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Entry version 16 (02 Jun 2021)
Sequence version 1 (28 Mar 2018)
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Protein
Submitted name:

Treacle ribosome biogenesis factor 1

Gene
N/A
Organism
Colobus angolensis palliatus (Peters' Angolan colobus)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Treacle ribosome biogenesis factor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiColobus angolensis palliatus (Peters' Angolan colobus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri336983 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeColobinaeColobus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000233080 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 38LisHInterPro annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni57 – 1283DisorderedSequence analysisAdd BLAST1227
Regioni1318 – 1482DisorderedSequence analysisAdd BLAST165

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi57 – 74Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi101 – 116Polar residuesSequence analysisAdd BLAST16
Compositional biasi140 – 174Polar residuesSequence analysisAdd BLAST35
Compositional biasi333 – 352Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi424 – 441Polar residuesSequence analysisAdd BLAST18
Compositional biasi639 – 653Polar residuesSequence analysisAdd BLAST15
Compositional biasi769 – 785Polar residuesSequence analysisAdd BLAST17
Compositional biasi862 – 876Acidic residuesSequence analysisAdd BLAST15
Compositional biasi917 – 942Polar residuesSequence analysisAdd BLAST26
Compositional biasi971 – 991Polar residuesSequence analysisAdd BLAST21
Compositional biasi1083 – 1116Polar residuesSequence analysisAdd BLAST34
Compositional biasi1163 – 1179Polar residuesSequence analysisAdd BLAST17
Compositional biasi1188 – 1233Polar residuesSequence analysisAdd BLAST46
Compositional biasi1318 – 1348Basic and acidic residuesSequence analysisAdd BLAST31
Compositional biasi1380 – 1421Basic and acidic residuesSequence analysisAdd BLAST42
Compositional biasi1436 – 1452Basic residuesSequence analysisAdd BLAST17
Compositional biasi1453 – 1467Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1468 – 1482Basic residuesSequence analysisAdd BLAST15

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
614008at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006594, LisH
IPR017859, Treacle
IPR003993, Treacle_dom

