
EQIKPSVSQP QPANSNNGTS TATSTNNNAK RATANNQQPQ QQPQQQPQQP
110 120 130 140 150
QQQPQQPQQQ PQPQQPQALP RYPREVPPRF RHQEHKQLLK RGQHFPVIAA
160 170 180 190 200
NLGSAVKVLN SQSESSALTN QQPQNNGEVQ NSKNQSDINH STSGSHYENS
210 220 230 240 250
QRGLVSSTSD SSTNCKNAVV SDLSEKEAWP SVPGSDPELA SECMDADSAS
260 270 280 290 300
SSESERNITI MASGNTGGEK DGLRNSTGLG SQNKFVVGSS SNNVGHGSST
310 320 330 340 350
GPWGFSHGAI ISTCQVSVDA PESKSESSNN RMNAWGTVSS SSNGGLNPST
360 370 380 390 400
LNSASNHGAW PVLENNGLAL KGPVGSGSSG INIQCSTIGQ MPNNQSINSK
410 420 430 440 450
VSGGSTHGTW GSLQETCESE VSGTQKVSFS GQPQNITTEM TGPNNTTNFM
460 470 480 490 500
TSSLPNSGSV QNNELPSSNT GAWRVSTMNH PQMQAPSGMN GTSLSHLSNG
510 520 530 540 550
ESKSGGSYGT TWGAYGSNYS GDKCSGPNGQ ANGDTVNATL MQPGVNGPMG
560 570 580 590 600
TNFQVNTNKG GGVWESGAAN SQSASWGSGN GANSGGSRRG WGTPAQNTGT
610 620 630 640 650
NLPSGEWNKL PSNQHSNDSA NGNGKKFTNG WKSTEEEDQG SATSQTNEQS
660 670 680 690 700
SVWAKTGGTV ESDGSTESTG RLEEKGTGES QSRDRRKIDQ HTLLQSIVNR
710 720 730 740 750
TDLDPRVLSN SGWGQTPIKQ NTAWDTETSP RGERKTDNGT EAWGSSATQT
760 770 780 790 800
FNSGACIDKT SPNSNDTSSV SGWGDPKPAL RWGDSKGSNC QGGWEDDSAA
810 820 830 840 850
TGMVKSNQWG NCKEEKAAWN DSQKNKQGWG DGQKSSQGWS VSASDNWGET
860 870 880 890 900
SRSNHWGEAN KKSSSGGSDS DRSVSGWNEL GKTSSFTWGN NINPNNSSGW
910 920 930 940 950
DESSKPTPSQ GWGDPPKSNQ SLGWGDSSKP VSSPDWNKQQ DIVGSWGIPP
960 970 980 990 1000
ATGKPPGTGW LGGPIPAPTK EEEPTGWEEP SPESIRRKME IDDGTSAWGD
1010 1020 1030 1040 1050
PSKYNYKNVN MWNKNVPNGN SRSDQQAQVH QLLTPASAIS NKEASSGSGW
1060 1070 1080 1090 1100
GEPWGEPSTP ATTVDNGTSA WGKPIDSGPS WGEPIAAASS TSTWGSSSVG
1110 1120 1130 1140 1150
PQALSKSGPK SMQDGWCGDD MPLPGNRPTG WEEEEDVEIG MWNSNSSQEL
1160 1170 1180 1190 1200
NSSLNWPPYT KKMSSKGLSG KKRRRERGMM KGGNKQEEAW INPFVKQFSN
1210 1220 1230 1240 1250
ISFSRDSPEE NVQSNKMDLS GGMLQDKRME IDKHSLNIGD YNRTVGKGPG
1260 1270 1280 1290 1300
SRPQISKESS MERNPYFDKD GIVADESQNM QFMSSQSMKL PPSNSALPNQ
1310 1320 1330 1340 1350
ALGSIAGLGM QNLNSVRQVS PDYNVAMRCF MFGVGNTAAQ PRGISSQPNL
1360 1370 1380 1390 1400
RAQVPPPLLS PQVPVSLLKY APNNGGLNPL FGPQQVAMLN QLSQLNQLSQ
1410 1420 1430 1440 1450
ISQLQRLLAQ QQRAQSQRSV PSGNRPQQDQ QGRPLSVQQQ MMQQSRQLDP
1460 1470 1480 1490 1500
NLLVKQQTPP SQQQPLHQPA MKSFLDNVMP HTTPELQKGP SPINAFSNFP
1510 1520 1530 1540 1550
IGLNSNLNVN MDLNSIKEPQ SRLRKWTTVD SISVNTSLDQ NSSKHGAISS
1560 1570 1580 1590 1600
GFRLEESPFV PYDFMNSSTS PASPPGSIGD GWPRAKSPNG SSSVNWPPEF
1610 1620 1630 1640 1650
RPGEPWKGYP NIDPETDPYV TPGSVINNLS INTVREVDHL RDRNSGSSSS
1660 1670 1680 1690 1700
LNTTLPSTSA WSSIRASNYN VPLSSTAQST SARNSDSKLT WSPGSVTNTS
1710 1720 1730 1740 1750
LAHELWKVPL PPKNITAPSR PPPGLTGQKP PLSTWDNSPL RVGGGWGNSD
1760 1770 1780 1790 1800
ARYTPGKMQY LRWFSVIDGS TLRTLCMQHG PLITFHLNLP HGNALVRYSS
1810 1820 1830 1840 1850
KEEVVKAQKS LHMCVLGNTT ILAEFASEEE ISRFFAQSQS LTPSPGWQSL
1860 1870 1880 1890 1900
GSSQSRLGSL DCSHSFSSRT DLNHWNGAGL SGTNCGDLHG TSLWGTPHYS
1910 1920 1930
TSLWGPPSSS DPRGISSPSP INAFLSVDHL GGGGESM
Length:1,937
Mass (Da):207,465
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8EF2C223A69C9B52
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K5K3U9A0A2K5K3U9_COLAP
Uncharacterized protein
TNRC6A
1,958Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K5K3P5A0A2K5K3P5_COLAP
Uncharacterized protein
TNRC6A
1,909Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCANT00000058971; ENSCANP00000035729; ENSCANG00000041549

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSCANT00000058971; ENSCANP00000035729; ENSCANG00000041549

Phylogenomic databases

GeneTreeiENSGT00940000158180

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR019486, Argonaute_hook_dom
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR032226, TNRC6_PABC-bd
IPR033501, TNRC6A
PANTHERiPTHR13020:SF28, PTHR13020:SF28, 1 hit
PfamiView protein in Pfam
PF10427, Ago_hook, 1 hit
PF16608, TNRC6-PABC_bdg, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K5K3N7_COLAP
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K5K3N7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: February 10, 2021
This is version 13 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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