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Entry version 16 (02 Jun 2021)
Sequence version 1 (28 Mar 2018)
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Protein
Submitted name:

Treacle ribosome biogenesis factor 1

Gene
N/A
Organism
Colobus angolensis palliatus (Peters' Angolan colobus)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Treacle ribosome biogenesis factor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiColobus angolensis palliatus (Peters' Angolan colobus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri336983 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeColobinaeColobus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000233080 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 38LisHInterPro annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni57 – 1207DisorderedSequence analysisAdd BLAST1151
Regioni1242 – 1406DisorderedSequence analysisAdd BLAST165

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi57 – 74Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi101 – 116Polar residuesSequence analysisAdd BLAST16
Compositional biasi140 – 174Polar residuesSequence analysisAdd BLAST35
Compositional biasi256 – 275Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi347 – 364Polar residuesSequence analysisAdd BLAST18
Compositional biasi562 – 576Polar residuesSequence analysisAdd BLAST15
Compositional biasi692 – 708Polar residuesSequence analysisAdd BLAST17
Compositional biasi785 – 799Acidic residuesSequence analysisAdd BLAST15
Compositional biasi840 – 865Polar residuesSequence analysisAdd BLAST26
Compositional biasi894 – 914Polar residuesSequence analysisAdd BLAST21
Compositional biasi1006 – 1039Polar residuesSequence analysisAdd BLAST34
Compositional biasi1087 – 1103Polar residuesSequence analysisAdd BLAST17
Compositional biasi1112 – 1157Polar residuesSequence analysisAdd BLAST46
Compositional biasi1242 – 1272Basic and acidic residuesSequence analysisAdd BLAST31
Compositional biasi1304 – 1345Basic and acidic residuesSequence analysisAdd BLAST42
Compositional biasi1360 – 1376Basic residuesSequence analysisAdd BLAST17
Compositional biasi1377 – 1391Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1392 – 1406Basic residuesSequence analysisAdd BLAST15

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
614008at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006594, LisH
IPR017859, Treacle
IPR003993, Treacle_dom