The PANTHER Classification System

More...
PANTHERi
PTHR20787, PTHR20787, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03546, Treacle, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00667, LisH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50896, LISH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A2K5HDZ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEARKRREL LPLIYHHLLR AGYVRAAREV KEQSGQKCFL AQPVTLLDIY
60 70 80 90 100
THWQQTSELG RKRKAEEDAA LQAKKTRVSD PISTSESSEE EEEAEAETTK
110 120 130 140 150
ATPRLASTNS SVLGADLPSS LKEKAKAETE KAGKTGNSMP HPATGKTVTN
160 170 180 190 200
LLSGKSPRKS GEPSANTTLV SETEEEGSVP AFGAAAKPGM VSAGQADSSS
210 220 230 240 250
EDTSSSSDET DVEGKPSVKP AQVKASSVST KESPARKAAP APGKVGDVTP
260 270 280 290 300
QVRGGALPPA KRAKKPEEES ESSEEGSESE EEAPAGTPSQ VKASEKILQV
310 320 330 340 350
KAALTPAKGT PGKGATPAPP GKAGAVAFQT KAGKPEEDSE SSSKESSDSE
360 370 380 390 400
EKTPPAKALL QAKASGKTPQ VGAASAPAKE SPRKGAAPAP PGKTGPTVAK
410 420 430 440 450
AQTGKQEEDS QSSSEESDSE EEAPAQTKPS GKTSQVRAAS ASAKESPRKG
460 470 480 490 500
AAPAPPRKTG PAATQAQAGK QEEDSGSSSE ESDSDREAPA AMNAAQVKPL
510 520 530 540 550
GKNPQVKPAS TMGMGPLGKG AGPVLPGKVG PTTPSAQVGK WEDSDSSSEE
560 570 580 590 600
SSDSDDGEVP TAVAPAQEKS LGKVLQAKPA SGPAKGPPQK AGPVAIQVKA
610 620 630 640 650
EKPTEDSESS EESSDSEEAP AAVTAAQAKP ALKIPQTKAC PKKTNTASAK
660 670 680 690 700
VTPVRVGTQA PRKAGTAPPP VGSSPAVAGG TQRPAEDSSS SEESDSEEEK
710 720 730 740 750
TGPAVTMGQA KSVGKGLRVK AASVPVKGSL GQGTAPVLPG KTGPTVTQVK
760 770 780 790 800
AEMQEDSESS EEESDSEEAA ATSAQVKTSV KKTQAKANPA AVRASPAKGT
810 820 830 840 850
ISAPGKVVTA AAQAKQRSPA KAKPPVRNLQ NSTVLVKGPA SVPPVGKAVA
860 870 880 890 900
AAAQAQTGPE EDSGSSEEES DSEEETEMPA QANPSGKTPQ VRATLAPAKE
910 920 930 940 950
SPRKGTAPAP PGKTGPSATQ AGKQDDSGSS SEESNSDGEA PAAATSAQVI
960 970 980 990 1000
KPPLIFVDPN RSPAGPAATP VQAQAASTPR KSRASESTAR SSSSESEDED
1010 1020 1030 1040 1050
VIPATQCLTP GIRTNVVTVP TAHPRIAPKA SMTGASNSKE SSRISDGKKQ
1060 1070 1080 1090 1100
ERPATQVSKK NSASLPLTQA ALKVLAQKAS EAQPPVARTQ PSSGADSAVG
1110 1120 1130 1140 1150
TLPATSPQST PVQAKGTNKL RKPKLPEGQQ ATKAPGSSDD SEDSNDSSSG
1160 1170 1180 1190 1200
SEEDAEGPQV AKSARTLGST PSRTETLVEE TAAESSEDDV VAPSQSLLSG
1210 1220 1230 1240 1250
YVTTGLTPAN SQASKATPKP YSSPSVSSTL ATKDDPDGKQ EAKPQQAAGM
1260 1270 1280 1290 1300
LSPKTGGKEA ASGTAPQKSR KPKKGAGNPQ ASTLALQSNI TQCLLGQPWP
1310 1320 1330 1340 1350
LNEAQVQASV VKVLTELLEQ ERKKVVDATK ESSRKGWESR KRKLSGDQPA
1360 1370 1380 1390 1400
ARTPRSKKKK KLGAGEGGEA SVSPEKTSTT SKGKAKRDKA SDDVKEKKGK
1410 1420 1430 1440 1450
GSLGSQGAKD EPEKELQKGM GKVEGGDQSN PKSKKEKKKS DKRKKDKEKK
1460 1470 1480
EKKKAKKSST KDSESPSQKK KKKKKKTAEQ TV
Length:1,482
Mass (Da):151,785
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i150BA5BD1DFC1029
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K5HDZ4A0A2K5HDZ4_COLAP
Treacle ribosome biogenesis factor ...
1,406Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K5HE06A0A2K5HE06_COLAP
Treacle ribosome biogenesis factor ...
1,445Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K5HE15A0A2K5HE15_COLAP
Treacle ribosome biogenesis factor ...
956Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K5HE51A0A2K5HE51_COLAP
Treacle ribosome biogenesis factor ...
1,482Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_011786953.1, XM_011931563.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCANT00000010431; ENSCANP00000002555; ENSCANG00000009157

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
105504232

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_011786953.1, XM_011931563.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSCANT00000010431; ENSCANP00000002555; ENSCANG00000009157
GeneIDi105504232

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6949

Phylogenomic databases

OrthoDBi614008at2759

Family and domain databases

InterProiView protein in InterPro
IPR006594, LisH
IPR017859, Treacle
IPR003993, Treacle_dom
PANTHERiPTHR20787, PTHR20787, 2 hits
PfamiView protein in Pfam
PF03546, Treacle, 4 hits
SMARTiView protein in SMART
SM00667, LisH, 1 hit
PROSITEiView protein in PROSITE
PS50896, LISH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K5HDZ0_COLAP
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K5HDZ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: June 2, 2021
This is version 16 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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