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Protein

Protein disulfide-isomerase

Gene

PDIA4

Organism
Colobus angolensis palliatus (Peters' Angolan colobus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomeraseUniRule annotation (EC:5.3.4.1UniRule annotation)
Gene namesi
Name:PDIA4Imported
OrganismiColobus angolensis palliatus (Peters' Angolan colobus)Imported
Taxonomic identifieri336983 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeColobinaeColobus
Proteomesi
  • UP000233080 Componenti: Whole Genome Shotgun Assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24UniRule annotationAdd BLAST24
ChainiPRO_501421183625 – 646Protein disulfide-isomeraseUniRule annotationAdd BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi207 ↔ 210Redox-activeUniRule annotation
Disulfide bondi556 ↔ 559Redox-activeUniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 157ThioredoxinInterPro annotationAdd BLAST138
Domaini159 – 302ThioredoxinInterPro annotationAdd BLAST144
Domaini506 – 637ThioredoxinInterPro annotationAdd BLAST132

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili31 – 63Sequence analysisAdd BLAST33

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Redox-active centerUniRule annotationSAAS annotation, RepeatSAAS annotation, SignalUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00860000133691

Family and domain databases

InterProiView protein in InterPro
IPR005788 Disulphide_isomerase
IPR005792 Prot_disulphide_isomerase
IPR017068 Protein_diS-isomerase_A4
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 3 hits
PIRSFiPIRSF036862 Disulphide_isom_A4, 1 hit
SUPFAMiSSF52833 SSF52833, 5 hits
TIGRFAMsiTIGR01130 ER_PDI_fam, 1 hit
TIGR01126 pdi_dom, 3 hits
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 3 hits
PS51352 THIOREDOXIN_2, 3 hits

Sequencei

Sequence statusi: Complete.

A0A2K5J4I9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPRKAYLFL LLLGLAQLLA VAGAEGPDED SSNRENAIED EEEEEEEEED
60 70 80 90 100
DEEEDDLEVK EENGVLVLND ANFDNFVADK DTVLLEFYAP WCGHCKQFAP
110 120 130 140 150
EYEKIANVLK DNDPPIPVAK IDATSASMLA SRFDVSGYPT IKILKKGQAV
160 170 180 190 200
DYEGSRTQEE IVAKVREVSQ PDWTPPPEVT LVLTKENFDE VVNDADIILV
210 220 230 240 250
EFYAPWCGHC KKLAPEYEKA AKELNKRSPP IPLAKVDAIA ETDLAKRFDV
260 270 280 290 300
SGYPTLKIFR KGRPFDYNGP REKYGIVDYM IEQSGPPSKE ILTLKQVQEF
310 320 330 340 350
LKDGDDVIII GVFEGESDPA YQQYQDAANN LREDYKFHHA FSTEIAKFLK
360 370 380 390 400
VSQGQLVVMQ PEKFQSKYEP RSHVMDVQGS TQDSAIKDFV LKYALPLVGH
410 420 430 440 450
RKASNEAKRY TRRPLVVVYY SVDFSFDYRA ATQFWRSKVL EVAKDFPEYT
460 470 480 490 500
FAIADEEDYA GEVKDLGLSE SGEDVNAAIL DESGKKFAME PEEFDSDTLR
510 520 530 540 550
EFVTAFKKGK LKPVIKSQPV PKNNKGPVKV VVGKTFDSIV MDPKKDVLIE
560 570 580 590 600
FYAPWCGHCK QLEPVYSSLA KKYKGQKGLV IAKMDATAND VPSDRYKVEG
610 620 630 640
FPTIYFAPSG DKKNPVKFEG GDRDLEHLSK FIEEHATKLS RTKEEL
Length:646
Mass (Da):73,022
Last modified:March 28, 2018 - v1
Checksum:i593800EF5ED4E230
GO

Sequence databases

RefSeqiXP_011796809.1, XM_011941419.1

Genome annotation databases

EnsembliENSCANT00000046822; ENSCANP00000023829; ENSCANG00000035323
GeneIDi105511284

Similar proteinsi

Entry informationi

Entry nameiA0A2K5J4I9_COLAP
AccessioniPrimary (citable) accession number: A0A2K5J4I9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: July 18, 2018
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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