Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA primase large subunit

Gene

PRIM2

Organism
Colobus angolensis palliatus (Peters' Angolan colobus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi287Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi367Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi384Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi424Iron-sulfur (4Fe-4S)UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionDNA-bindingUniRule annotation, NucleotidyltransferaseUniRule annotation, Transferase
Biological processDNA replicationUniRule annotation, Transcription
Ligand4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA primase large subunitUniRule annotation (EC:2.7.7.-UniRule annotation)
Gene namesi
Name:PRIM2Imported
OrganismiColobus angolensis palliatus (Peters' Angolan colobus)Imported
Taxonomic identifieri336983 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeColobinaeColobus
Proteomesi
  • UP000233080 Componenti: Whole Genome Shotgun Assembly

Subcellular locationi

    Keywords - Cellular componenti

    DNA-directed RNA polymeraseUniRule annotation, PrimosomeUniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eukaryotic-type primase large subunit family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000009790

    Family and domain databases

    CDDicd07322 PriL_PriS_Eukaryotic, 1 hit
    InterProiView protein in InterPro
    IPR016558 DNA_primase_lsu_euk
    IPR007238 DNA_primase_lsu_euk/arc
    PANTHERiPTHR10537 PTHR10537, 1 hit
    PfamiView protein in Pfam
    PF04104 DNA_primase_lrg, 1 hit
    PIRSFiPIRSF009449 DNA_primase_large_subunit, 1 hit

    Sequencei

    Sequence statusi: Complete.

    A0A2K5I886-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MEFSKRKWRM LRLAGDQRNA SYPHCLQFYL QPPSENISLI EFENLAIDRV
    60 70 80 90 100
    KLLKSVENLG VSYVKGTEQY QSKLESELRR LKFSYRENLE DEYEPRRRDH
    110 120 130 140 150
    ISHFILRLAY CQSEELRRWF IQQEMDLLRF RFSILPKDKI QDFLKDSQLQ
    160 170 180 190 200
    FEAISDEEKT LRELEIIASS PNLSGSKLVL ESIYKIPFAD ALDLFRGRKV
    210 220 230 240 250
    YLEDGFAYVP LKDIVAIILN EFRAKLSKAL ALTARSLPAV QSDERLQPLL
    260 270 280 290 300
    NHLSHSYTGQ DYSTQGNVGK ISLDQIDLLS IKSFPPCMRQ LHKALRENHH
    310 320 330 340 350
    LRHGGRMQYG LFLKGIGLTL EQALQFWKQE FIKGKMDPDK FDKGYSYNIR
    360 370 380 390 400
    HSFGKEGKRT DYTPFSCLKI ILSNPPSQGD YHGCPFRHSD PELLKQKLQS
    410 420 430 440 450
    YKISPGGISQ ILDLAKGTHY QVACQKYFEM IHNVDDCGFS LNHPNQFFCE
    460 470 480 490 500
    SQRILNGGKD IKKEPIQPET PQPKPSIQKT KDVSSALASL NSSLEMDMEG

    LEDYFSEDS
    Length:509
    Mass (Da):58,942
    Last modified:March 28, 2018 - v1
    Checksum:iB7640E8AA69755C5
    GO

    Sequence databases

    RefSeqiXP_011801010.1, XM_011945620.1
    XP_011801011.1, XM_011945621.1

    Genome annotation databases

    EnsembliENSCANT00000035760; ENSCANP00000012848; ENSCANG00000029823
    GeneIDi105514323

    Similar proteinsi

    Cross-referencesi

    Sequence databases

    RefSeqiXP_011801010.1, XM_011945620.1
    XP_011801011.1, XM_011945621.1

    3D structure databases

    ModBaseiSearch...
    MobiDBiSearch...

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENSCANT00000035760; ENSCANP00000012848; ENSCANG00000029823
    GeneIDi105514323

    Organism-specific databases

    CTDi5558

    Phylogenomic databases

    GeneTreeiENSGT00390000009790

    Family and domain databases

    CDDicd07322 PriL_PriS_Eukaryotic, 1 hit
    InterProiView protein in InterPro
    IPR016558 DNA_primase_lsu_euk
    IPR007238 DNA_primase_lsu_euk/arc
    PANTHERiPTHR10537 PTHR10537, 1 hit
    PfamiView protein in Pfam
    PF04104 DNA_primase_lrg, 1 hit
    PIRSFiPIRSF009449 DNA_primase_large_subunit, 1 hit
    ProtoNetiSearch...

    Entry informationi

    Entry nameiA0A2K5I886_COLAP
    AccessioniPrimary (citable) accession number: A0A2K5I886
    Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
    Last sequence update: March 28, 2018
    Last modified: July 18, 2018
    This is version 4 of the entry and version 1 of the sequence. See complete history.
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again