The PANTHER Classification System

More...
PANTHERi
PTHR20787, PTHR20787, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03546, Treacle, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00667, LisH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50896, LISH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A2K5HDZ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEARKRREL LPLIYHHLLR AGYVRAAREV KEQSGQKCFL AQPVTLLDIY
60 70 80 90 100
THWQQTSELG RKRKAEEDAA LQAKKTRVSD PISTSESSEE EEEAEAETTK
110 120 130 140 150
ATPRLASTNS SVLGADLPSS LKEKAKAETE KAGKTGNSMP HPATGKTVTN
160 170 180 190 200
LLSGKSPRKS GEPSANTTLV SETEEEGSVP AFGAAAKPGM VSAGQADSSS
210 220 230 240 250
EDTSSSSDET DVEVKASEKI LQVKAALTPA KGTPGKGATP APPGKAGAVA
260 270 280 290 300
FQTKAGKPEE DSESSSKESS DSEEKTPPAK ALLQAKASGK TPQVGAASAP
310 320 330 340 350
AKESPRKGAA PAPPGKTGPT VAKAQTGKQE EDSQSSSEES DSEEEAPAQT
360 370 380 390 400
KPSGKTSQVR AASASAKESP RKGAAPAPPR KTGPAATQAQ AGKQEEDSGS
410 420 430 440 450
SSEESDSDRE APAAMNAAQV KPLGKNPQVK PASTMGMGPL GKGAGPVLPG
460 470 480 490 500
KVGPTTPSAQ VGKWEDSDSS SEESSDSDDG EVPTAVAPAQ EKSLGKVLQA
510 520 530 540 550
KPASGPAKGP PQKAGPVAIQ VKAEKPTEDS ESSEESSDSE EAPAAVTAAQ
560 570 580 590 600
AKPALKIPQT KACPKKTNTA SAKVTPVRVG TQAPRKAGTA PPPVGSSPAV
610 620 630 640 650
AGGTQRPAED SSSSEESDSE EEKTGPAVTM GQAKSVGKGL RVKAASVPVK
660 670 680 690 700
GSLGQGTAPV LPGKTGPTVT QVKAEMQEDS ESSEEESDSE EAAATSAQVK
710 720 730 740 750
TSVKKTQAKA NPAAVRASPA KGTISAPGKV VTAAAQAKQR SPAKAKPPVR
760 770 780 790 800
NLQNSTVLVK GPASVPPVGK AVAAAAQAQT GPEEDSGSSE EESDSEEETE
810 820 830 840 850
MPAQANPSGK TPQVRATLAP AKESPRKGTA PAPPGKTGPS ATQAGKQDDS
860 870 880 890 900
GSSSEESNSD GEAPAAATSA QVIKPPLIFV DPNRSPAGPA ATPVQAQAAS
910 920 930 940 950
TPRKSRASES TARSSSSESE DEDVIPATQC LTPGIRTNVV TVPTAHPRIA
960 970 980 990 1000
PKASMTGASN SKESSRISDG KKQERPATQV SKKNSASLPL TQAALKVLAQ
1010 1020 1030 1040 1050
KASEAQPPVA RTQPSSGADS AVGTLPATSP QSTPVQAKGT NKLRKPKLPE
1060 1070 1080 1090 1100
GQQATKAPGS SDDSEDSNDS SSGSEEDAEG PQVAKSARTL VGSTPSRTET
1110 1120 1130 1140 1150
LVEETAAESS EDDVVAPSQS LLSGYVTTGL TPANSQASKA TPKPYSSPSV
1160 1170 1180 1190 1200
SSTLATKDDP DGKQEAKPQQ AAGMLSPKTG GKEAASGTAP QKSRKPKKGA
1210 1220 1230 1240 1250
GNPQASTLAL QSNITQCLLG QPWPLNEAQV QASVVKVLTE LLEQERKKVV
1260 1270 1280 1290 1300
DATKESSRKG WESRKRKLSG DQPAARTPRS KKKKKLGAGE GGEASVSPEK
1310 1320 1330 1340 1350
TSTTSKGKAK RDKASDDVKE KKGKGSLGSQ GAKDEPEKEL QKGMGKVEGG
1360 1370 1380 1390 1400
DQSNPKSKKE KKKSDKRKKD KEKKEKKKAK KSSTKDSESP SQKKKKKKKK

TAEQTV
Length:1,406
Mass (Da):144,123
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAE1EB60D607B5997
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K5HDZ0A0A2K5HDZ0_COLAP
Treacle ribosome biogenesis factor ...
1,482Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K5HE06A0A2K5HE06_COLAP
Treacle ribosome biogenesis factor ...
1,445Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K5HE15A0A2K5HE15_COLAP
Treacle ribosome biogenesis factor ...
956Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K5HE51A0A2K5HE51_COLAP
Treacle ribosome biogenesis factor ...
1,482Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_011786956.1, XM_011931566.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCANT00000010526; ENSCANP00000002573; ENSCANG00000009157

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
105504232

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_011786956.1, XM_011931566.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSCANT00000010526; ENSCANP00000002573; ENSCANG00000009157
GeneIDi105504232

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6949

Phylogenomic databases

OrthoDBi614008at2759

Family and domain databases

InterProiView protein in InterPro
IPR006594, LisH
IPR017859, Treacle
IPR003993, Treacle_dom
PANTHERiPTHR20787, PTHR20787, 3 hits
PfamiView protein in Pfam
PF03546, Treacle, 3 hits
SMARTiView protein in SMART
SM00667, LisH, 1 hit
PROSITEiView protein in PROSITE
PS50896, LISH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K5HDZ4_COLAP
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K5HDZ4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: June 2, 2021
This is version 16 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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